rs1012381950
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The significant variants present only in CE and TC from LOAD are UNG rs2569987 and POLβ rs1012381950, respectively.
|
31415677 |
2019 |
rs10197851
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these SNPs, 5 SNPs (rs4669573 and rs10197851 on 2p25.1; rs11711889 on 3q25.2; rs1117750 on 7p21.1; and rs7908652 on 10q23.1) were associated with LOAD in an independent cohort from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study.
|
21059989 |
2011 |
rs1035071612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We confirmed that the LRP C766T polymorphism was in disequilibrium with AD--the C/C genotype was present in 76% of AD patients and 60% of controls (p < 0.01); however, the LRP polymorphism did not influence age at onset of AD.
|
9633759 |
1998 |
rs10410544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When compared with the C allele, the T allele of rs1</span>0410544 demonstrated a 1.709-fold risk for developing LOAD.
|
24139700 |
2014 |
rs10410711
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several 19q13 single-nucleotide polymorphisms generalized the association of LOAD+P in a Caribbean Hispanic (CH) cohort, and the strongest signal was rs10410711 (pmeta = 5.1 × 10(-5)).
|
26359528 |
2015 |
rs10421862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A variant located 24 kb upstream of rs10410711 and rs10421862 was strongly associated with LOAD+P (pmeta = 1.0 × 10(-5)) in a meta-analysis of the CH cohort and an additional non-Hispanic Caucasian dataset.
|
26359528 |
2015 |
rs10498633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, our findings indicate that rs10498633 may not play a major role in LOAD susceptibility in Han Chinese.
|
27215332 |
2016 |
rs1050283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese.
|
29951494 |
2018 |
rs1050286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese.
|
29951494 |
2018 |
rs1051338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated two LIPA polymorphisms (rs1051338 and rs2297472) for their putative effect on the risk of LOAD in a homogenous sample of German origin.
|
16730122 |
2006 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset.
|
21784354 |
2011 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In two independent clinical cohorts, longer lengths of rs10524523 are associated with a higher risk for LOAD.
|
20029386 |
2010 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conclude that the poly-T repeat associations of rs10524523 in TOMM40 reflect the APOE ε4-dependent association in LOAD.
|
25500937 |
2014 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conclude that in the carriers of TOMM40-APOE haplotypes comprising E4 allele, the TOMM40 rs10524523 allele does not play substantial role in establishing LOAD risk.
|
22008263 |
2012 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) affects expression of the APOE and TOMM40 genes.
|
24439168 |
2014 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease.
|
28768149 |
2017 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant.
|
25862420 |
2015 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found a significant association between rs10524523 and risk of LOAD in APOE 33 homozygotes but in the opposite direction as the previously reported association (the very long allele was underrepresented in cases vs controls in this study (P = .004]).
|
21825236 |
2011 |
rs1059507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore explore whether the six loci in Clusterin gene (CLU) (rs9331949), Lipoprotein lipase gene (LPL) (rs1059507, rs3200218, rs3208305, rs3735964) and Low-density lipoprotein receptor related protein 6 (LRP6) (rs2160525) could modulate LOAD risk through the alteration of miRNA binding sites.
|
27897113 |
2017 |
rs1060743
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis confirmed that the "GA" haplotype derived from single-nucleotide polymorphisms in rs67327804 and rs1060743 showed a 1.4-fold increased risk of LOAD.
|
24582639 |
2014 |
rs1061170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have genotyped the common complement factor H Y402H polymorphism in a large case-control cohort to investigate association with late-onset Alzheimer's disease susceptibility and find no evidence that this SNP is associated with disease risk.
|
17999207 |
2007 |
rs10824310
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the application to the real datasets, DCL identified rs6784615, located on the NISCH gene, and rs10824310, located on the PRKG1 gene, as direct causes of late onset Alzheimer's disease (LOAD) development.
|
28363452 |
2017 |
rs10845990
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis also conferred this positive association between the SNP rs10845990 and LO</span>AD in the dominant and additive model after adjustment for age, gender, and the ApoE ε4 carrier status.
|
22421804 |
2012 |
rs10997477
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One single-nucleotide polymorphism in the promoter region (rs16923760; C allele: odds ratio, -0.74, P=.03), and a block of 4 single-nucleotide polymorphisms in intron 2 (rs1925608, C allele: 0.84, P=.04; rs7082306, A allele: 0.75, P=.04; rs1925609, T allele: 1.2, P=.03; and rs10997477, T allele: 0.88, P=.05) were associated with AD in the National Institute on Aging Late-Onset Alzheimer's Disease data set or the Caribbean Hispanic data set.
|
22393166 |
2012 |
rs10997477
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs10997477 T allele was significantly associated with a decreased risk of LOAD in APOE ε4 allele noncarriers (OR=0.750, PC<0.001).
|
24463050 |
2014 |