Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3077
rs3077
0.760 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. 28882445

2017

dbSNP: rs3077
rs3077
0.760 GeneticVariation BEFREE In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. 28119119

2017

dbSNP: rs9277535
rs9277535
0.760 GeneticVariation BEFREE In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. 28119119

2017

dbSNP: rs9277535
rs9277535
0.760 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. 28882445

2017

dbSNP: rs9277535
rs9277535
0.760 GeneticVariation BEFREE Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population. 28613373

2017

dbSNP: rs3077
rs3077
A 0.760 GeneticVariation GWASCAT Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. 25802187

2015

dbSNP: rs9277535
rs9277535
A 0.760 GeneticVariation GWASCAT Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. 25802187

2015

dbSNP: rs3077
rs3077
0.760 GeneticVariation BEFREE Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance. 24846544

2014

dbSNP: rs9277535
rs9277535
G 0.760 GeneticVariation GWASCAT A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. 24940741

2014

dbSNP: rs9277535
rs9277535
0.760 GeneticVariation BEFREE Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance. 24846544

2014

dbSNP: rs3077
rs3077
0.760 GeneticVariation GWASCAT A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. 23760081

2013

dbSNP: rs3077
rs3077
0.760 GeneticVariation BEFREE We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542). 22737229

2012

dbSNP: rs3077
rs3077
0.760 GeneticVariation BEFREE A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. 21346778

2011

dbSNP: rs3077
rs3077
0.760 GeneticVariation BEFREE Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. 21408128

2011

dbSNP: rs9277535
rs9277535
0.760 GeneticVariation BEFREE Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. 21408128

2011

dbSNP: rs9277535
rs9277535
0.760 GeneticVariation BEFREE A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. 21346778

2011

dbSNP: rs2856718
rs2856718
0.730 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. 28882445

2017

dbSNP: rs2856718
rs2856718
C 0.730 GeneticVariation GWASCAT Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. 25802187

2015

dbSNP: rs2856718
rs2856718
0.730 GeneticVariation BEFREE Two recent genome-wide studies showed that the single-nucleotide polymorphisms in the HLA-DQ region (rs2856718 and rs9275572) were associated with chronic hepatitis B virus infection and chronic hepatitis C virus-associated hepatocellular carcinoma in Japanese patients. 24750255

2014

dbSNP: rs2856718
rs2856718
0.730 GeneticVariation BEFREE We aimed to determine impacts of HLA-DQ polymorphisms and their interactions with HBV mutations on the risks of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). rs2856718 (A>G) and rs9275319 (A>G) were genotyped in 1342 healthy controls, 327 HBV surface antigen (HBsAg) seroclearance subjects, 611 asymptomatic HBsAg carriers (ASCs), 1144 chronic hepatitis B (CHB) patients, 734 LC patients, and 1531 HCC patients using quantitative PCR. 25281206

2014

dbSNP: rs2856718
rs2856718
0.730 GeneticVariation GWASCAT A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. 23760081

2013

dbSNP: rs7453920
rs7453920
0.720 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. 28882445

2017

dbSNP: rs7453920
rs7453920
0.720 GeneticVariation BEFREE Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population. 28613373

2017

dbSNP: rs7453920
rs7453920
A 0.720 GeneticVariation GWASCAT Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. 25802187

2015

dbSNP: rs7453920
rs7453920
G 0.720 GeneticVariation GWASCAT A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. 24940741

2014