rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF V600E and SRC mutations were mutually exclusive, and SRC mutation was significantly associated with left-sided tumor and liver metastasis compared to BRAF V600E mutation (P = 0.016 and P = 0.025, respectively).
|
30792536 |
2019 |
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF V600E and SRC mutations were mutually exclusive, and SRC mutation was significantly associated with left-sided tumor and liver metastasis compared to BRAF V600E mutation (P = 0.016 and P = 0.025, respectively).
|
30792536 |
2019 |
rs121913250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KRAS c.34G>A mutation was detected in primary tumor and liver metastasis, which additionally revealed 2 rare PI3KCA mutations (c.1633G>C and c.1645G>C).
|
29409955 |
2018 |
rs121913530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KRAS c.34G>A mutation was detected in primary tumor and liver metastasis, which additionally revealed 2 rare PI3KCA mutations (c.1633G>C and c.1645G>C).
|
29409955 |
2018 |
rs765433422
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KRAS c.34G>A mutation was detected in primary tumor and liver metastasis, which additionally revealed 2 rare PI3KCA mutations (c.1633G>C and c.1645G>C).
|
29409955 |
2018 |
rs1057519847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, patients with EGFR 19del and LM showed marginally significantly shorter OS (P = .0531) and patients with EGFR L858R and LM had OS similar to that of patients without LM (P = .1883).
|
28549835 |
2017 |
rs1057519848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, patients with EGFR 19del and LM showed marginally significantly shorter OS (P = .0531) and patients with EGFR L858R and LM had OS similar to that of patients without LM (P = .1883).
|
28549835 |
2017 |
rs121434568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, patients with EGFR 19del and LM showed marginally significantly shorter OS (P = .0531) and patients with EGFR L858R and LM had OS similar to that of patients without LM (P = .1883).
|
28549835 |
2017 |
rs121913247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, a <i>MET</i>ex14 del mutation-positive NSCLC patient who responded to crizotinib but later relapsed, demonstrated a mixed response to glesatinib including reduction in size of a <i>MET</i> Y1230H mutation-positive liver metastasis and concurrent loss of detection of this mutation in plasma DNA.<b>Conclusions:</b> Together, these data demonstrate that glesatinib exhibits a distinct mechanism of target inhibition and can overcome resistance to type I MET inhibitors.<i></i>.
|
28765324 |
2017 |
rs1345316856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cell lines stably expressing mutant PRPK (S250A), knockdown TOPK, knockdown PRPK or knockdown of both TOPK and PRPK significantly inhibited liver metastasis of human HCT116 colon cancer cells in a xenograft mouse model.
|
28412249 |
2017 |
rs1057519698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sequencing analyses of DNA from a liver metastasis biopsy sample and circulating tumor DNA both found the same I1171N ALK kinase domain mutation, known to confer resistance to certain ALK inhibitors.
|
27565911 |
2016 |
rs1057519742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report a case of a 46-year-old female with recurrent blue nevus-like melanoma of the scalp with liver metastases; mutational analysis showed GNA11 Q209L and BAP1 Q393 mutations.
|
27152652 |
2016 |
rs1057519909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Biopsy of a patient's progressing liver metastasis following prolonged response to cetuximab revealed a MEK1(K57T) mutation as a novel mechanism of acquired resistance.
|
26644315 |
2016 |
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.
|
27824903 |
2016 |
rs104886003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As a proof of the concept, we present the case of a metastatic patient with a PIK3CA wild-type primary tumor in which the PIK3CA E545K mutation was identified in both the circulating-free DNA obtained from a peripheral blood sample and in the formalin-fixed, paraffin-embedded liver metastasis.
|
26001593 |
2015 |
rs1057519803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whole-exome sequencing of the primary HER2-negative breast cancer and its HER2-negative synchronous liver metastasis from a 46-year-old female revealed the presence of an activating and clonal HER3 G284R mutation.
|
25953157 |
2015 |
rs1452020002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SMAD4 (N129K and G508D) mutations observed in P2-1, however, were nor detected in H2.
|
25623536 |
2015 |
rs397517096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
L747P (2239-2240 TT>CC) in exon 19 is a rare EGFR mutation that appears to lead to gefitinib resistance and might accelerate liver metastases.
|
26339441 |
2015 |
rs752742313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As a proof of the concept, we present the case of a metastatic patient with a PIK3CA wild-type primary tumor in which the PIK3CA E545K mutation was identified in both the circulating-free DNA obtained from a peripheral blood sample and in the formalin-fixed, paraffin-embedded liver metastasis.
|
26001593 |
2015 |
rs756090401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SMAD4 (N129K and G508D) mutations observed in P2-1, however, were nor detected in H2.
|
25623536 |
2015 |
rs758204762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whole-exome sequencing of the primary HER2-negative breast cancer and its HER2-negative synchronous liver metastasis from a 46-year-old female revealed the presence of an activating and clonal HER3 G284R mutation.
|
25953157 |
2015 |
rs773197447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SMAD4 (N129K and G508D) mutations observed in P2-1, however, were nor detected in H2.
|
25623536 |
2015 |
rs876660572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ERBB4 (T272A) mutation observed in P1-4, however, disappeared in H1.
|
25623536 |
2015 |
rs7553007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both the CRP SNP rs7553007 and KRAS/BRAF mutations were independent prognostic factors for CRC patients with synchronous liver metastasis.
|
23755178 |
2014 |
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Increased frequency of Ser/Ser genotype of hOGG1 Ser326Cys was found to be associated both with higher grade (p = 0.001, OR: 6.4; 95% CI: 2.69-62.69) and liver metastasis (p = 0.005, OR: 7.5; 95% CI: 0.7-68.36).
|
21561390 |
2011 |