rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A possible pathogenic mutation in the beta 3-adrenergic-receptor gene (Trp64Arg) has been reported to be associated with an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and clinical features of the insulin resistance syndrome in Pima Indian, Finnish and French subjects.
|
8721782 |
1996 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We recently identified a mutation in the human beta 3-adrenergic receptor (beta 3AR) gene (codon 64 TGGTrp -> CGGArg; TRP64ARG) that associates with features of the insulin resistance syndrome and an earlier onset of noninsulin-dependent diabetes mellitus (NIDDM).
|
8923875 |
1996 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is unlikely to be a major genetic predisposer to NIDDM or insulin resistance syndrome in subjects from eastern Finland.
|
9250462 |
1997 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the TRP64ARG beta 3AR variant is a susceptibility gene for several features of the insulin resistance syndrome in Mexican Americans.
|
9439659 |
1997 |
rs660339
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There were no significant differences in the allele or genotype frequencies of the Ala55Val polymorphism between 55 patients with MSDR and 46 healthy controls.
|
9724080 |
1998 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a random sample of 600 participants in the Rotterdam study, aged 55-75 years at baseline (309 men, 291 women) the relationships were studied between the presence of Trp64 Arg mutation in the beta 3-adrenergic receptor gene and fasting leptin, glucose and insulin (fasting and after an oral glucose load), and other components of the insulin resistance syndrome.
|
9828912 |
1998 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg beta3AR variant is associated in some, but not all, studies with an earlier onset of Type 2 diabetes mellitus and features of the insulin resistance syndrome.
|
10441039 |
1999 |
rs1337503417
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We studied whether there is an association between the single nucleotide polymorphism c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the metabolic syndrome in case-control and intrafamily association studies in 922 subjects from Finland and Sweden.
|
10969847 |
2000 |
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity.
|
11158005 |
2001 |
rs1805192
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|
|
0.100 |
GeneticVariation |
BEFREE |
We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity.
|
11158005 |
2001 |
rs1267969615
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although the AT1RA1166C polymorphism was not associated with any aspect of the metabolic syndrome examined, there was limited evidence to suggest that the AGT M235T polymorphism may be associated with cholesterol levels.
|
11213892 |
2001 |
rs699
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although the AT1RA1166C polymorphism was not associated with any aspect of the metabolic syndrome examined, there was limited evidence to suggest that the AGT M235T polymorphism may be associated with cholesterol levels.
|
11213892 |
2001 |
rs1232898090
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings support a role for the PPAR-gamma2 Pro12Ala variant in the etiology of type 2 diabetes and the insulin resistance syndrome.
|
11289057 |
2001 |
rs75326924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of the Pro90Ser CD36 mutation with elevated free fatty acid concentrations but not with insulin resistance syndrome in Japanese.
|
11718687 |
2001 |
rs185847354
|
|
|
0.030 |
GeneticVariation |
BEFREE |
All the subjects carrying I164T mutation showed some feature of metabolic syndrome, including hypertension, hyperlipidemia, diabetes, and atherosclerosis.
|
12086969 |
2002 |
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome.
|
12161548 |
2002 |
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome.
|
12161548 |
2002 |
rs1799883
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The Ala54Thr polymorphism of the FABP2 gene is not associated with CHD, markers of the metabolic syndrome, or the fatty acid profile of serum lipids in Finnish CHD patients.
|
12189904 |
2002 |
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate in a population-based sample of Caucasians the relation of the Pro12Ala polymorphism with plasma concentrations of FFAs and other markers of lipid and glucose metabolism described as components of the insulin resistance syndrome.
|
12354130 |
2002 |
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate in a population-based sample of Caucasians the relation of the Pro12Ala polymorphism with plasma concentrations of FFAs and other markers of lipid and glucose metabolism described as components of the insulin resistance syndrome.
|
12354130 |
2002 |
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the role of the Pro12Ala peroxisome proliferator-activated receptor (PPAR) gamma-2 polymorphism in the susceptibility to the insulin resistance syndrome and its metabolic complications in a population-based nationwide multicenter study in Spain.
|
12370112 |
2002 |
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the role of the Pro12Ala peroxisome proliferator-activated receptor (PPAR) gamma-2 polymorphism in the susceptibility to the insulin resistance syndrome and its metabolic complications in a population-based nationwide multicenter study in Spain.
|
12370112 |
2002 |
rs660339
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome.
|
12385772 |
2002 |
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome.
|
12630956 |
2003 |
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome.
|
12630956 |
2003 |