Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.760 | GeneticVariation | BEFREE | In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. | 28119119 | 2017 |
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0.760 | GeneticVariation | BEFREE | Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. | 28882445 | 2017 |
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0.760 | GeneticVariation | BEFREE | Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population. | 28613373 | 2017 |
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|
A | 0.760 | GeneticVariation | GWASCAT | Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. | 25802187 | 2015 |
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G | 0.760 | GeneticVariation | GWASCAT | A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. | 24940741 | 2014 |
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0.760 | GeneticVariation | BEFREE | Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance. | 24846544 | 2014 |
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0.760 | GeneticVariation | BEFREE | Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. | 21408128 | 2011 |
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0.760 | GeneticVariation | BEFREE | A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. | 21346778 | 2011 |