| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.760 | GeneticVariation | BEFREE | Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. | 28882445 | 2017 |
||||
|
0.760 | GeneticVariation | BEFREE | In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. | 28119119 | 2017 |
||||
|
A | 0.760 | GeneticVariation | GWASCAT | Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. | 25802187 | 2015 |
|||
|
0.760 | GeneticVariation | BEFREE | Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance. | 24846544 | 2014 |
||||
|
0.760 | GeneticVariation | GWASCAT | A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. | 23760081 | 2013 |
||||
|
0.760 | GeneticVariation | BEFREE | We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542). | 22737229 | 2012 |
||||
|
0.760 | GeneticVariation | BEFREE | A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. | 21346778 | 2011 |
||||
|
0.760 | GeneticVariation | BEFREE | Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. | 21408128 | 2011 |