Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1215600806
rs1215600806
0.010 GeneticVariation BEFREE Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA. 31146036

2019

dbSNP: rs1215600806
rs1215600806
0.010 GeneticVariation BEFREE Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA. 31146036

2019

dbSNP: rs1273593548
rs1273593548
0.010 GeneticVariation BEFREE <b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation. 31126199

2019

dbSNP: rs1416572796
rs1416572796
0.010 GeneticVariation BEFREE Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA. 31146036

2019

dbSNP: rs143358506
rs143358506
0.010 GeneticVariation BEFREE Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA. 31146036

2019

dbSNP: rs143358506
rs143358506
0.010 GeneticVariation BEFREE Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA. 31146036

2019

dbSNP: rs231755
rs231755
0.010 GeneticVariation BEFREE The genotypic association analyses showed that the CTLA4 rs231755 was associated with osteosarcoma susceptibility in the Spanish population. 28052683

2019

dbSNP: rs3217992
rs3217992
0.010 GeneticVariation BEFREE RESULTS An allele of the SNP rs3217992 is predictive for susceptibility to osteos</span>arcoma, and it is associated with poorer prognosis of osteos</span>arcoma. 30774116

2019

dbSNP: rs367597251
rs367597251
0.010 GeneticVariation BEFREE <b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation. 31126199

2019

dbSNP: rs4730222
rs4730222
0.010 GeneticVariation BEFREE We show that the most significant SNP, rs4730222, exhibits differential nuclear protein binding in electrophoretic mobility shift assays and drives increased expression of an alternative isoform of HBP1 in a heterozygote chondrosarcoma cell line, in a CRISPR-edited osteosarcoma cell line, and in chondrocytes derived from osteoarthritis patients. 31164647

2019

dbSNP: rs756673959
rs756673959
0.010 GeneticVariation BEFREE <b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation. 31126199

2019

dbSNP: rs764191858
rs764191858
0.010 GeneticVariation BEFREE Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA. 31146036

2019

dbSNP: rs770771727
rs770771727
0.010 GeneticVariation BEFREE Fresh mitochondria isolated from homeoplasmic 143B osteosarcoma cybrids containing mitochondrial DNA (mtDNA) derived from health individuals (Mito) or mtDNA with the A8344G mutation (Mito<sup>8344</sup>) were conjugated with cell-penetrating peptide Pep-1 (P-Mito) or not conjugated prior to cell co-culture. 30674338

2019

dbSNP: rs779591039
rs779591039
0.010 GeneticVariation BEFREE Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA. 31146036

2019

dbSNP: rs12879262
rs12879262
0.010 GeneticVariation BEFREE Four polymorphisms in pre-miRNAs at 14q32 miRNA cluster were associated with osteosarcoma risk in the Spanish population (rs12894467, rs61992671, rs58834075 and rs12879262). 30337581

2018

dbSNP: rs12894467
rs12894467
0.010 GeneticVariation BEFREE Four polymorphisms in pre-miRNAs at 14q32 miRNA cluster were associated with osteosarcoma risk in the Spanish population (rs12894467, rs61992671, rs58834075 and rs12879262). 30337581

2018

dbSNP: rs1295925
rs1295925
0.010 GeneticVariation BEFREE We found that rs1295925 (OR = 0.85; 95 CI = 0.76-0.94; P = 0.003) and rs3787547 (OR = 1.27; 95 CI = 1.11-1.45; P = 4.0 × 10<sup>-4</sup>) was significantly with OS susceptibility. 29595404

2018

dbSNP: rs145204276
rs145204276
0.010 GeneticVariation BEFREE The genetic variant rs145204276 is functionally associated with the susceptibility of OS, which can function as a protective factor in the incidence of OS possibly through the regulation of GAS5. 30013899

2018

dbSNP: rs171140
rs171140
0.010 GeneticVariation BEFREE ERCC1 (C118T (rs11615) and C8092A (rs3212986)) and ERCC2 (A751C (rs171140) and G312A (rs1799793)) polymorphisms were analysed in 44 patients with osteosarcoma, who were treated with cisplatin based neoadjuvant chemotherapy. 29980176

2018

dbSNP: rs1799782
rs1799782
0.010 GeneticVariation BEFREE Besides, no significant association of rs25487, rs1799782, and rs25489 with OS was observed. 30464596

2018

dbSNP: rs2296147
rs2296147
0.010 GeneticVariation BEFREE Our meta-analysis indicated that TT genotype in the <i>ERCC2</i> rs1799793 and <i>ERCC5</i> rs2296147 might prolong the survival time of patients with osteosarcoma, suggesting that the rs1799793 and rs2296147 polymorphisms can be used as predictors for prognosis of osteosarcoma patients treated with chemotherapy. 29950854

2018

dbSNP: rs25489
rs25489
0.010 GeneticVariation BEFREE Besides, no significant association of rs25487, rs1799782, and rs25489 with OS was observed. 30464596

2018

dbSNP: rs3213245
rs3213245
0.010 GeneticVariation BEFREE In conclusion, these findings revealed that XRCC1 rs3213245 polymorphism was associated with increased risk of OS, which could affect XRCC1 expression in vitro and in vivo. 30464596

2018

dbSNP: rs3787547
rs3787547
0.010 GeneticVariation BEFREE We found that rs1295925 (OR = 0.85; 95 CI = 0.76-0.94; P = 0.003) and rs3787547 (OR = 1.27; 95 CI = 1.11-1.45; P = 4.0 × 10<sup>-4</sup>) was significantly with OS</span> susceptibility. 29595404

2018

dbSNP: rs3821204
rs3821204
0.010 GeneticVariation BEFREE These findings suggest that the rs7025417 and rs3821204 may have a combined effect to protect against the development of OS by decreasing the expression levels of IL-33 or ST2. 29797504

2018