|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Six markers associated with early-onset prostate cancer [rs2171492 (7q32), rs6983561 (8q24), rs10993994 (10q11), rs4430796 (17q12), rs1799950 (17q21), and rs266849 (19q13)] were genotyped.
|
22144497 |
2012 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.
|
31562322 |
2019 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
|
24753544 |
2014 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, in a small case-control study of prostate cancer cases from Utah high-risk pedigrees, we have significantly replicated association of prostate cancer with rs10993994</span> (10q11) upon study-wide correction for multiple comparisons.
|
19336566 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs10993994 genotype in the MSMB gene modifies the association between number of sexual partners and PCa risk.
|
24037734 |
2013 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Rs11672691 and rs10993994 were associated with both fatal and nonfatal PCa, while rs6465657, rs7127900, rs2735839, and rs13385191 were associated with nonfatal PCa only.
|
24411283 |
2014 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.
|
20967219 |
2010 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
BACKGROUND.With recent advances in high-throughput sequencing technologies, many prostate cancer risk loci have been identified, including rs10993994, a single nucleotide polymorphism (SNP) located near the MSMB gene.
|
24464504 |
2014 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility.
|
19383797 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The observations that rs10993994 is the strongest associated variant in the region and its risk allele has a major effect on the transcriptional activity of MSMB, a gene with previously described prostate cancer suppressor function, together suggest the T allele of rs10993994 as a potential causal variant at 10q11 that confers increased risk of prostate cancer.
|
19153072 |
2009 |
|
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk.
|
21085629 |
2010 |
|
rs10993994
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association scan for variants associated with early-onset prostate cancer.
|
24740154 |
2014 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We performed a retrospective analysis of germline DNA samples from Ashkenazi Jewish men and a comparison group of non-Ashkenazi men treated for prostate cancer at our institution to determine the prevalence of HOXB13 G84E mutation in prostate cancer patients of Ashkenazi Jewish heritage, an ethnic group common to the New York City area.
|
23475555 |
2013 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results indicated that significant increased PCa susceptibility was associated with rs138213197 compared with non-carriers (OR = 3.38, 95% CI: 2.45-4.66).
|
27626483 |
2016 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
While the HOXB13 G84E mutation may be rare, there may be a future role in genetic testing for this mutation after further studies of clinical utility in assessing prostate cancer risk.
|
24310616 |
2014 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was a stronger association between the G84E variant and PC among men with no first-degree relative with PC (OR, 4.04; 95% CI, 1.12-14.51) compared to men with a family history of PC (OR, 1.49; 95% CI, 0.30-7.50; P = 0.36 for interaction).
|
23129385 |
2013 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
HOXB13 G84E is prevalent in >1% of the Swedish population and is associated with a 3.5-fold increased risk of prostate cancer.
|
22841674 |
2014 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The age-specific risk of prostate cancer among G84E mutation carriers was higher than among non-carriers.
|
25629170 |
2015 |
|
rs138213197
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Testing for the G84E mutation in men with a positive family history may help distinguish those who merit more regular screening for prostate cancer.
|
23396964 |
2013 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The prostate cancer risk allele p.G84E was identified in 18 (0.56%) of 3,187 cases and 16 (0.70%) of 2,300 controls (OR = 0.81, 95% CI = 0.41-1.59, P = 0.54).
|
27424772 |
2016 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
While there was a trend toward an earlier age at diagnosis, overall the clinicopathologic features of PCa were not significantly different in G84E carriers and non-carriers.
|
29181843 |
2018 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The recurrent p.Gly84Glu germline mutation (G84E) in HOXB13 is consistently associated with prostate cancer (PCa), although the mechanisms underlying such linkage remain elusive.
|
30560549 |
2019 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A rare mutation G84E in HOXB13 was recently identified to be associated with prostate cancer (PCa) in Caucasians.
|
22718278 |
2013 |
|
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Interplay of <i>HOXB13</i> (G84E) and <i>CIP2A</i> (R229Q) variants results in highest observed inherited prostate cancer risk (OR, 21.1; <i>P</i> = 0.000024).
|
30181389 |
2018 |