|
rs121918504
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1554196416
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1554700718
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1554888939
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs879253753
|
|
CT |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs2162540
|
|
|
0.010 |
GeneticVariation |
BEFREE |
That is, rs2162540 was significantly associated with skeletal class II malocclusion, while others were associated with skeletal class III malocclusion.
|
31509720 |
2019 |
|
rs551639398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We cross-checked our exome data of 215 people for rare variants in ADAMTSL1 and found that the c.670C>G variant was associated with mandibular prognathism in families 2 and 4.
|
30714143 |
2019 |
|
rs3825393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A nonsynonymous common variant of MYO1H rs3825393, C>T, p.Pro1001Leu, was identified to be significantly associated with MP.
|
29986156 |
2018 |
|
rs13317
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified 3 variants: rs13317 in FGFR1, rs149242678 in FGF20, and rs79176051 FGF12 associated with MP (P < .05).
|
28640125 |
2017 |
|
rs149242678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified 3 variants: rs13317 in FGFR1, rs149242678 in FGF20, and rs79176051 FGF12 associated with MP (P < .05).
|
28640125 |
2017 |
|
rs372127537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations of common and rare variants with MP as a categorical phenotype and also continuous malocclusion phenotypes generated by principal component (PC) analysis were analyzed.One common variant, rs372127537, located in the 3'-untranslated region of FGF7 gene, was significantly related to PC1 (P = 4.22 × 10), which explained 23.23% of the overall phenotypic variation observed and corresponded to vertical discrepancies ranging from short anterior face height to long anterior face height, after Bonferroni correction.
|
28640125 |
2017 |
|
rs79176051
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified 3 variants: rs13317 in FGFR1, rs149242678 in FGF20, and rs79176051 FGF12 associated with MP (P < .05).
|
28640125 |
2017 |
|
rs111419738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the Gly1121Ser variant in the ARHGAP21 gene was found to be shared by all MP individuals in the larger branch of the family with nearly complete penetrance.
|
25691070 |
2015 |
|
rs229038
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Final results suggested that 2 single-nucleotide polymorphisms (rs2738, rs229038) of ADAMTS1 were significantly associated with mandibular prognathism.
|
26124221 |
2015 |
|
rs2738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Final results suggested that 2 single-nucleotide polymorphisms (rs2738, rs229038) of ADAMTS1 were significantly associated with mandibular prognathism.
|
26124221 |
2015 |
|
rs1793953
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the analysis of individual SNPs, the SNP rs1793953 in the COL2A1 gene showed a possible association with MP with regard to allelic frequency and genotypic distribution (p = 0.031; p = 0.025, respectively) in the 211 cases and 224 controls.
|
24386886 |
2014 |
|
rs6182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Relationship between P561T and C422F polymorphisms in growth hormone receptor gene and mandibular prognathism.
|
24654940 |
2014 |
|
rs6184
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Relationship between P561T and C422F polymorphisms in growth hormone receptor gene and mandibular prognathism.
|
24654940 |
2014 |
|
rs4654388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the analysis of single SNPs in the second stage, the allele of rs4654388 showed the strongest significant association with MP (P=0.008) and the rs4654388 G-allele was associated with a significantly increased risk of MP (OR: 1.78, 95% CI: 1.16-2.74).
|
20797695 |
2010 |