rs147001633
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The R882H mutation causes a reduction in DNA methyltransferase activity and hypomethylation at differentially-methylated regions within the genome, ultimately preventing hematopoietic stem cell differentiation and leading to leukemogenesis.
|
31582562 |
2019 |
rs147001633
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Molecularly, both DNMT3A-WT and R882H/C mutants interacted with PRDX2; and R882C/H mutation-induced hypomethylation increased PRDX2 expression which enhanced cell proliferation and growth with impairment of apoptosis, thereby contributing to leukemogenesis.
|
30245403 |
2018 |
rs147001633
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Moreover, DNMT3A-R882H increased the CDK1 protein level and enhanced cell-cycle activity, thereby contributing to leukemogenesis.
|
24497509 |
2014 |
rs387907272
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genetically, PA-DLBCL harbored a high prevalence of MYD88 L265P (24%) and CD79B mutations (52%) which may be involved in lymphomagenesis.
|
31609782 |
2020 |
rs121913237
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
|
31703632 |
2019 |
rs387907272
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In order to evaluate whether the presence of the recently described MYD88 L265P mutation in patients with Waldenström's macroglobulinemia (WM) is contributory to SS-associated lymphomagenesis, a quantitative allele-specific PCR method was performed in peripheral blood derived from 90 SS patients as well as in minor salivary gland tissues derived from 12 primary SS patients with or without lymphoma.
|
24153350 |
2014 |
rs121913237
|
|
|
0.020 |
GeneticVariation |
BEFREE |
It is thus unclear how Nras(G12D/+) signaling promotes leukemogenesis.
|
23687087 |
2013 |
rs121912472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus our studies provide clues in understanding the leukemogenesis of JAK2 K607N mutation in AML.
|
30521925 |
2019 |
rs2239630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This suggests CEBPE regulates a similar set of genes in each, consistent with a common biological mechanism of leukemogenesis for rs2239630 associated and CEBPE translocated ALL.
|
29977016 |
2019 |
rs9277378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genome-wide association study reports strongest association of HLA-DPB1 rs9277378 with lymphomagenesis.
|
31187536 |
2019 |
rs371769427
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In an attempt to identify <i>U2af1</i>(S34F)-cooperating changes that promote leukemogenesis, we combined <i>U2af1</i>(S34F) with <i>Runx1</i> deficiency in mice and further treated the mice with a mutagen, <i>N</i>-ethyl-<i>N</i>-nitrosourea (ENU).
|
30322915 |
2018 |
rs377577594
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Molecularly, both DNMT3A-WT and R882H/C mutants interacted with PRDX2; and R882C/H mutation-induced hypomethylation increased PRDX2 expression which enhanced cell proliferation and growth with impairment of apoptosis, thereby contributing to leukemogenesis.
|
30245403 |
2018 |
rs10251201
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses.
|
28375557 |
2017 |
rs10405859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses.
|
28375557 |
2017 |
rs9318227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses.
|
28375557 |
2017 |
rs974120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses.
|
28375557 |
2017 |
rs397507510
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified TET2 and PTPN11 mutations in both mouse and human AML and then demonstrated the ability of Tet2 loss and PTPN11 D61Y to initiate leukemogenesis in concert with expression of AML1-ETO in vivo.
|
26666262 |
2016 |
rs757412228
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified TET2 and PTPN11 mutations in both mouse and human AML and then demonstrated the ability of Tet2 loss and PTPN11 D61Y to initiate leukemogenesis in concert with expression of AML1-ETO in vivo.
|
26666262 |
2016 |
rs1190999960
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
rs1217007648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Transcription activator-like effector nuclease-based knock-in mutagenesis provides evidence from a B lymphoid context that K171E IKKβ contributes to lymphomagenesis.
|
25107905 |
2014 |
rs1250394819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
rs1483790387
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
rs267601394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, EZH2(Y641F) can collaborate with Myc to accelerate lymphomagenesis demonstrating a cooperative role of EZH2 mutations in oncogenesis.
|
24802772 |
2014 |
rs568887534
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, p27 mutations that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis over wild-type p27, validating the tumor-suppressor function of nuclear p27 in CML.
|
25293778 |
2014 |
rs373667881
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This R107L mutation remained in leukocytes of the remission stage in which GATA1 mutation disappeared, suggesting the TRIB1 mutation is an earlier genetic event in leukemogenesis.
|
22294728 |
2012 |