Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1444669684
rs1444669684
0.020 GeneticVariation BEFREE The data suggest that coexpression of BRAF(V600E) and KRAS(G12D) in early tumorigenesis leads to negative selection due to oncogene-induced senescence. 26028035

2016

dbSNP: rs1444669684
rs1444669684
0.020 GeneticVariation BEFREE Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.). 24213573

2014

dbSNP: rs771138120
rs771138120
0.020 GeneticVariation BEFREE These data suggest that the changes in the regulatory 'hot-spot' on the CDK4 gene, causing various endocrine tumours in CDK4(R24C/R24C )mice, are not a major factor in sporadic pituitary, insulin beta-cell or Leydig cell tumorigenesis. 12904177

2003

dbSNP: rs771138120
rs771138120
0.020 GeneticVariation BEFREE Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence. 11756559

2002

dbSNP: rs1390902532
rs1390902532
0.010 GeneticVariation BEFREE XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis. 21234761

2011