|
rs964184
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between rs964184 and prostate cancer risk was stronger among homozygous carriers of the minor allele (OR = 0.27; 95% CI: 0.09, 0.83).
|
24623848 |
2014 |
|
rs1290923018
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.
|
12954644 |
2003 |
|
rs7210100
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
|
21602798 |
2011 |
|
rs7210100
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Of the 82 known risk variants, 68 (83%) had effects that were directionally consistent in their association with prostate cancer risk and 30 (37%) were significantly associated with risk at p < 0.05, with the most statistically significant variants being rs116041037 (p = 3.7 × 10(-26) ) and rs6983561 (p = 1.1 × 10(-16) ) at 8q24, as well as rs7210100 (p = 5.4 × 10(-8) ) at 17q21.
|
25044450 |
2015 |
|
rs116890317
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two ZNF652 (17q21.3) variants, rs116890317 and rs79670217, increased the risk of both sporadic and hereditary PrCa (rs116890317: OR = 3.3-7.8, p = 0.003-3.3 × 10(-5) ; rs79670217: OR = 1.6-1.9, p = 0.002-0.009).
|
25335771 |
2015 |
|
rs79670217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two ZNF652 (17q21.3) variants, rs116890317 and rs79670217, increased the risk of both sporadic and hereditary PrCa (rs116890317: OR = 3.3-7.8, p = 0.003-3.3 × 10(-5) ; rs79670217: OR = 1.6-1.9, p = 0.002-0.009).
|
25335771 |
2015 |
|
rs73046248
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.
|
31095341 |
2020 |
|
rs77911174
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We found 12 novel loci for PCa including rs1125927 (TMEM17, P = 3.95 × 10<sup>-16</sup>), rs73862213 (GATA2, P = 5.87 × 10<sup>-23</sup>), rs77911174 (ZMIZ1, P = 5.28 × 10<sup>-20</sup>), and rs138708 (SUN2, P = 1.13 × 10<sup>-15</sup>), seven of which had crucially low minor allele frequency in European population.
|
31562322 |
2019 |
|
rs77911174
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
We found 12 novel loci for PCa including rs1125927 (TMEM17, P = 3.95 × 10<sup>-16</sup>), rs73862213 (GATA2, P = 5.87 × 10<sup>-23</sup>), rs77911174 (ZMIZ1, P = 5.28 × 10<sup>-20</sup>), and rs138708 (SUN2, P = 1.13 × 10<sup>-15</sup>), seven of which had crucially low minor allele frequency in European population.
|
31562322 |
2019 |
|
rs6062509
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
rs6062509
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
|
23535732 |
2013 |
|
rs7064929
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
|
20932654 |
2010 |
|
rs6763931
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
|
21743467 |
2011 |
|
rs6763931
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
rs6869366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis.
|
23321468 |
2013 |
|
rs28360071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggested that the variant genotype of XRCC4 rs28360071 and rs28360317 and haplotype analysis may be associated with PCa risk.
|
21506695 |
2011 |
|
rs28360071
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis.
|
23321468 |
2013 |
|
rs1805377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, significant association was maintained in prostate cancer (rs28360071), lung cancer (rs6869366) and bladder cancer (rs1805377) subgroups analysis.
|
23321468 |
2013 |
|
rs28360317
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggested that the variant genotype of XRCC4 rs28360071 and rs28360317 and haplotype analysis may be associated with PCa risk.
|
21506695 |
2011 |
|
rs3218536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms (SNPs) in the genes involved in HRR, that is, RAD51 (rs1801320 and rs1801321), RAD51B (rs10483813 and rs3784099), XRCC2 (rs3218536), and XRCC3 (rs861539).
|
26339569 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, our results also suggested that XRCC1 Arg399Gln polymorphism was not significantly associated with pr</span>ostate cancer in white men.
|
19428062 |
2009 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the XRCC1-Arg399Gln AA and the MGMT-Leu84Phe CT+TT genotypes were associated with an increased risk of prostate cancer [odds ratio (OR), 2.18; 95% confidence interval (CI), 0.99-4.81 and OR, 1.99; 95% CI, 1.19-3.34, respectively].
|
16030105 |
2005 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine whether the XRCC1 (codon Arg399Gln) and XPD (codon Asp312Asn and codon Lys751Gln) polymorphisms are associated with prostate cancer susceptibility, we genotyped these polymorphisms in a primarily Caucasian sample of 506 sibships (n = 1,117) ascertained through a brother with prostate cancer.
|
14744728 |
2004 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the association between PC risk with nonsynonymous SNPs (nsSNPs) in 5 genes involved in 3 DNA-repair pathways: (1) base excision repair (BER): hOGG1 C1245G (Ser326Cys) and XRCC1 G28152A (Arg399Gln); (2) nucleotide excision repair (NER): XPD G23591A (Asp312Asn); (3) homologous recombination repair: RAD51 G135C (in 5' untranslated region) and XRCC3 C18067T (Thr241Met).
|
19914098 |
2012 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this meta-analysis, we found that both Arg399Gln and Arg194Trp polymorphisms were not related to overall PCa risk.
|
21647176 |
2011 |