|
rs777980327
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We propose that continuously activated BRAF(V600E) signaling may be a possible mechanism for the deregulation of Mps1 stability and kinase activity in human tumors, and that persistent phosphorylation of Mps1 through BRAF(V600E) signaling is a key event in disrupting the control of centrosome duplication and chromosome stability that may contribute to tumorigenesis.
|
22430208 |
2013 |
|
rs777980327
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The increased incidence of cancer in FDRs of index CRC patients with the p.V600E BRAF mutation may be explained by a genetic predisposition to develop cancer through the serrated pathway of colorectal carcinogenesis.
|
20570909 |
2010 |
|
rs1801166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These data support a novel mechanism in which p.Glu1317Gln in combination with other weak mutant APC alleles (generating polypepetides with zero, two, or three 20AARs) can provide the necessary growth advantage for colorectal tumorigenesis.
|
19701947 |
2009 |
|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To assess the risk of this common APC allelic variant in colorectal carcinogenesis, a cohort of unselected Turkish subjects with stomach or colorectal cancer (or both) was analyzed for the APC I1307K polymorphism.
|
17854661 |
2007 |
|
rs1801155
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To assess the risk of this common APC allelic variant in colorectal carcinogenesis, a cohort of unselected Turkish subjects with stomach or colorectal cancer (or both) was analyzed for the APC I1307K polymorphism.
|
17854661 |
2007 |
|
rs1801166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, when we used normal colonoscopy controls (E1317Q carrier frequency = 0.3%), the prevalence of E1317Q was significantly increased in CRC patients, in patients with < or =3 adenomas, and in CRC patients with intact mismatch repair status, suggesting a possible role for E1317Q in colorectal tumorigenesis.
|
14578138 |
2003 |
|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To assess the role in tumorigenesis of the variant (A)8 tract produced by this allele, we undertook a somatic mutation analysis of the region surrounding codon 1307 in colorectal tumors from APC I1307K carriers.
|
9751605 |
1998 |
|
rs1801155
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To assess the role in tumorigenesis of the variant (A)8 tract produced by this allele, we undertook a somatic mutation analysis of the region surrounding codon 1307 in colorectal tumors from APC I1307K carriers.
|
9751605 |
1998 |
|
rs137854573
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The mutation of APC (rs137854573, c.C1606T, p.R536X) could result in HB carcinogenesis by activating Wnt signaling.
|
30619485 |
2018 |
|
rs137854574
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The mutation of APC (rs137854573, c.C1606T, p.R536X) could result in HB carcinogenesis by activating Wnt signaling.
|
30619485 |
2018 |
|
rs2229992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study we analyzed the association of genotype and haplotype status of two single nucleotide polymorphisms (SNPs), rs2229992 and rs11283943, in the APC and MCC genes, respectively, with an increased risk of breast carcinogenesis in a breast cancer and control population from eastern India.
|
21279955 |
2011 |