Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE The aim of this study was to establish associations between MetS-related abnormalities and the <i>PPAR-γ</i> rs1801282, <i>FTO</i> rs9939609, and <i>MC4R</i> rs17782313 polymorphisms. 29315078

2018

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE We investigated the association between polymorphisms rs1801282 and rs3856806 of the PPARγ gene and metabolic syndrome (MS) among Uyghurs and Kazakhs. 26125830

2015

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Combined effects of the C161T and Pro12Ala PPARγ2 gene variants with insulin resistance on metabolic syndrome: a case-control study of a central Tunisian population. 24243083

2014

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013). 24200052

2014

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE This study suggests that the PPARγ C1431T polymorphism is related to an increased risk of MetS in an Iranian population and interacts with the Pro12Ala polymorphism, further increasing the risk of MetS. 24464185

2014

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE The frequency distribution of rare alleles for PPARα (L162V) and PPARγ (P12A and H449H) was compared using the chi square test in 363 HIV-1-infected patients classified according to the presence or absence of the metabolic syndrome after 48 months of follow-up on their first PI-containing regimen. 21877956

2012

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in this study. 23145084

2012

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. 22168210

2011

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE The PPARγ2 gene single nucleotide polymorphism (SNP) Pro12Ala has shown variable association with metabolic syndrome traits in healthy subjects. 21949049

2011

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Recently, it was reported that the D2 Thr92Ala (rs225014) and the peroxisome proliferator-activated receptor (PPAR) γ2 Pro12Ala (rs1801282) polymorphisms interact in the modulation of metabolic syndrome in nondiabetic subjects. 20930717

2011

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Healthy men, in particular nonsmokers, carrying the Ala12 allele of PPARG rs1801282 polymorphism, have a high risk for MetS and IR. 19745552

2009

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE The aim of this study was to evaluate the frequency of Pro12Ala PPARgamma polymorphism and its association with body mass index (BMI) and metabolic syndrome parameters in postmenopausal Polish women. 19609844

2009

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE C1431T, but not Pro12Ala polymorphisms, are associated with MS in a Chinese population. 19237017

2009

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Our data do not support a major role for the Pro12Ala variant of the PPARG gene in MetS and its individual components. 18959602

2008

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Association of peroxisome proliferator-activated receptorgamma gene Pro12Ala and C161T polymorphisms with metabolic syndrome. 18362424

2008

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE We investigated the frequencies of two common polymorphisms of PPARgamma gene, exon 6 C-->T substitution and exon B Pro12Ala in healthy subjects and analyzed the correlations between the different genotypes and insulin resistance, metabolic syndrome and cardiovascular risk factors. 16314192

2006

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men. 17322577

2006

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE The Pro12Ala PPARG sequence variant together with a non-E3/E3 APOE genotype is associated with a high risk for postprandial hypertriglyceridemia in patients with the metabolic syndrome, indicating a close association between these genes and the regulation of lipoproteinase clearance. 16916989

2006

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Further analyses stratified on the 1431C>T single nucleotide polymorphism (SNP) indicated that the rare alleles of the P2 -689C>T and Pro12Ala SNPs were associated with an increased risk of the metabolic syndrome when combined to the 1431CC genotype. 16186413

2005

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Our objective was to search for differences in genotypes of peroxisome proliferator-activated receptor gamma (PPARgamma) (Pro12 Ala) and its coactivator PGC-1alpha (Gly482 Ser) in adolescents harboring features of metabolic syndrome. 16216916

2005

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome. 12630956

2003

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE To investigate the role of the Pro12Ala peroxisome proliferator-activated receptor (PPAR) gamma-2 polymorphism in the susceptibility to the insulin resistance syndrome and its metabolic complications in a population-based nationwide multicenter study in Spain. 12370112

2002

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE To investigate in a population-based sample of Caucasians the relation of the Pro12Ala polymorphism with plasma concentrations of FFAs and other markers of lipid and glucose metabolism described as components of the insulin resistance syndrome. 12354130

2002

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. 12161548

2002

dbSNP: rs1801282
rs1801282
0.100 GeneticVariation BEFREE We confirm an association of the P12A variant in traits commonly ascribed to the insulin resistance syndrome, but not with direct measures of insulin sensitivity. 11158005

2001