|
rs58834075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four polymorphisms in pre-miRNAs at 14q32 miRNA cluster were associated with osteosarcoma risk in the Spanish population (rs12894467, rs61992671, rs58834075 and rs12879262).
|
30337581 |
2018 |
|
rs7025417
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that the rs7025417 and rs3821204 may have a combined effect to protect against the development of OS by decreasing the expression levels of IL-33 or ST2.
|
29797504 |
2018 |
|
rs756340448
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ERCC1 (C118T (rs11615) and C8092A (rs3212986)) and ERCC2 (A751C (rs171140) and G312A (rs1799793)) polymorphisms were analysed in 44 patients with osteosarcoma, who were treated with cisplatin based neoadjuvant chemotherapy.
|
29980176 |
2018 |
|
rs8103992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An expression quantitative trait locus for cartilage intermediate layer protein 2 (CILP2), rs8103992, was significantly associated with osteosarcoma risk after adjustment for multiple comparisons (odds ratio, 1.35; 95% CI, 1.16-1.56 [P = 7.93×10<sup>-5</sup> and P<sub>adjusted</sub> =.034]).
|
30311632 |
2018 |
|
rs12190287
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CG and GG genotypes of rs12190287 predict elevated risk of osteosarcoma.
|
28663539 |
2017 |
|
rs1253660442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Even though the role of single nucleotide polymorphisms of ATIC in chemotherapy-induced tumor necrosis has not been investigated yet, the ATIC 347C>G polymorphism may influence the levels of adenosine after MTX treatment, which may affect the histologic response of osteosarcoma.
|
28267080 |
2017 |
|
rs17111750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study was designed to determine whether APE1 polymorphisms (rs1130409, rs1760944, rs1760941, rs2275008, rs17111750) are associated with OS.
|
28839218 |
2017 |
|
rs1760944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggested that APE1 rs1760944 polymorphism is associated with decreased risk of developing OS and better survival of OS patients.
|
28839218 |
2017 |
|
rs217727
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This finding indicates that rs217727 polymorphism may play a role in genetic susceptibility to the risk of osteosarcoma, which may improve our understanding of the potential contribution of H19 SNPs to cancer pathogenesis.
|
28975992 |
2017 |
|
rs2275008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study was designed to determine whether APE1 polymorphisms (rs1130409, rs1760944, rs1760941, rs2275008, rs17111750) are associated with OS.
|
28839218 |
2017 |
|
rs2372536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Even though the role of single nucleotide polymorphisms of ATIC in chemotherapy-induced tumor necrosis has not been investigated yet, the ATIC 347C>G polymorphism may influence the levels of adenosine after MTX treatment, which may affect the histologic response of osteosarcoma.
|
28267080 |
2017 |
|
rs6218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of TC and CC genotypes of rs6218 indicated higher risk of osteosarcoma.
|
29232358 |
2017 |
|
rs745738344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms.
|
29228633 |
2017 |
|
rs747126003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms.
|
29228633 |
2017 |
|
rs10019009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a functional analysis of rs10019009 via reverse transcription-polymerase chain reaction, alkaline phosphatase (ALP) activity in human osteosarcoma U 2 OS cells.
|
26960368 |
2016 |
|
rs1056629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to explore the roles of microRNA-491-5p (miR-491) and its target MMP9 in the control of metastasis of osteosarcoma (OS) as well as how the rs1056629 polymorphism in the 3' untranslated region (3'UTR) of MMP9 compromises the interaction between miR-491 and MMP9.
|
27023472 |
2016 |
|
rs11556218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that rs11556218 TG/GG genotypes may be associated with increased susceptibility to OS, probably by increasing the production of IL16 level.
|
27703190 |
2016 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the genotype and allele frequencies of IL-10 -819C/T (rs1800871) and -592A/C (rs1800872) polymorphisms in osteosarcoma patients did not significantly differ from controls.
|
26503210 |
2016 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the genotype and allele frequencies of IL-10 -819C/T (rs1800871) and -592A/C (rs1800872) polymorphisms in osteosarcoma patients did not significantly differ from controls.
|
26503210 |
2016 |
|
rs1800896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, a statistically significant association between the IL-10 -1082A/G (rs1800896) genotype and poor survival in osteosarcoma</span> patients was observed.
|
26503210 |
2016 |
|
rs1872328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first study replicating the association of ACYP2 variant rs1872328 with cisplatin-induced ototoxicity in patients with osteosarcoma who did not receive potentially ototoxic cranial irradiation.
|
26928270 |
2016 |
|
rs1989839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, rs1989839C/T is also associated with the Enneking stage of osteosarcoma and risk of lung metastasis.
|
27880743 |
2016 |
|
rs1989839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CT genotype of rs1989839 is highly related to elevated risk of osteosarcoma.
|
27880743 |
2016 |
|
rs2236947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One of the other 4 SNPs, rs2236947A/C, shows a borderline significance in predicting osteosarcoma risk.
|
27880743 |
2016 |
|
rs243865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MMP2 rs243865 genotype was associated with increased risk for development of osteosarcoma in Chinese Han population.
|
26754027 |
2016 |