Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7903146
rs7903146
0.870 GeneticVariation BEFREE Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms. 29193419

2018

dbSNP: rs7903146
rs7903146
0.870 GeneticVariation BEFREE The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS. 29971604

2018

dbSNP: rs7903146
rs7903146
0.870 GeneticVariation BEFREE In conclusion, the TCF7L2 rs7903146 polymorphism influences MetS risk, which is augmented by both gender and dietary SFA intake, suggesting novel gene-diet-gender interactions. 21543200

2012

dbSNP: rs7903146
rs7903146
0.870 GeneticVariation BEFREE The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. 21749608

2011

dbSNP: rs7903146
rs7903146
A 0.870 GeneticVariation GWASCAT A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148

2010

dbSNP: rs7903146
rs7903146
A 0.870 GeneticVariation GWASDB A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148

2010

dbSNP: rs7903146
rs7903146
0.870 GeneticVariation BEFREE The two markers located within the TCF7L2 gene showed strong associations with T2D (rs7903146, T allele, odd ratio (OR) = 1.76, p = 0.001 and rs12255372, T allele, OR = 1.78, p = 0.002), but did not show significant association with MS. 20503258

2010

dbSNP: rs7903146
rs7903146
0.870 GeneticVariation BEFREE In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease. 19141698

2009

dbSNP: rs7903146
rs7903146
0.870 GeneticVariation BEFREE Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). 18853134

2008

dbSNP: rs3764261
rs3764261
0.830 GeneticVariation BEFREE Our data support the notion that the consumption of a Mediterranean diet may play a contributing role in triggering lipid metabolism by interacting with the rs3764261 SNP at CETP gene locus in MetS patients. 28057378

2018

dbSNP: rs3764261
rs3764261
0.830 GeneticVariation BEFREE No significant interactions were found between rs3764261 and macronutrient intakes in association with MetS or its components. 29942448

2018

dbSNP: rs780094
rs780094
0.830 GeneticVariation GWASCAT New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population. 29632305

2018

dbSNP: rs780094
rs780094
0.830 GeneticVariation GWASCAT Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population. 30382898

2018

dbSNP: rs3764261
rs3764261
0.830 GeneticVariation BEFREE (3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all <i>p</i> < 0.05). 28629169

2017

dbSNP: rs780094
rs780094
0.830 GeneticVariation BEFREE The intragenic rs1244979, rs2815752 in NEGR1 gene, and rs780094 in GCKR gene were genotyped and CNVs were determined by droplet digital polymerase chain reaction (ddPCR) in PCOS patients (n = 153) and controls without metabolic syndrome (n = 142). 27878529

2017

dbSNP: rs780094
rs780094
0.830 GeneticVariation BEFREE The GCKR rs780094 polymorphism is associated with low HDL-C levels and MetS incidence in Taiwanese adolescents. 26799416

2016

dbSNP: rs780094
rs780094
A 0.830 GeneticVariation GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527

2012

dbSNP: rs780094
rs780094
A 0.830 GeneticVariation GWASCAT Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527

2012

dbSNP: rs3764261
rs3764261
G 0.830 GeneticVariation GWASDB A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085

2011

dbSNP: rs3764261
rs3764261
G 0.830 GeneticVariation GWASCAT A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085

2011

dbSNP: rs3764261
rs3764261
A 0.830 GeneticVariation GWASDB A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148

2010

dbSNP: rs3764261
rs3764261
A 0.830 GeneticVariation GWASCAT A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148

2010

dbSNP: rs780094
rs780094
0.830 GeneticVariation BEFREE Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. 21114848

2010

dbSNP: rs560887
rs560887
0.820 GeneticVariation BEFREE No association was detected between rs7612463 (UBE2E2) and rs560887 (G6PC2) SNPs and MetS increased risk. 28919193

2017

dbSNP: rs560887
rs560887
G 0.820 GeneticVariation GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527

2012