Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. 30929061

2020

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The combination of disadvantageous allelic expression of rs6295 and rs6265 may result in a 5-HT<sub>1A</sub> receptor profile comparable to affective disorders as increased 5-HT<sub>1A</sub> receptor binding is a well published phenotype of depression. 30664620

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. 30078664

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism has been associated with increased susceptibility to develop mood disorders and recently it has been also linked with cardiovascular disease (CVD). 30347685

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism may confer risk for mood disorders in females through effects on amygdala-cortical connectivity during adolescence, coinciding with a period in the lifespan when onset of depression often occurs, more commonly in females. 28387866

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders. 28926000

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Analyzing the Effect of V66M Mutation in BDNF in Causing Mood Disorders: A Computational Approach. 28427565

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Further, 2 genetic polymorphisms: the 5-HTTLPR and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms were not directly associated with familial risk for affective disorder and did not predict illness onset. 27697135

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE However, previous genetic association studies of Val66Met polymorphism in the clinical risk of mood disorders have been complicated, possibly due to phenotypic diversity, underpowered statistical association or ancestry-specific effects. 27236043

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Four of the most consistently replicated variants associated with mood disorder occur in genes important for synaptic function: ANK3 (rs10994336), BDNF (rs6265), CACNA1C (rs1006737), and DGKH (rs1170191). 24944871

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF polymorphism, val66met, has also been implicated in mood disorders. 24398043

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The aim of this study was to investigate whether BDNF alone or in interaction with the BDNF Val66Met polymorphism predict onset of affective disorder in healthy individuals at heritable risk for affective disorder. 24112874

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders. 24607934

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Studies have indicated that a functional polymorphism (Val66Met) in a brain-derived neurotrophic factor (BDNF) gene can influences human cognitive functions and mood disorders. 23823988

2013

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The brain-derived neurotrophic factor (BDNF) Val(66) Met allelic variation is linked to both the occurrence of mood disorders and antidepressant response. 22225729

2012

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The effect of the Val66Met polymorphism on synaptic transmission and plasticity in the IL-mPFC represents a mechanism to account for this impact of SNP on affective disorders and cognitive dysfunction. 22396415

2012

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function. 19931400

2010

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Individuals at high risk of affective disorders and who are carriers of the met allele of the Val66Met polymorphism may present with an enhanced stress response. 19473771

2009

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Individuals with schizoaffective disorder and other affective disorders were significantly more likely to carry two copies of the most common BDNF haplotype (containing the valine allele of the Val66Met polymorphism) compared with healthy volunteers. 19336781

2009

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Given that stress-induced atrophy of the hippocampus is associated with the pathogenesis of affective disorders, the functional BDNF Val66Met polymorphism could be an incremental risk factor. 19335934

2009

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. 19018714

2008

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Further investigations in larger samples are needed to clarify the usefulness of 5-HTTLPR and BDNF Val66Met genotyping in the optimization of non-pharmacological treatments in mood disorders. 18450378

2008

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE In the present study, we evaluated the impact of the BDNF Val66Met polymorphism on individual differences in personality traits in a sample of healthy volunteers in relation to other common gene variants thought to be involved in the pathophysiology of affective disorders, such as the serotonin transporter promoter polymorphism (5-HTTLPR) and a variable number of tandem repeat polymorphism of the dopamine transporter gene (DAT VNTR). 17392738

2007

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects. 16649215

2006

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. 15770238

2005