Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs429358
rs429358
0.040 GeneticVariation BEFREE A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. 8024269

1994

dbSNP: rs1035071612
rs1035071612
0.010 GeneticVariation BEFREE We confirmed that the LRP C766T polymorphism was in disequilibrium with AD--the C/C genotype was present in 76% of AD patients and 60% of controls (p < 0.01); however, the LRP polymorphism did not influence age at onset of AD. 9633759

1998

dbSNP: rs1799983
rs1799983
0.030 GeneticVariation BEFREE Recently a significant association of a missense mutation (Glu298Asp) of the endothelial nitric oxide synthase (NOS3) gene with late-onset Alzheimer's disease (LOAD) was reported. 11041283

2000

dbSNP: rs1369330655
rs1369330655
0.010 GeneticVariation BEFREE In two recent studies from Germany, a strong association was found between the allelic variant T of the amino acid substitution encoding polymorphism 224 C/T (A38V) in exon 2 of the cathepsin D gene (CTSD) and late onset Alzheimer disease (AD). 11304834

2001

dbSNP: rs17571
rs17571
0.010 GeneticVariation BEFREE In two recent studies from Germany, a strong association was found between the allelic variant T of the amino acid substitution encoding polymorphism 224 C/T (A38V) in exon 2 of the cathepsin D gene (CTSD) and late onset Alzheimer disease (AD). 11304834

2001

dbSNP: rs63750207
rs63750207
0.010 GeneticVariation BEFREE No pathogenic mutations were found, but a rare non-conservative single-nucleotide polymorphism was detected in the PSEN2 gene (P334R) in a large kindred with familial late-onset AD. 11803125

2002

dbSNP: rs1799999
rs1799999
0.010 GeneticVariation BEFREE Additionally, in the dominant genetic model a marginally significant association in genotype frequencies between the Asp905Tyr PPP1R3 polymorphism and AD was observed (genotypes: OR 1.85, 95% CI 1.03 to 3.30, p = 0.04; alleles: OR 1.68, 95% CI 0.98 to 2.88, p = 0.06). 12185156

2002

dbSNP: rs3730089
rs3730089
0.010 GeneticVariation BEFREE Logistic regression analysis using the recessive genetic model showed significant differences in genotype and allelic frequencies between the AD group and normal controls (genotypes: odds ratio (OR) 2.09, 95% confidence interval (CI) 1.17 to 3.74, p = 0.01; alleles: OR 1.99, 95% CI 1.17 to 3.40, p = 0.01) for the Met326Ile PIK3R1 polymorphism that were female specific. 12185156

2002

dbSNP: rs764929617
rs764929617
0.030 GeneticVariation BEFREE Compared to E3/3 and E3/2 genotypes, the risk of developing AD associated with the genotypes carrying the e(*)4 allele, the well-established risk allele for AD onset, was observed to be high (OR=3.16; 95% CI=1.62-6.20; P=0.0009), but the risk associated with genotypes carrying the Leu28-->Pro mutation was higher still (OR=10.95; 95% CI=1.25-95.75; P=0.015). 12498968

2003

dbSNP: rs662
rs662
0.010 GeneticVariation BEFREE Different pattern of association of paraoxonase Gln192-->Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease. 12618290

2003

dbSNP: rs7493
rs7493
0.010 GeneticVariation BEFREE Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese. 14741412

2004

dbSNP: rs1799864
rs1799864
0.010 GeneticVariation BEFREE We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD. 15488313

2004

dbSNP: rs766662990
rs766662990
0.010 GeneticVariation BEFREE We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD. 15488313

2004

dbSNP: rs1805054
rs1805054
0.010 GeneticVariation BEFREE These data suggest that the HTR6 polymorphism C267T possibly involved in the susceptibility to LOAD as an APOE epsilon4-allele independent risk factor of LOAD. 15531082

2004

dbSNP: rs759223338
rs759223338
0.010 GeneticVariation BEFREE These results suggest that BACE1 gene polymorphism C7</span>86G might act as an APOE epsilon4 allele-dependent risk factor for developing LOAD in Chinese. 15784960

2005

dbSNP: rs6265
rs6265
0.020 GeneticVariation BEFREE The Val66Met (G196A), along with another C270T polymorphism has been associated with AD, however, the effects seem to be inconsistent across studies. 15843069

2005

dbSNP: rs746682028
rs746682028
0.010 GeneticVariation BEFREE The Val66Met (G196A), along with another C270T polymorphism has been associated with AD, however, the effects seem to be inconsistent across studies. 15843069

2005

dbSNP: rs759834365
rs759834365
0.010 GeneticVariation BEFREE The Val66Met (G196A), along with another C270T polymorphism has been associated with AD, however, the effects seem to be inconsistent across studies. 15843069

2005

dbSNP: rs1217691063
rs1217691063
0.050 GeneticVariation BEFREE Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease. 16055944

2005

dbSNP: rs4986790
rs4986790
0.010 GeneticVariation BEFREE Our data further support a role for innate immunity in neurodegeneration and give the first evidence that the TLR4 Asp299Gly variant may be protective toward the development of LOAD. 16157451

2006

dbSNP: rs754203
rs754203
0.010 GeneticVariation BEFREE To find new data to contribute to the evaluation of whether the presence of the T allele in the polymorphic site rs754203 of the CYP46A1 gene leads to a greater risk of developing mild cognitive impairment (MCI) and LOAD. 16340204

2006

dbSNP: rs1051338
rs1051338
0.010 GeneticVariation BEFREE We investigated two LIPA polymorphisms (rs1051338 and rs2297472) for their putative effect on the risk of LOAD in a homogenous sample of German origin. 16730122

2006

dbSNP: rs2297472
rs2297472
0.010 GeneticVariation BEFREE We investigated two LIPA polymorphisms (rs1051338 and rs2297472) for their putative effect on the risk of LOAD in a homogenous sample of German origin. 16730122

2006

dbSNP: rs2029721
rs2029721
0.010 GeneticVariation BEFREE The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003). 16832079

2006

dbSNP: rs4877365
rs4877365
0.030 GeneticVariation BEFREE A second SNP, rs4877365, which is in high linkage disequilibrium with rs4878104 (r2=0.64), was also significantly associated with LOAD (meta P=0.0017 in the initial three sample sets). 16847012

2006