|
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004).
|
18853134 |
2008 |
|
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The two markers located within the TCF7L2 gene showed strong associations with T2D (rs7903146, T allele, odd ratio (OR) = 1.76, p = 0.001 and rs12255372, T allele, OR = 1.78, p = 0.002), but did not show significant association with MS.
|
20503258 |
2010 |
|
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS.
|
29971604 |
2018 |
|
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
In conclusion, the TCF7L2 rs7903146 polymorphism influences MetS risk, which is augmented by both gender and dietary SFA intake, suggesting novel gene-diet-gender interactions.
|
21543200 |
2012 |
|
rs7903146
|
|
A |
0.870 |
GeneticVariation |
GWASDB |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS.
|
21749608 |
2011 |
|
rs7903146
|
|
A |
0.870 |
GeneticVariation |
GWASCAT |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms.
|
29193419 |
2018 |
|
rs7903146
|
|
|
0.870 |
GeneticVariation |
BEFREE |
In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease.
|
19141698 |
2009 |
|
rs3764261
|
|
G |
0.830 |
GeneticVariation |
GWASDB |
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
21386085 |
2011 |
|
rs3764261
|
|
A |
0.830 |
GeneticVariation |
GWASCAT |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
rs3764261
|
|
G |
0.830 |
GeneticVariation |
GWASCAT |
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
21386085 |
2011 |
|
rs3764261
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Our data support the notion that the consumption of a Mediterranean diet may play a contributing role in triggering lipid metabolism by interacting with the rs3764261 SNP at CETP gene locus in MetS patients.
|
28057378 |
2018 |
|
rs3764261
|
|
|
0.830 |
GeneticVariation |
BEFREE |
(3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all <i>p</i> < 0.05).
|
28629169 |
2017 |
|
rs3764261
|
|
A |
0.830 |
GeneticVariation |
GWASDB |
A genome-wide association study of the metabolic syndrome in Indian Asian men.
|
20694148 |
2010 |
|
rs3764261
|
|
|
0.830 |
GeneticVariation |
BEFREE |
No significant interactions were found between rs3764261 and macronutrient intakes in association with MetS or its components.
|
29942448 |
2018 |
|
rs780094
|
|
|
0.830 |
GeneticVariation |
GWASCAT |
Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population.
|
30382898 |
2018 |
|
rs780094
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations.
|
21114848 |
2010 |
|
rs780094
|
|
A |
0.830 |
GeneticVariation |
GWASCAT |
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
22399527 |
2012 |
|
rs780094
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The GCKR rs780094 polymorphism is associated with low HDL-C levels and MetS incidence in Taiwanese adolescents.
|
26799416 |
2016 |
|
rs780094
|
|
A |
0.830 |
GeneticVariation |
GWASDB |
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
22399527 |
2012 |
|
rs780094
|
|
|
0.830 |
GeneticVariation |
GWASCAT |
New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population.
|
29632305 |
2018 |
|
rs780094
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The intragenic rs1244979, rs2815752 in NEGR1 gene, and rs780094 in GCKR gene were genotyped and CNVs were determined by droplet digital polymerase chain reaction (ddPCR) in PCOS patients (n = 153) and controls without metabolic syndrome (n = 142).
|
27878529 |
2017 |
|
rs560887
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Furthermore, we examined rs560887 for association with impaired fasting glycaemia (IFG), impaired glucose tolerance (IGT), type 2 diabetes and components of the metabolic syndrome.
|
19669124 |
2009 |
|
rs560887
|
|
|
0.820 |
GeneticVariation |
BEFREE |
No association was detected between rs7612463 (UBE2E2) and rs560887 (G6PC2) SNPs and MetS increased risk.
|
28919193 |
2017 |