|
rs17618244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we showed an association between the rs17618244 KLB variant, which leads to reduced KLB expression, and the severity of NAFLD in pediatric patients.
|
31655133 |
2020 |
|
rs537635771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to elucidate whether PNPLA3 I148M is involved in NF-kB-related inflammation regulation in NAFLD.
|
31793207 |
2020 |
|
rs768007422
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to elucidate whether PNPLA3 I148M is involved in NF-kB-related inflammation regulation in NAFLD.
|
31793207 |
2020 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease.
|
29733805 |
2019 |
|
rs1044498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three of the 14 SNPs were significantly associated with paediatric NAFLD after FDR adjustment, rs738409 (PNPLA3, P = 2.80 × 10<sup>-06</sup> ), rs1044498 (ENPP1, P = 0.0091) and rs780094 (GCKR, P = 0.0281).
|
30444569 |
2019 |
|
rs10883437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we accessed the seven polymorphisms of rs1260326, rs780094 in GCKR, rs2954021 near TRIB1, rs2228603 in NCAN, rs58542926 in TM6SF2, rs12137855 near LYPLAL1, and rs10883437 near CPN1 on NAFLD susceptibility in the Uygur population.
|
30646922 |
2019 |
|
rs12152703
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>KLB</i> rs7674434 and rs12152703 had associations with alanine aminotransferase (ALT) (<i>P</i> = 0.03 and <i>P</i> = 0.04, respectively) and gamma-glutamyltransferase (<i>P</i> = 0.03 and <i>P</i> = 0.02, respectively) levels in all subjects, but the associations were especially strong with ALT in the NAFLD group (<i>P</i> = 0.005 and <i>P</i> = 0.008, respectively).
|
31548436 |
2019 |
|
rs1292932521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease.
|
29733805 |
2019 |
|
rs1492100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, among the 10 SNPs negatively associated with NAFLD, the four-locus model (rs13431696 and rs3856806 in PPARγ, and rs5182, rs1492100 in ATGR1) and the five-locus model (rs9817428, rs1175543, rs13433696, and rs2920502 in PPARγ, and rs1492100 in ATGR1) were closely related with NAFLD susceptibility (p = 0.019 and p = 0.048, respectively).
|
30793973 |
2019 |
|
rs1799864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease.
|
29733805 |
2019 |
|
rs1799864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease.
|
29733805 |
2019 |
|
rs2236212
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the eleven genotyped SNPs, the genetic variants in TM6SF2 rs58542926 (OR = 4.13, p = 0.002), GCKR rs1260326 (OR = 1.53, p = 0.003), PNPLA3 rs738409 (OR = 1.58, p = 0.004) and ELOVL2 rs2236212 (OR = 1.34, p = 0.047) were significantly associated with a higher risk of NAFLD.
|
31255630 |
2019 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings of this study suggest that there may be an association between IL-17A (-197 G/A) (rs2275913) polymorphism and non-alcoholic fatty liver disease development in obese Turkish children.
|
29733805 |
2019 |
|
rs2281135
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNP-diagnosis pairs passed the phenome-wide significance threshold: rs9273349 and E06 (thyroiditis, p = 5.50x10-8); rs9273349 and E10 (type-1 diabetes, p = 2.60x10-7); and rs2281135 and K76 (non-alcoholic liver diseases, including NAFLD, p = 4.10x10-7).
|
30978214 |
2019 |
|
rs2303861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When Bonferroni correction was applied, NAFLD was significantly associated with rs2303861, a variant located in the CD82 gene (P=2.49×10-7, adjusted P=0.0059).
|
31483122 |
2019 |
|
rs236918
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to examine the impact of the <i>PCSK7</i> rs236918 variant on NAFLD-related traits in 1,801 individuals from the Liver Biopsy Cohort (LBC), 500,000 from the UK Biobank Cohort (UKBBC), and 4,580 from the Dallas Heart Study (DHS).
|
30918065 |
2019 |
|
rs2638360
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting the covariance, the results from the overdominant model showed that participants carrying the T/C genotype of rs2638360 in AGTR1 have a decreased risk of NAFLD compared with those with T/T-C/C genotypes (odds ratio: 0.70, 95% confidence interval: 0.49-1.00).
|
30793973 |
2019 |
|
rs2920502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, among the 10 SNPs negatively associated with NAFLD, the four-locus model (rs13431696 and rs3856806 in PPARγ, and rs5182, rs1492100 in ATGR1) and the five-locus model (rs9817428, rs1175543, rs13433696, and rs2920502 in PPARγ, and rs1492100 in ATGR1) were closely related with NAFLD susceptibility (p = 0.019 and p = 0.048, respectively).
|
30793973 |
2019 |
|
rs2954029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TRIB1 rs17321515 and rs2954029 were significant associated with the risk of NAFLD in Chinese Han population.
|
30851741 |
2019 |
|
rs3834458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Serum FADS2 concentration was positively correlated with the susceptibility of NAFLD with CAD, while the polymorphism of rs3834458 was not associated with NAFLD with CAD.
|
31781193 |
2019 |
|
rs4149313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease.
|
29733805 |
2019 |
|
rs5182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, among the 10 SNPs negatively associated with NAFLD, the four-locus model (rs13431696 and rs3856806 in PPARγ, and rs5182, rs1492100 in ATGR1) and the five-locus model (rs9817428, rs1175543, rs13433696, and rs2920502 in PPARγ, and rs1492100 in ATGR1) were closely related with NAFLD susceptibility (p = 0.019 and p = 0.048, respectively).
|
30793973 |
2019 |
|
rs5186
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Angiotensin II Type 1 Receptor rs5186 Gene Variant Predicts Incident NAFLD and Associated Hypertension: Role of Dietary Fat-Induced Pro-Inflammatory Cell Activation.
|
30920415 |
2019 |
|
rs5748926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified novel loci for NAFLD disease severity, including one novel locus for NAS score near IL17RA (rs5748926, p = 3.80 × 10<sup>- 8</sup>), and another near ZFP90-CDH1 for fibrosis (rs698718, p = 2.74 × 10<sup>- 11</sup>).
|
31311600 |
2019 |
|
rs5854292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share risk factors, and recent meta-analysis confirmed that NAFLD is an independent risk factor for incident CKD.<sup>1</sup> Genetic variants associated with NAFLD, such as patatin-like phospholipase domain-containing-3 (PNPLA3) rs738409<sup>2</sup> and transmembrane 6 superfamily member 2 (TM6SF2) rs5854292,<sup>2</sup> have been reported to be associated with renal function in NAFLD subjects.
|
31546054 |
2019 |