Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE A possible pathogenic mutation in the beta 3-adrenergic-receptor gene (Trp64Arg) has been reported to be associated with an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and clinical features of the insulin resistance syndrome in Pima Indian, Finnish and French subjects. 8721782

1996

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE We recently identified a mutation in the human beta 3-adrenergic receptor (beta 3AR) gene (codon 64 TGGTrp -> CGGArg; TRP64ARG) that associates with features of the insulin resistance syndrome and an earlier onset of noninsulin-dependent diabetes mellitus (NIDDM). 8923875

1996

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is unlikely to be a major genetic predisposer to NIDDM or insulin resistance syndrome in subjects from eastern Finland. 9250462

1997

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE We conclude that the TRP64ARG beta 3AR variant is a susceptibility gene for several features of the insulin resistance syndrome in Mexican Americans. 9439659

1997

dbSNP: rs660339
rs660339
0.020 GeneticVariation BEFREE There were no significant differences in the allele or genotype frequencies of the Ala55Val polymorphism between 55 patients with MSDR and 46 healthy controls. 9724080

1998

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE In a random sample of 600 participants in the Rotterdam study, aged 55-75 years at baseline (309 men, 291 women) the relationships were studied between the presence of Trp64 Arg mutation in the beta 3-adrenergic receptor gene and fasting leptin, glucose and insulin (fasting and after an oral glucose load), and other components of the insulin resistance syndrome. 9828912

1998

dbSNP: rs4994
rs4994
0.100 GeneticVariation BEFREE The Trp64Arg beta3AR variant is associated in some, but not all, studies with an earlier onset of Type 2 diabetes mellitus and features of the insulin resistance syndrome. 10441039

1999

dbSNP: rs1337503417
rs1337503417
0.040 GeneticVariation BEFREE We studied whether there is an association between the single nucleotide polymorphism c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the metabolic syndrome in case-control and intrafamily association studies in 922 subjects from Finland and Sweden. 10969847

2000

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity. 11158005

2001

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity. 11158005

2001

dbSNP: rs1267969615
rs1267969615
ACE
0.030 GeneticVariation BEFREE Although the AT1RA1166C polymorphism was not associated with any aspect of the metabolic syndrome examined, there was limited evidence to suggest that the AGT M235T polymorphism may be associated with cholesterol levels. 11213892

2001

dbSNP: rs699
rs699
AGT
0.030 GeneticVariation BEFREE Although the AT1RA1166C polymorphism was not associated with any aspect of the metabolic syndrome examined, there was limited evidence to suggest that the AGT M235T polymorphism may be associated with cholesterol levels. 11213892

2001

dbSNP: rs1232898090
rs1232898090
0.040 GeneticVariation BEFREE These findings support a role for the PPAR-gamma2 Pro12Ala variant in the etiology of type 2 diabetes and the insulin resistance syndrome. 11289057

2001

dbSNP: rs75326924
rs75326924
0.010 GeneticVariation BEFREE Association of the Pro90Ser CD36 mutation with elevated free fatty acid concentrations but not with insulin resistance syndrome in Japanese. 11718687

2001

dbSNP: rs185847354
rs185847354
0.030 GeneticVariation BEFREE All the subjects carrying I164T mutation showed some feature of metabolic syndrome, including hypertension, hyperlipidemia, diabetes, and atherosclerosis. 12086969

2002

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. 12161548

2002

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. 12161548

2002

dbSNP: rs1799883
rs1799883
0.080 GeneticVariation BEFREE The Ala54Thr polymorphism of the FABP2 gene is not associated with CHD, markers of the metabolic syndrome, or the fatty acid profile of serum lipids in Finnish CHD patients. 12189904

2002

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE To investigate in a population-based sample of Caucasians the relation of the Pro12Ala polymorphism with plasma concentrations of FFAs and other markers of lipid and glucose metabolism described as components of the insulin resistance syndrome. 12354130

2002

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE To investigate in a population-based sample of Caucasians the relation of the Pro12Ala polymorphism with plasma concentrations of FFAs and other markers of lipid and glucose metabolism described as components of the insulin resistance syndrome. 12354130

2002

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE To investigate the role of the Pro12Ala peroxisome proliferator-activated receptor (PPAR) gamma-2 polymorphism in the susceptibility to the insulin resistance syndrome and its metabolic complications in a population-based nationwide multicenter study in Spain. 12370112

2002

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE To investigate the role of the Pro12Ala peroxisome proliferator-activated receptor (PPAR) gamma-2 polymorphism in the susceptibility to the insulin resistance syndrome and its metabolic complications in a population-based nationwide multicenter study in Spain. 12370112

2002

dbSNP: rs660339
rs660339
0.020 GeneticVariation BEFREE Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome. 12385772

2002

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome. 12630956

2003

dbSNP: rs1805192
rs1805192
0.100 GeneticVariation BEFREE These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome. 12630956

2003