|
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyperactivity-impulsivity score revealed association with rs5742905 'TT' and rs2236225 'CC', while rs1801133 'CC' showed association with inattentiveness and hyperactivity-impulsivity. rs1801131 exhibited strong synergistic interaction with rs1051266 and rs2236225.
|
28250422 |
2017 |
|
rs1170695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, rs1170695 has been found to be associated with the ADHD risk in the addictive model (OR=1.457, 95%CI=1.173-1.809), while rs9990174 was associated with the Hyperactive index score (P=0.010).
|
28442423 |
2017 |
|
rs121908672
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To test whether increased Wnt signaling can compensate for the defect in periosteal growth caused by Bmpr1a deletion, we have generated compound mutants harboring a hyperactive mutation (A214V) in the Wnt receptor Lrp5.
|
28607813 |
2017 |
|
rs121909731
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the GDH-S445L mutation confers hyperactivity to this enzyme due to higher sensitivity to ADP allosteric activation.
|
28911206 |
2017 |
|
rs1231783932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although hyperactivity and hypersynchronicity were respectively detected in mice expressing the PS2-N141I or the APP Swedish mutant alone, the increase in cross-frequency coupling specifically characterized the 6-month-old PS2APP mice, just before the surge of the cognitive decline.
|
27889678 |
2017 |
|
rs1334791875
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ClpB-A</span>328V</span> mutant in contrast has very high ATPase activity and exhibits cellular toxicity on its own, qualifying it as novel hyperactive ClpB mutant.
|
28275610 |
2017 |
|
rs1365502141
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ClpB-A</span>328V</span> mutant in contrast has very high ATPase activity and exhibits cellular toxicity on its own, qualifying it as novel hyperactive ClpB mutant.
|
28275610 |
2017 |
|
rs1541665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, we also found rs1541665 involvement in ADHD-I subtype (OR (95% CI) = 2.341(1.713, 3.282), and Hyperactive index score (P = 0.005) in combined samples.Intriguingly, gene-environmental interactions analysis consistently revealed the potential interactionsof rs1541665 collaboratingwith maternal stress pregnancy (Pmul = 0.021) and blood lead (Padd = 0.017) to modify ADHD risk.
|
29176790 |
2017 |
|
rs1801131
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyperactivity-impulsivity score revealed association with rs5742905 'TT' and rs2236225 'CC', while rs1801133 'CC' showed association with inattentiveness and hyperactivity-impulsivity. rs1801131 exhibited strong synergistic interaction with rs1051266 and rs2236225.
|
28250422 |
2017 |
|
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyperactivity-impulsivity score revealed association with rs5742905 'TT' and rs2236225 'CC', while rs1801133 'CC' showed association with inattentiveness and hyperactivity-impulsivity. rs1801131 exhibited strong synergistic interaction with rs1051266 and rs2236225.
|
28250422 |
2017 |
|
rs2236225
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyperactivity-impulsivity score revealed association with rs5742905 'TT' and rs2236225 'CC', while rs1801133 'CC' showed association with inattentiveness and hyperactivity-impulsivity. rs1801131 exhibited strong synergistic interaction with rs1051266 and rs2236225.
|
28250422 |
2017 |
|
rs2284411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GRIN2B rs2284411 C/C genotype showed significantly better treatment response as assessed by ADHD-RS inattention ( p=0.009) and CGI-I scores ( p=0.009), and there was a nominally significant association in regard to ADHD-RS hyperactivity-impulsivity ( p=0.028) and total ( p=0.023) scores, after adjusting for age, sex, IQ, baseline Clinical Global Impression-Severity (CGI-S) score, baseline ADHD-RS total score, and final MPH dose.
|
27624150 |
2017 |
|
rs2303380
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the group composed by predominantly hyperactive/impulsive and combined presentation, the presence of LPHN3-rs6551665 G allele was related to increased ADHD risk only in individuals carrying the TTC12-rs2303380 AA genotype (p=0.026).
|
28624582 |
2017 |
|
rs2944366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our study, rs2944366 was consistently shown to be associated with the ADHD risk in the dominant model (odds ratio [OR]=0.554, 95% confidence interval [CI]=0.404-0.760), and nominally associated with Hyperactive index score (P=0.027).
|
28442423 |
2017 |
|
rs3746544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results revealed significant differential associations between two a priori loci and ADHD phenotypes, rs6296 in HTR1B with inattention and rs3746544 in SNAP-25 with hyperactivity-impulsivity.
|
28512748 |
2017 |
|
rs566794487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The previously characterized L407F mutant allele of <i>Arabidopsis</i> cry1 is biologically hyperactive and seems to mimic the ATP-bound state of cry1, but the reason for this phenotypic change is unclear.
|
28634231 |
2017 |
|
rs5742905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyperactivity-impulsivity score revealed association with rs5742905 'TT' and rs2236225 'CC', while rs1801133 'CC' showed association with inattentiveness and hyperactivity-impulsivity. rs1801131 exhibited strong synergistic interaction with rs1051266 and rs2236225.
|
28250422 |
2017 |
|
rs5918
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>ITGB3</i> coding polymorphism Leu33Pro (rs5918, Pl<sup>A2</sup>) produces hyperactive αvβ3 receptors that influence whole-blood 5-HT levels and may influence the risk for autism spectrum disorder (ASD).
|
29038237 |
2017 |
|
rs6296
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results revealed significant differential associations between two a priori loci and ADHD phenotypes, rs6296 in HTR1B with inattention and rs3746544 in SNAP-25 with hyperactivity-impulsivity.
|
28512748 |
2017 |
|
rs63750215
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although hyperactivity and hypersynchronicity were respectively detected in mice expressing the PS2-N141I or the APP Swedish mutant alone, the increase in cross-frequency coupling specifically characterized the 6-month-old PS2APP mice, just before the surge of the cognitive decline.
|
27889678 |
2017 |
|
rs63750416
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, N296H animals displayed behavioural anomalies such as hyperactivity, increased time in the open arms of the elevated plus maze and increased immobility during the tail suspension test.
|
28233851 |
2017 |
|
rs945270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicate that rs945270 might contribute to the genetic risk of ADHD partly through its effects on hyperactivity and reward processing in girls.
|
28433093 |
2017 |
|
rs9990174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, rs1170695 has been found to be associated with the ADHD risk in the addictive model (OR=1.457, 95%CI=1.173-1.809), while rs9990174 was associated with the Hyperactive index score (P=0.010).
|
28442423 |
2017 |
|
rs104895358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyper-IgD and periodic fever syndrome (HIDS) due to compound heterozygosity for G336S and V377I in a 44-year-old patient with a 27-year history of fever.
|
27899390 |
2016 |
|
rs28934897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hyper-IgD and periodic fever syndrome (HIDS) due to compound heterozygosity for G336S and V377I in a 44-year-old patient with a 27-year history of fever.
|
27899390 |
2016 |