|
rs11771145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No differences were found in the frequencies of ABCA7 SNP rs3764650 and EphA1 SNP rs11771145 between healthy subjects and LOAD patients.
|
31659653 |
2020 |
|
rs4147929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study showed that ABCA7 SNP rs4147929 might be a predisposing factor for LOAD.
|
31659653 |
2020 |
|
rs1012381950
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The significant variants present only in CE and TC from LOAD are UNG rs2569987 and POLβ rs1012381950, respectively.
|
31415677 |
2019 |
|
rs1223904774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The link between Val232Met variant of phospholipase D3 (PLD3) and late-onset Alzheimer's disease (AD) is still obscure.
|
31121321 |
2019 |
|
rs13306190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
APOE, MTHFR A1298C and BDNF C270T polymorphisms may be associated with LOAD and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD.
|
31102717 |
2019 |
|
rs200529365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association has been replicated in a Han Chinese cohort, two rare variants p.I163M in exon7 and p.R356H in exon11 of <i>PLD3</i> were found to be associated with LOAD risk.
|
30837833 |
2019 |
|
rs200620364
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The link between Val232Met variant of phospholipase D3 (PLD3) and late-onset Alzheimer's disease (AD) is still obscure.
|
31121321 |
2019 |
|
rs2569987
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The significant variants present only in CE and TC from LOAD are UNG rs2569987 and POLβ rs1012381950, respectively.
|
31415677 |
2019 |
|
rs387906567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We finally identified a rare nonsynonymous variant, rs572750141 (NM_030974.3:p.Gly186Arg), in SHARPIN that was potentially associated with increased risk of LOAD (corrected P = 8.05 × 10<sup>- 5</sup>, odds ratio = 6.1).
|
31216982 |
2019 |
|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
APOE, MTHFR A1298C and BDNF C270T polymorphisms may be associated with LOAD and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD.
|
31102717 |
2019 |
|
rs572750141
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We finally identified a rare nonsynonymous variant, rs572750141 (NM_030974.3:p.Gly186Arg), in SHARPIN that was potentially associated with increased risk of LOAD (corrected P = 8.05 × 10<sup>- 5</sup>, odds ratio = 6.1).
|
31216982 |
2019 |
|
rs572750141
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We finally identified a rare nonsynonymous variant, rs572750141 (NM_030974.3:p.Gly186Arg), in SHARPIN that was potentially associated with increased risk of LOAD (corrected P = 8.05 × 10<sup>- 5</sup>, odds ratio = 6.1).
|
31216982 |
2019 |
|
rs61921502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study investigated the relationship between the MSRB3 SNP rs61921502, G (minor/risk allele) and MRI measures of brain injury including total brain volume, hippocampal volume, and white matter hyperintensities using linear regression models; the presence of brain infarcts using logistic regression models; and the incidence of stroke, dementia, and AD using Cox proportional hazards models in 2,038 Framingham Heart Study Offspring participants with MRI administered close to examination cycle 7 (1998-2001).
|
30775993 |
2019 |
|
rs63750734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The link between Val232Met variant of phospholipase D3 (PLD3) and late-onset Alzheimer's disease (AD) is still obscure.
|
31121321 |
2019 |
|
rs7182283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is also significant epistatic relationship (p = 0.0410) between UNG rs80001089 and NEIL1 rs7182283 in TC from LOAD subjects.
|
31415677 |
2019 |
|
rs72824905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Amongst these, a polymorphism in phospholipase C-gamma 2 (PLCG2) P522R has been reported to be protective against LOAD.
|
30711010 |
2019 |
|
rs754618480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
APOE, MTHFR A1298C and BDNF C270T polymorphisms may be associated with LOAD and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD.
|
31102717 |
2019 |
|
rs772069024
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The link between Val232Met variant of phospholipase D3 (PLD3) and late-onset Alzheimer's disease (AD) is still obscure.
|
31121321 |
2019 |
|
rs772635342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association has been replicated in a Han Chinese cohort, two rare variants p.I163M in exon7 and p.R356H in exon11 of <i>PLD3</i> were found to be associated with LOAD risk.
|
30837833 |
2019 |
|
rs80001089
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is also significant epistatic relationship (p = 0.0410) between UNG rs80001089 and NEIL1 rs7182283 in TC from LOAD subjects.
|
31415677 |
2019 |
|
rs1050283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese.
|
29951494 |
2018 |
|
rs1050286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese.
|
29951494 |
2018 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G polymorphisms and the risk of AD in an Iranian population.
|
29072550 |
2018 |
|
rs17808009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese.
|
29951494 |
2018 |
|
rs2269657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the end, only SREBF2 polymorphism rs2269657 showed significant dual associations with LOAD pathological biomarkers and gene expression levels.
|
29503034 |
2018 |