Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1012381950
rs1012381950
0.010 GeneticVariation BEFREE The significant variants present only in CE and TC from LOAD are UNG rs2569987 and POLβ rs1012381950, respectively. 31415677

2019

dbSNP: rs10197851
rs10197851
0.010 GeneticVariation BEFREE Of these SNPs, 5 SNPs (rs4669573 and rs10197851 on 2p25.1; rs11711889 on 3q25.2; rs1117750 on 7p21.1; and rs7908652 on 10q23.1) were associated with LOAD in an independent cohort from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study. 21059989

2011

dbSNP: rs1035071612
rs1035071612
0.010 GeneticVariation BEFREE We confirmed that the LRP C766T polymorphism was in disequilibrium with AD--the C/C genotype was present in 76% of AD patients and 60% of controls (p < 0.01); however, the LRP polymorphism did not influence age at onset of AD. 9633759

1998

dbSNP: rs10410544
rs10410544
0.010 GeneticVariation BEFREE When compared with the C allele, the T allele of rs1</span>0410544 demonstrated a 1.709-fold risk for developing LOAD. 24139700

2014

dbSNP: rs10410711
rs10410711
0.010 GeneticVariation BEFREE Several 19q13 single-nucleotide polymorphisms generalized the association of LOAD+P in a Caribbean Hispanic (CH) cohort, and the strongest signal was rs10410711 (pmeta = 5.1 × 10(-5)). 26359528

2015

dbSNP: rs10421862
rs10421862
0.010 GeneticVariation BEFREE A variant located 24 kb upstream of rs10410711 and rs10421862 was strongly associated with LOAD+P (pmeta = 1.0 × 10(-5)) in a meta-analysis of the CH cohort and an additional non-Hispanic Caucasian dataset. 26359528

2015

dbSNP: rs10498633
rs10498633
0.010 GeneticVariation BEFREE Therefore, our findings indicate that rs10498633 may not play a major role in LOAD susceptibility in Han Chinese. 27215332

2016

dbSNP: rs1050283
rs1050283
0.010 GeneticVariation BEFREE We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese. 29951494

2018

dbSNP: rs1050286
rs1050286
0.010 GeneticVariation BEFREE We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese. 29951494

2018

dbSNP: rs1051338
rs1051338
0.010 GeneticVariation BEFREE We investigated two LIPA polymorphisms (rs1051338 and rs2297472) for their putative effect on the risk of LOAD in a homogenous sample of German origin. 16730122

2006

dbSNP: rs10524523
rs10524523
0.080 GeneticVariation BEFREE A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset. 21784354

2011

dbSNP: rs10524523
rs10524523
0.080 GeneticVariation BEFREE In two independent clinical cohorts, longer lengths of rs10524523 are associated with a higher risk for LOAD. 20029386

2010

dbSNP: rs10524523
rs10524523
0.080 GeneticVariation BEFREE We conclude that the poly-T repeat associations of rs10524523 in TOMM40 reflect the APOE ε4-dependent association in LOAD. 25500937

2014

dbSNP: rs10524523
rs10524523
0.080 GeneticVariation BEFREE We conclude that in the carriers of TOMM40-APOE haplotypes comprising E4 allele, the TOMM40 rs10524523 allele does not play substantial role in establishing LOAD risk. 22008263

2012

dbSNP: rs10524523
rs10524523
0.080 GeneticVariation BEFREE We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) affects expression of the APOE and TOMM40 genes. 24439168

2014

dbSNP: rs10524523
rs10524523
0.080 GeneticVariation BEFREE A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. 28768149

2017

dbSNP: rs10524523
rs10524523
0.080 GeneticVariation BEFREE The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant. 25862420

2015

dbSNP: rs10524523
rs10524523
0.080 GeneticVariation BEFREE We found a significant association between rs10524523 and risk of LOAD in APOE 33 homozygotes but in the opposite direction as the previously reported association (the very long allele was underrepresented in cases vs controls in this study (P = .004]). 21825236

2011

dbSNP: rs1059507
rs1059507
LPL
0.010 GeneticVariation BEFREE We therefore explore whether the six loci in Clusterin gene (CLU) (rs9331949), Lipoprotein lipase gene (LPL) (rs1059507, rs3200218, rs3208305, rs3735964) and Low-density lipoprotein receptor related protein 6 (LRP6) (rs2160525) could modulate LOAD risk through the alteration of miRNA binding sites. 27897113

2017

dbSNP: rs1060743
rs1060743
0.010 GeneticVariation BEFREE Haplotype analysis confirmed that the "GA" haplotype derived from single-nucleotide polymorphisms in rs67327804 and rs1060743 showed a 1.4-fold increased risk of LOAD. 24582639

2014

dbSNP: rs1061170
rs1061170
CFH
0.010 GeneticVariation BEFREE We have genotyped the common complement factor H Y402H polymorphism in a large case-control cohort to investigate association with late-onset Alzheimer's disease susceptibility and find no evidence that this SNP is associated with disease risk. 17999207

2007

dbSNP: rs10824310
rs10824310
0.010 GeneticVariation BEFREE In the application to the real datasets, DCL identified rs6784615, located on the NISCH gene, and rs10824310, located on the PRKG1 gene, as direct causes of late onset Alzheimer's disease (LOAD) development. 28363452

2017

dbSNP: rs10845990
rs10845990
0.010 GeneticVariation BEFREE Multivariate logistic regression analysis also conferred this positive association between the SNP rs10845990 and LO</span>AD in the dominant and additive model after adjustment for age, gender, and the ApoE ε4 carrier status. 22421804

2012

dbSNP: rs10997477
rs10997477
0.020 GeneticVariation BEFREE One single-nucleotide polymorphism in the promoter region (rs16923760; C allele: odds ratio, -0.74, P=.03), and a block of 4 single-nucleotide polymorphisms in intron 2 (rs1925608, C allele: 0.84, P=.04; rs7082306, A allele: 0.75, P=.04; rs1925609, T allele: 1.2, P=.03; and rs10997477, T allele: 0.88, P=.05) were associated with AD in the National Institute on Aging Late-Onset Alzheimer's Disease data set or the Caribbean Hispanic data set. 22393166

2012

dbSNP: rs10997477
rs10997477
0.020 GeneticVariation BEFREE The rs10997477 T allele was significantly associated with a decreased risk of LOAD in APOE ε4 allele noncarriers (OR=0.750, PC<0.001). 24463050

2014