DisGeNET - a database of gene-disease associations

Prostate carcinoma, C0600139

Gene: PCAT1 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs16901979

PCAT1 ; CASC19

0.800

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs16901979

PCAT1 ; CASC19

0.800

GeneticVariation

BEFREE

We report that rs7008482, which maps to the 8q24.13 region, is an additional independent prostate cancer risk variant (P = 5 x 10(-4)), and we also replicate the association of rs16901979 with prostate cancer (P = 0.002).

17978284

2007

dbSNP:

rs6983267

POU5F1B ; CASC8 ; PCAT1 ; CCAT2

0.800

GeneticVariation

BEFREE

Analysis of the National Cancer Institute's Cancer Genetic Markers of Susceptibility (CGEMS) prostate cancer association study database alone and in combination with our data provided further evidence for this second prostate cancer risk locus; in the combined analysis, the allele frequencies for rs6983267 differed statistically significantly between case patients and control subjects (P = 1.61 x 10(-9)).

17925536

2007

dbSNP:

rs6983267

POU5F1B ; CASC8 ; PCAT1 ; CCAT2

0.800

GeneticVariation

BEFREE

A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 x 10(-13); heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13-1.41; homozygote OR: 1.58, 95% c.i.: 1.40-1.78).

17401363

2007

dbSNP:

rs6983267

POU5F1B ; CASC8 ; PCAT1 ; CCAT2

0.800

GeneticVariation

GWASCAT

17401363

2007

dbSNP:

rs1016342

PCAT1 ; PRNCR1 ; CASC19 ; PCAT2

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs1016343

PCAT1 ; PRNCR1 ; CASC19 ; PCAT2

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs1031588

PCAT1 ; PRNCR1 ; CASC19 ; PCAT2

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs1378897

PCAT1 ; CASC19

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs1456305

PCAT1 ; CASC19

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs1456306

PCAT1 ; CASC19

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs1456314

PCAT1

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs1551510

PCAT1 ; PRNCR1 ; CASC19 ; PCAT2

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs17831626

PCAT1

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs6470494

PCAT1 ; CASC19 ; PCAT2

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs6993569

PCAT1

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs6994316

PCAT1 ; PCAT2

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs7816535

PCAT1 ; CASC19

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs7825414

PCAT1

0.700

GeneticVariation

GWASCAT

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

17401366

2007

dbSNP:

rs16901979

PCAT1 ; CASC19

0.800

GeneticVariation

BEFREE

There was no joint effect between SNPs rs16901979 A and rs6983267 G. These results confirm the significance of these SNPs in prostate cancer etiology in a previously unstudied population who do not undergo prostate cancer screening and are diagnosed with severe disease.

18768513

2008

dbSNP:

rs16901979

PCAT1 ; CASC19

0.800

GeneticVariation

BEFREE

A meta-analysis across 10 studies including our results of four 8q24 variants (rs1442295 and DG8S737-region 1, rs16901979-region 2, and rs6983267-region 3) and prostate cancer risk demonstrated strong associations across a wide array of study designs and populations.

18231127

2008

dbSNP:

rs6983267

POU5F1B ; CASC8 ; PCAT1 ; CCAT2

0.800

GeneticVariation

BEFREE

The rs6983267 G allele did not show significant association with susceptibility to PC (PC vs. non-PC: P = 0.967; OR, 1.00; 95%CI = 0.83-1.21).

18726982

2008

dbSNP:

rs6983267

POU5F1B ; CASC8 ; PCAT1 ; CCAT2

0.800

GeneticVariation

BEFREE

18231127

2008

dbSNP:

rs6983267

POU5F1B ; CASC8 ; PCAT1 ; CCAT2

0.800

GeneticVariation

BEFREE

Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association.

18360876

2008

dbSNP:

rs6983267

POU5F1B ; CASC8 ; PCAT1 ; CCAT2

0.800

GeneticVariation

GWASCAT

Multiple loci identified in a genome-wide association study of prostate cancer.

18264096

2008