|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179).
|
21321396 |
2011 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene.
|
20739100 |
2011 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD.
|
20554627 |
2010 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CLU-rs11136000-G associated with worse baseline memory and incident MCI/LOAD.
|
25189118 |
2015 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage.
|
23643458 |
2014 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects.
|
22402018 |
2012 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known genetic risk factor for late-onset Alzheimer's disease (LOAD).
|
24806679 |
2014 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We validated the risk for LOAD with BIN1 (rs744373), CR1 (rs6656401), and ABCA7 (rs376465), as well as the protective association for MS4A6A (rs610932) and CLU (rs11136000) variants.
|
29504051 |
2018 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found by multivariate logistic regression analysis, that single nucleotide polymorphisms (SNPs) in CR1 (rs6656401 adjusted allelic p = 0.035; adjusted genotypic p = 0.043) and CLU (rs2279590 adjusted allelic p = 0.035; adjusted genotypic p = 0.006; rs11136000 adjusted allelic p = 0.038; adjusted genotypic p = 0.009) were significantly different between LOAD patients and nondemented controls.
|
22015308 |
2012 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several genome-wide association studies have found that the rs11136000 polymorphism of the C allele (CLU-C) is associated with the risk for developing late-onset Alzheimer's disease (LOAD).
|
27396407 |
2016 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer's disease and 143 control individuals.
|
22296908 |
2011 |
|
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was evidence of association for recently-reported LOAD risk loci, including BIN1 (rs7561528, p = 0.009 with, and p = 0.03 without, APOE adjustment) and CLU (rs11136000, p = 0.023 with, and p = 0.008 without, APOE adjustment), with weaker support for CR1.
|
21379329 |
2011 |
|
rs1117750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these SNPs, 5 SNPs (rs4669573 and rs10197851 on 2p25.1; rs11711889 on 3q25.2; rs1117750 on 7p21.1; and rs7908652 on 10q23.1) were associated with LOAD in an independent cohort from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study.
|
21059989 |
2011 |
|
rs11190302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When stratifying the sample by APOE one SNP (intergenic SNP rs11190302) was associated with LOAD in individuals lacking the epsilon4 allele (genotypic P = 0.027, allelic P = 0.066).
|
18452187 |
2009 |
|
rs11218304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
rs11218343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Result of the case-control study showed the association between rs11218343 polymorphism and the risk of LOAD in a Northern Han Chinese population (recessive model: odds ratio (OR) = 0.641, 95 % confidence interval (CI) = 0.464-0.884, P = 0.007; additive model: OR = 0.873, 95 % CI = 0.765-0.996, P = 0.043).
|
26873856 |
2017 |
|
rs1131445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype containing the rs266729- G and rs1501299- T alleles were associated with increased LOAD risk, OR (95%CI)= 1.83 (1.32- 2.43), and haplotype containing the rs1131445- C and rs4072111- T alleles were associated with decreased LOAD risk, OR (95%CI)= 0.53 (0.18- 0.95).
|
29108295 |
2017 |
|
rs1137101
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our preliminary data showed no significant association between the LEPR Gln223Arg polymorphism and LOAD (genotype distribution: chi=0.11, df=2, P=0.945; allele frequency: chi=0.058, df=1, P=0.81, odds ratio=1.08, 95% confidence interval=0.59 to 2.03).
|
20220325 |
2010 |
|
rs1155002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs1155002, rs890293 and rs1805192 polymorphism are associated with increased LOAD risk.
|
27396818 |
2017 |
|
rs11556505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both allelic and genotypic associations of three SNPs (rs157580, rs2075650, and rs11556505) with LOAD risk were observed in the total sample as well as in the non- APOE ε4 carriers.
|
23288655 |
2013 |
|
rs115865530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A Novel PSEN1 K311R Mutation Discovered in Chinese Families with Late-Onset Alzheimer's Disease Affects Amyloid-β Production and Tau Phosphorylation.
|
28269784 |
2017 |
|
rs11610206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrates an association of rs11610206 polymorphism locus on chromosome 12q13 with risk for LOAD in Han Chinese.
|
20883677 |
2011 |
|
rs11613092
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data indicated that 18p11.32 (rs1992269, P = 9.77 × 10(-7)), CNTNAP2 (rs802571, P = 1.26 × 10(-6)), and 12q24.23 (rs11613092, P = 6.85 × 10(-6)) were suggestive loci for susceptibility to LOAD.
|
26049409 |
2015 |
|
rs11622883
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent study showed two polymorphisms (rs505058 in LMNA and rs11622883 near a SERPINA13 gene), identified in a genome-wide association study of late-onset Alzheimer's disease, to be associated with cognitive function (Mini Mental State Examination) in a UK elderly population.
|
21903150 |
2011 |
|
rs11622883
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |