|
rs121918464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Wild type SHP-2 and four disease-associated mutants recurring in hematologic malignancies (Glu76Lys and Ala72Val) or causing NS (Glu76Asp and Ala72Ser), with affected residues located in the PTP-interacting region of the N-SH2 domain, were analyzed by molecular dynamics simulations and in vitro biochemical assays.
|
17177198 |
2007 |
|
rs1239105602
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Wild type SHP-2 and four disease-associated mutants recurring in hematologic malignancies (Glu76Lys and Ala72Val) or causing NS (Glu76Asp and Ala72Ser), with affected residues located in the PTP-interacting region of the N-SH2 domain, were analyzed by molecular dynamics simulations and in vitro biochemical assays.
|
17177198 |
2007 |
|
rs13347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our results indicate that among investigated single nucleotide polymorphisms (SNPs), only CD44 rs13347 has an impact on the efficacy of HSCs mobilization in patients with hematologic malignancies.
|
24680978 |
2014 |
|
rs148704956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLA-matched myeloablative (discovery study) and nonmyeloablative (validation study) BMT through the Japan Marrow Donor Program (JMDP).
|
21217785 |
2011 |
|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current meta-analysis indicated that the Arg194Trp polymorphism in the XRCC1 gene might be not a risk factor for hematological malignancies.
|
24414482 |
2014 |
|
rs1800023
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We retrospectively examined the impact of the CCR5 variation (rs1800023, -2086A>G) on transplant outcomes in a cohort of 329 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program.
|
28487238 |
2017 |
|
rs1801157
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several recent studies have shown that <i>SDF1</i>-3'A polymorphism (rs1801157) is associated with susceptibility to hematological malignancy, but published studies' results are disputed.
|
28352190 |
2017 |
|
rs1801271
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
FMS mutations in myelodysplastic, leukemic, and normal subjects.
|
2406720 |
1990 |
|
rs1801271
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
FMS mutations in myelodysplastic, leukemic, and normal subjects.
|
2406720 |
1990 |
|
rs2229094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup meta-analysis suggested that rs2239704 was likely to increase the risk of hematological malignancy (OR = 1.10, 99% CI = 1.01-1.20, P = 0.023, I(2) = 0.0%), and rs2229094 was specific for the increased risk of adenocarcinoma (OR = 1.33, 99% CI = 1.11-1.59, P = 0.002, I(2) = 0.0%).
|
24349304 |
2013 |
|
rs2239704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup meta-analysis suggested that rs2239704 was likely to increase the risk of hematological malignancy (OR = 1.10, 99% CI = 1.01-1.20, P = 0.023, I(2) = 0.0%), and rs2229094 was specific for the increased risk of adenocarcinoma (OR = 1.33, 99% CI = 1.11-1.59, P = 0.002, I(2) = 0.0%).
|
24349304 |
2013 |
|
rs2285489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We retrospectively examined whether <i>ADAMTS13</i> rs2285489 affected the transplant outcomes in a cohort of 281 patients who underwent unrelated human leukocyte antigen (HLA)-matched bone marrow transplantation for hematologic malignancies.
|
30626079 |
2019 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current meta-analysis indicated that the Arg399Gln polymorphism in the XRCC1 gene might be a risk factor for hematological malignancies in Asians or for leukemia.
|
25619474 |
2015 |
|
rs25489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current meta-analysis indicated that the Arg280His polymorphism in the XRCC1 gene might not be a risk factor for hematological malignancies.
|
24096581 |
2014 |
|
rs267606706
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.
|
23696637 |
2013 |
|
rs3745274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrates for the first time that the presence of the CYP2B6 G516T mutation increases the rate of 4-OH-CPA formation in patients with hematological malignancies.
|
16183265 |
2006 |
|
rs387906664
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN.
|
23696637 |
2013 |
|
rs387907272
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, the seminal discoveries of MYD88 (L265P) mutation, present in the vast majority (85-100 %), and CXCR4 (WHIM) mutations, identified in nearly a third of patients (who almost exclusively harbor the MYD88 (L265P) variant), have laid a solid foundation for a paradigm shift in our diagnostic and therapeutic approaches towards this rare hematologic malignancy.
|
26942591 |
2016 |
|
rs387907272
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although the absence of the MyD88 L265P somatic mutation in our SS cohort does not exclude a common germline susceptibility gene in SS, it might suggest a distinct operating pathogenetic mechanism in SS-related lymphoma compared with WM and other hematological malignancies.
|
24153350 |
2014 |
|
rs3921
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study retrospectively examined the impact of a single nucleotide variation (rs3921, +1642C>G) in the CXCL10 gene on transplant outcomes in a cohort of 652 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies.
|
23291247 |
2013 |
|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis.
|
31188929 |
2019 |
|
rs397507514
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Wild type SHP-2 and four disease-associated mutants recurring in hematologic malignancies (Glu76Lys and Ala72Val) or causing NS (Glu76Asp and Ala72Ser), with affected residues located in the PTP-interacting region of the N-SH2 domain, were analyzed by molecular dynamics simulations and in vitro biochemical assays.
|
17177198 |
2007 |
|
rs562015640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Wild type SHP-2 and four disease-associated mutants recurring in hematologic malignancies (Glu76Lys and Ala72Val) or causing NS (Glu76Asp and Ala72Ser), with affected residues located in the PTP-interacting region of the N-SH2 domain, were analyzed by molecular dynamics simulations and in vitro biochemical assays.
|
17177198 |
2007 |
|
rs5743551
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We retrospectively examined whether or not genetic variations in toll-like receptor 1 (rs5743551, -7202GQ>A), toll-like receptor 2 (rs7656411, 22215G>T), and toll-like receptor 4 (rs11536889, +3725G>C) affected transplant outcomes in a cohort of 365 patients who underwent unrelated HLA-matched bone marrow transplantation (for hematologic malignancies through the Japan Marrow Donor Program.
|
28484092 |
2017 |
|
rs61754966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We screened healthy controls and pediatric patients with hematological malignancies and aplastic anemia (AA) for the presence of I171V.
|
15338273 |
2004 |