|
rs1155002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs1155002, rs890293 and rs1805192 polymorphism are associated with increased LOAD risk.
|
27396818 |
2017 |
|
rs665640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
rs6859
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
rs11218304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
rs11622883
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
rs63750847
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A coding gene variant A673T (rs63750847) in the APP gene has recently been recognized as a protective variant of late-onset Alzheimer's Disease in a large Icelandic population and has been observed recurrently in populations from Nordic countries.
|
26239177 |
2015 |
|
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, namely C677T (rs1801133), results in increased Hcy levels and has been associated with risk of late-onset Alzheimer's disease (LOAD).
|
28211809 |
2017 |
|
rs115865530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A Novel PSEN1 K311R Mutation Discovered in Chinese Families with Late-Onset Alzheimer's Disease Affects Amyloid-β Production and Tau Phosphorylation.
|
28269784 |
2017 |
|
rs1532278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent genome-wide association study of LOAD found the strongest evidence of association with CLU at rs1532278, in high linkage disequilibrium with rs11136000.
|
24806679 |
2014 |
|
rs5984894
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A recent genome-wide study on late-onset Alzheimer's disease identified a SNP (rs5984894) on Xq21.3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States.
|
20555150 |
2010 |
|
rs7764257
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent large study has identified significant association of two single nucleotide polymorphisms (SNPs) (rs2651206 and rs7764257) in the TTBK1 gene with late-onset Alzheimer's disease (LOAD) in Spanish.
|
21219968 |
2011 |
|
rs2986017
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A recent paper reported that a variant (rs2986017) of the calcium homeostasis modulator 1 (CALHM1) gene affects risk for late-onset Alzheimer's disease (AD).
|
20164573 |
2010 |
|
rs11622883
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent study showed two polymorphisms (rs505058 in LMNA and rs11622883 near a SERPINA13 gene), identified in a genome-wide association study of late-onset Alzheimer's disease, to be associated with cognitive function (Mini Mental State Examination) in a UK elderly population.
|
21903150 |
2011 |
|
rs4877365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A second SNP, rs4877365, which is in high linkage disequilibrium with rs4878104 (r2=0.64), was also significantly associated with LOAD (meta P=0.0017 in the initial three sample sets).
|
16847012 |
2006 |
|
rs4878104
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A second SNP, rs4877365, which is in high linkage disequilibrium with rs4878104 (r2=0.64), was also significantly associated with LOAD (meta P=0.0017 in the initial three sample sets).
|
16847012 |
2006 |
|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII.
|
8024269 |
1994 |
|
rs7179008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant interaction was found between rs7179008, GT haplotype in block4 and APOE ε4 on L</span>OAD risk. rs7179008 variant also reduced the detrimental effect of smoking on LOAD risk.
|
27249957 |
2016 |
|
rs770510230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stop-gain mutation in ABCA7 (E1679X) and missense mutation in CD2AP (K633R) were highly significant in Caucasian LOAD cases, and mutations in EPHA1 (P460L) and BIN1 (K358R) were significant in Caribbean Hispanic families with LOAD.
|
26101835 |
2015 |
|
rs116754410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stop-gain mutation in ABCA7 (E1679X) and missense mutation in CD2AP (K633R) were highly significant in Caucasian LOAD cases, and mutations in EPHA1 (P460L) and BIN1 (K358R) were significant in Caribbean Hispanic families with LOAD.
|
26101835 |
2015 |
|
rs202178565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stop-gain mutation in ABCA7 (E1679X) and missense mutation in CD2AP (K633R) were highly significant in Caucasian LOAD cases, and mutations in EPHA1 (P460L) and BIN1 (K358R) were significant in Caribbean Hispanic families with LOAD.
|
26101835 |
2015 |
|
rs770461695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stop-gain mutation in ABCA7 (E1679X) and missense mutation in CD2AP (K633R) were highly significant in Caucasian LOAD cases, and mutations in EPHA1 (P460L) and BIN1 (K358R) were significant in Caribbean Hispanic families with LOAD.
|
26101835 |
2015 |
|
rs138047593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stop-gain mutation in ABCA7 (E1679X) and missense mutation in CD2AP (K633R) were highly significant in Caucasian LOAD cases, and mutations in EPHA1 (P460L) and BIN1 (K358R) were significant in Caribbean Hispanic families with LOAD.
|
26101835 |
2015 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset.
|
21784354 |
2011 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease.
|
28768149 |
2017 |