rs121913500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion.
|
31846689 |
2020 |
rs12976445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further the heterozygous CT of miR-196a2 (rs11614913) (OR-1.88, CI-1.06 to 3.35, p-0.02) and homozygous CC of miR-125a (rs12976445) (OR-2.55, CI -1.15 to 4.65, p-0.03) showed increased risk for prostate cancer.
|
29594807 |
2020 |
rs13426236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study provides strong evidence showing that prostate cancer risk SNP rs13426236 upregulates expression of MLPH transcript V4, which may function as a candidate oncogene in prostate cancer.
|
31659808 |
2020 |
rs35672330
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two other EXO5 SNPs significantly associated with risk of PCa in cases-controls study from databases of genotype and phenotype (dbGaP), which are in linkage disequilibrium (D' = 1) with Exo5 L151P found in PCa family.
|
31616062 |
2020 |
rs57095329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistical analysis revealed the heterozygous AG genotype of the rs57095329 was significantly decreased in the cases when compared to the controls (OR-0.45, CI -0.24 to 0.85, p value-0.02) indicating an inverse association of this genotype with prostate cancer.
|
29594807 |
2020 |
rs772893086
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion.
|
31846689 |
2020 |
rs919467999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two other EXO5 SNPs significantly associated with risk of PCa in cases-controls study from databases of genotype and phenotype (dbGaP), which are in linkage disequilibrium (D' = 1) with Exo5 L151P found in PCa family.
|
31616062 |
2020 |
rs1046040
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis proposed that rs3787016 T/rs1046040 C significantly increased the risk of PCa compared to C/C (p = 0.037).
|
30587086 |
2019 |
rs1047840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that CDH1 -160C/A and Exo1 K589E polymorphisms are associated with increased susceptibility to prostate cancer in Bangladeshi population.
|
30880589 |
2019 |
rs1076064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population.
|
31423132 |
2019 |
rs1125927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found 12 novel loci for PCa including rs1125927 (TMEM17, P = 3.95 × 10<sup>-16</sup>), rs73862213 (GATA2, P = 5.87 × 10<sup>-23</sup>), rs77911174 (ZMIZ1, P = 5.28 × 10<sup>-20</sup>), and rs138708 (SUN2, P = 1.13 × 10<sup>-15</sup>), seven of which had crucially low minor allele frequency in European population.
|
31562322 |
2019 |
rs1126647
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A T A haplotype (rs4073, rs2227306 and rs112</span>6647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03).
|
30641210 |
2019 |
rs11639084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11639084 and rs4774388 alleles were not different between PCa and normal groups 95% CI: 0.52-1.24, OR = 1.04, P = .34; 95% CI: 0.48-1.33, OR = .79, P = .39 respectively.
|
30251751 |
2019 |
rs1192131078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, the rs61752561 SNP (Asp84Asn substitution) in exon 3 of the kallikrein-related peptidase 3 (<i>KLK3</i>) gene encoding prostate-specific antigen (PSA) was reported to be strongly associated with PCa risk (<i>P</i> = 2.3 × 10<sup>-8</sup>).
|
30538125 |
2019 |
rs12680047
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs9642880, rs16902359, and rs12680047) and 79 SNP-SNP pairs were significantly associated with prostate cancer risk.
|
30914434 |
2019 |
rs1569686
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although there was no consistent evidence of an association between DNMT3B variants and PCa mortality, the TT genotype of rs1569686 was associated with LINE-1 hypomethylation in tumor tissue and DNMT3B mRNA expression was associated with an increased risk of lethal PCa.
|
30341411 |
2019 |
rs16902359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs9642880, rs16902359, and rs12680047) and 79 SNP-SNP pairs were significantly associated with prostate cancer risk.
|
30914434 |
2019 |
rs1799796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was detected between <i>RAD51</i> rs5030789 polymorphism and <i>XRCC3</i> rs1799796 polymorphism and an increased risk of prostate cancer.
|
31186630 |
2019 |
rs1815009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of the present study revealed an association between rs1815009, rs2684788 and PCa risk, which involves altered miRNA regulation and contributes to cancer susceptibility.
|
30365147 |
2019 |
rs2069845
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the frequency of rs</span>2069845 variants was not significantly different between PCa, BPH and control groups.
|
30345492 |
2019 |
rs2227306
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A T A haplotype (rs4073, rs2227306 and rs1126647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03).
|
30641210 |
2019 |
rs2297441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RTEL1</i> rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, <i>P</i> = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk.
|
31762827 |
2019 |
rs2301241
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With respect to acrylamide-gene interactions, only rs1800566 in NAD(P)H quinone dehydrogenase 1 (NQO1) and rs2301241 in thioredoxin (TXN) showed a nominally statistically significant multiplicative interaction with acrylamide intake for advanced prostate cancer risk.
|
29697282 |
2019 |
rs2308327
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the data suggest the rs2308327 and rs2308321 polymorphisms of the MGMT gene were nor associated with the susceptibility of prostate cancer.
|
31190217 |
2019 |
rs25655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using parallel reaction monitoring, the expression of seven mutant peptides was found to be altered in tumors, amongst which CAPN2 D22E was the most significantly up-regulated mutant peptide in PCa tissues.
|
31243108 |
2019 |