Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057518644
rs1057518644
T 0.700 CausalMutation CLINVAR

dbSNP: rs148881970
rs148881970
G 0.700 CausalMutation CLINVAR

dbSNP: rs1553920379
rs1553920379
AAAGT 0.700 CausalMutation CLINVAR

dbSNP: rs1555582065
rs1555582065
T 0.700 CausalMutation CLINVAR

dbSNP: rs1566785444
rs1566785444
G 0.700 GeneticVariation CLINVAR

dbSNP: rs387906846
rs387906846
T 0.700 CausalMutation CLINVAR

dbSNP: rs529855742
rs529855742
A 0.700 CausalMutation CLINVAR

dbSNP: rs555145190
rs555145190
T 0.700 CausalMutation CLINVAR

dbSNP: rs587776625
rs587776625
T 0.700 CausalMutation CLINVAR

dbSNP: rs606231193
rs606231193
C 0.700 CausalMutation CLINVAR

dbSNP: rs875989800
rs875989800
G 0.700 CausalMutation CLINVAR

dbSNP: rs879253767
rs879253767
C 0.700 CausalMutation CLINVAR

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE Expression of hyperactive RAF kinases, such as the oncogenic B-RAF-V600E mutant, in normal human cells triggers a proliferative arrest that blocks tumor formation. 31371485

2019

dbSNP: rs121913377
rs121913377
0.040 GeneticVariation BEFREE Expression of hyperactive RAF kinases, such as the oncogenic B-RAF-V600E mutant, in normal human cells triggers a proliferative arrest that blocks tumor formation. 31371485

2019

dbSNP: rs104893877
rs104893877
0.040 GeneticVariation BEFREE In the present study, we reported transgenic mice with overexpressing human A53T alpha-synuclein, as well as WT mice with high dietary iron displayed hyperactive motor coordination and impaired colonic motility, compared with those with basal dietary iron. 29681846

2018

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE Fourty percent of all melanomas harbor a mutation in the signaling adaptor BRAF (V600E) that results in ERK hyperactivity as an oncogenic driver. 29983861

2018

dbSNP: rs121913377
rs121913377
0.040 GeneticVariation BEFREE Fourty percent of all melanomas harbor a mutation in the signaling adaptor BRAF (V600E) that results in ERK hyperactivity as an oncogenic driver. 29983861

2018

dbSNP: rs104893877
rs104893877
0.040 GeneticVariation BEFREE The 12-month A53T-transgenic mouse displayed hyperactive movement and anxiolytic-like behaviors with α-synuclein aggregation in midbrain. 27965467

2017

dbSNP: rs4680
rs4680
0.040 GeneticVariation BEFREE Catechol-O-methyltransferase Val158-Met polymorphism and a response of hyperactive-impulsive symptoms to methylphenidate: A replication study from South Korea. 24763183

2014

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE In colorectal cancer, BRAF V600E was described to functionally cooperate with RAC1b, a hyperactive splice variant of the small GTPase RAC1, to sustain cell survival. 23482591

2013

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE Additionally, while over-expression of mutant BRAF(V600E) increased both Mcl-1L and Mcl-1S expression, inhibition of hyperactive BRAF signalling resulted in decreased Mcl-1L expression. 24118207

2013

dbSNP: rs121913377
rs121913377
0.040 GeneticVariation BEFREE In colorectal cancer, BRAF V600E was described to functionally cooperate with RAC1b, a hyperactive splice variant of the small GTPase RAC1, to sustain cell survival. 23482591

2013

dbSNP: rs121913377
rs121913377
0.040 GeneticVariation BEFREE Additionally, while over-expression of mutant BRAF(V600E) increased both Mcl-1L and Mcl-1S expression, inhibition of hyperactive BRAF signalling resulted in decreased Mcl-1L expression. 24118207

2013

dbSNP: rs4680
rs4680
0.040 GeneticVariation BEFREE Catechol-O-methyltransferase Val158Met polymorphism and hyperactivity symptoms in Egyptian children with autism spectrum disorder. 23643763

2013

dbSNP: rs4680
rs4680
0.040 GeneticVariation BEFREE Our data suggested an association between COMT Val58Met polymorphism and hyperactivity symptoms in Egyptian children with ASD. 23643763

2013