Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs41526548
rs41526548 		C 0.700 GeneticVariation GWASCAT Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. 25188341

2014
dbSNP: rs1800764
rs1800764 		0.010 GeneticVariation BEFREE Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. 28099631

2017
dbSNP: rs2200733
rs2200733 		0.010 GeneticVariation BEFREE In patients with AF, there was an association between PITX2 loci, rs2200733, and dementia (OR = 2.15, P = 0.008). 25494715

2015
dbSNP: rs8126696
rs8126696 		0.010 GeneticVariation BEFREE The rs8126696 polymorphism altered the risk of developing an α-synuclein-associated dementia. 22269890

2012
dbSNP: rs1394871591
rs1394871591
ABCA1
0.010 GeneticVariation BEFREE The amyloid beta-protein (Abeta) E22Q mutation of the rare disorder hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) causes severe cerebral amyloid angiopathy (CAA) with hemorrhagic strokes of mid-life onset and dementia. 16382777

2005
dbSNP: rs3764650
rs3764650
ABCA7
0.010 GeneticVariation BEFREE Thus, in African Americans the interactive effects of ABCA7 rs3764650 and aerobic fitness likely compound overall ABCA7-related AD risk, and may contribute to health disparities whereby African Americans are at a higher risk for dementia, with double the prevalence of AD. 31024289

2019
dbSNP: rs1401663578
rs1401663578
ACE
0.010 GeneticVariation BEFREE Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. 28099631

2017
dbSNP: rs1799752
rs1799752
ACE
0.010 GeneticVariation BEFREE As previously found for rs1799752 in ACE, rs5186 in AGTR1 was associated with dementia at baseline (OR: 3.25 [CI: 1.42-7.06], z = 2.90, p = 0.004). 27639288

2017
dbSNP: rs4291
rs4291
ACE
0.010 GeneticVariation BEFREE Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. 28099631

2017
dbSNP: rs767425642
rs767425642
ACE
0.010 GeneticVariation BEFREE The association between dementia risk and all the studied polymorphisms except of PON1-Q192R was found to be significant. 28657841

2018
dbSNP: rs2070600
rs2070600
AGER
0.010 GeneticVariation BEFREE In this study, an association was investigated in Turkish cohorts of patients with dementia with Alzheimer's Type (DAT) and MCI patients by measuring serum sRAGE levels and by genotyping G82S polymorphism and comparing them to healthy control (HC) subjects. 30389362

2019
dbSNP: rs5186
rs5186
AGTR1
0.010 GeneticVariation BEFREE As previously found for rs1799752 in ACE, rs5186 in AGTR1 was associated with dementia at baseline (OR: 3.25 [CI: 1.42-7.06], z = 2.90, p = 0.004). 27639288

2017
dbSNP: rs3764435
rs3764435
ALDH1A1
0.010 GeneticVariation BEFREE Here for the first time, we show an association between PD and rs3764435 in a Mexican mestizo population, suggesting it confers neuroprotection for dementia in PD and is neuroprotective against developing PD in the males of this population. 31649613

2019
dbSNP: rs429358
rs429358
APOE
0.030 GeneticVariation BEFREE There was no interaction between rs9331896 in CLU and rs429358 (defining the ɛ4 allele) in APOE in predicting Alzheimer's disease or all dementia (P = 0.39 and P = 0.21). 29534716

2018
dbSNP: rs429358
rs429358
APOE
0.030 GeneticVariation BEFREE When adjusted for CSF Aß42, the association of rs429358 with de</span>mentia</span> is greatly reduced but remains significant indicating that APOE polymorphism influences disease by additional mechanisms distinct from Aß42 metabolism. 20847432

2010
dbSNP: rs429358
rs429358
APOE
0.030 GeneticVariation BEFREE The apo E4 (Arg112-Cys) polymorphism has been associated with dementia and hypercholesterolemia. 11257253

2001
dbSNP: rs1233347077
rs1233347077
APOE
0.010 GeneticVariation BEFREE No association was found between the -174G>C polymorphism in the IL-6 gene and risk of dementia. 16635548

2006
dbSNP: rs405509
rs405509
APOE
0.010 GeneticVariation BEFREE The number of minor alleles in rs405509</span> or rs440446 was not associated with dementia risk (hazard ratios<1.43; 95% CI 0.87, 2.36). 30293724

2019
dbSNP: rs440446
rs440446
APOE
0.010 GeneticVariation BEFREE The number of minor alleles in rs405509 or rs</span>440446 was not associated with dementia risk (hazard ratios<1.43; 95% CI 0.87, 2.36). 30293724

2019
dbSNP: rs7412
rs7412
APOE
0.010 GeneticVariation BEFREE We reach four principal conclusion from this study: 1) rs429358 alone is responsible for the association of APOE with dementia; 2) The association of APOE with dementia is substantially mediated by its effect on CNS Aß42 levels; 3) The association of APOE with dementia is not mediated by its impact on peripheral lipid metabolism; and 4) The dichotomy of effects of rs429358 and rs7412 represents one of the best examples of genetic pleiotropy for complex traits known and illustrates the importance of allelic heterogeneity in APOE. 20847432

2010
dbSNP: rs748703149
rs748703149
APOE
0.010 GeneticVariation BEFREE In a whole-exome sequencing study of a family with probable AD-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein E (APOE) ε4 allele, we identified an extremely rare TREM2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (NM_018965.3:c.433G>T/p.[Gly145Trp]). 31464095

2020
dbSNP: rs63750066
rs63750066
APP
0.020 GeneticVariation BEFREE We describe a case of dementia clinically compatible with frontotemporal dementia in an APP Ala713Thr mutation carrier in which both [18F]Florbetapir PET uptake and Aβ1-42 cerebrospinal fluid levels were normal. 28304299

2017
dbSNP: rs63750066
rs63750066
APP
0.020 GeneticVariation BEFREE Three members of an Italian family with autosomal dominant dementia and multiple strokes had the A713T mutation of the APP gene. 15365148

2004
dbSNP: rs63751039
rs63751039
APP
0.020 GeneticVariation BEFREE The Arctic APP mutation (E693G) leads to dementia with clinical features similar to Alzheimer disease (AD), but little is known about the pathogenic mechanism of this mutation. 19329229

2011
dbSNP: rs63751039
rs63751039
APP
0.020 GeneticVariation BEFREE The Arctic APP mutation (E693G) within the amyloid β (Aβ) domain of amyloid precursor protein (APP) leads to dementia with clinical features similar to Alzheimer's disease (AD), which is believed to be mediated via increased formation of protofibrils. 21880397

2012