|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, loci associated with risk for prostate cancer, such as rs7920517 and rs10993994, might also be used to predict the recurrence of prostate-specific antigen in prostate cancer patients receiving radical prostatectomy.
|
19900942 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Cells with prostate cancer risk alleles at rs10993994 seem to cope more efficiently with DNA double strand breaks (less MN) in a shorter time (decreased MD index).
|
22677538 |
2012 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.
|
20717903 |
2011 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans).
|
20736317 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
rs10993994 in MSMB promoter affects serum MSMB expression, contributes to the genetic predisposition to prostate cancer in southern Chinese Han population.
|
20333697 |
2010 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
After allowing for multiple testing, none of the SNPs examined were significantly associated with growth factor or hormone concentrations, and the SNP-prostate cancer associations did not differ by these concentrations, although 4 interactions were marginally significant (MSMB-rs10993994 with androstenedione (uncorrected P = 0.008); CTBP2-rs4962416 with IGFBP-3 (uncorrected P = 0.003); 11q13.2-rs12418451 with IGF-1 (uncorrected P = 0.006); and 11q13.2-rs10896449 with SHBG (uncorrected P = 0.005)).
|
22459122 |
2012 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results suggest a mechanism by which rs10993994 might predispose to prostate cancer and raise the possibility that genetic variation might need to be considered in interpreting the levels of these biomarkers.
|
20696662 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recent functional work has shown that different alleles of the significantly associated SNP in the promoter of MSMB found to be associated with prostate cancer risk, rs10993994, can influence its expression in tumors and in vitro studies.
|
19644707 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found.
|
30774776 |
2019 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
|
26443449 |
2015 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Regardless of race and ethnicity or rs10993994 genotype, men with low blood levels of MSP have increased risk of prostate cancer.
|
23213189 |
2013 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Two susceptibility loci identified for prostate cancer aggressiveness.
|
25939597 |
2015 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant.
|
19997100 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These data indicate that the increase in PC risk associated with rs10993994:C>T is likely mediated by the variant's effect on PSP94 expression; however, this effect does not extend to NCOA4 in the data presented here.
|
22887727 |
2013 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
|
20676098 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For the two SNPs that had significant differences between more and less aggressive disease rs2735839 in KLK3 (P = 8.4 x 10(-7)) and rs10993994 in MSMB (P = 0.046), the alleles that are associated with increased risk for PCa were more frequent in patients with less aggressive disease.
|
19434657 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our data indicated that MSMB gene rs10993994 polymorphism was associated with an increased risk of PC.
|
28212531 |
2017 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
|
26034056 |
2015 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of prostate cancer in Latinos.
|
31226226 |
2020 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This study demonstrated a significant association between the MSMB rs10993994 polymorphisms and PCa risk.
|
31773691 |
2019 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
PCa susceptibility was associated with TT genotype of SNP rs10993994 in this cohort of Scottish men and the increased risk of PCa was modified by serum enterolactone concentrations.
|
22733159 |
2012 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure.
|
23608167 |
2013 |