rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The observations that rs10993994 is the strongest associated variant in the region and its risk allele has a major effect on the transcriptional activity of MSMB, a gene with previously described prostate cancer suppressor function, together suggest the T allele of rs10993994 as a potential causal variant at 10q11 that confers increased risk of prostate cancer.
|
19153072 |
2009 |
rs10993994
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk.
|
21085629 |
2010 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We performed a retrospective analysis of germline DNA samples from Ashkenazi Jewish men and a comparison group of non-Ashkenazi men treated for prostate cancer at our institution to determine the prevalence of HOXB13 G84E mutation in prostate cancer patients of Ashkenazi Jewish heritage, an ethnic group common to the New York City area.
|
23475555 |
2013 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results indicated that significant increased PCa susceptibility was associated with rs138213197 compared with non-carriers (OR = 3.38, 95% CI: 2.45-4.66).
|
27626483 |
2016 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
While the HOXB13 G84E mutation may be rare, there may be a future role in genetic testing for this mutation after further studies of clinical utility in assessing prostate cancer risk.
|
24310616 |
2014 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was a stronger association between the G84E variant and PC among men with no first-degree relative with PC (OR, 4.04; 95% CI, 1.12-14.51) compared to men with a family history of PC (OR, 1.49; 95% CI, 0.30-7.50; P = 0.36 for interaction).
|
23129385 |
2013 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
HOXB13 G84E is prevalent in >1% of the Swedish population and is associated with a 3.5-fold increased risk of prostate cancer.
|
22841674 |
2014 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The age-specific risk of prostate cancer among G84E mutation carriers was higher than among non-carriers.
|
25629170 |
2015 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Testing for the G84E mutation in men with a positive family history may help distinguish those who merit more regular screening for prostate cancer.
|
23396964 |
2013 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The prostate cancer risk allele p.G84E was identified in 18 (0.56%) of 3,187 cases and 16 (0.70%) of 2,300 controls (OR = 0.81, 95% CI = 0.41-1.59, P = 0.54).
|
27424772 |
2016 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
While there was a trend toward an earlier age at diagnosis, overall the clinicopathologic features of PCa were not significantly different in G84E carriers and non-carriers.
|
29181843 |
2018 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The recurrent p.Gly84Glu germline mutation (G84E) in HOXB13 is consistently associated with prostate cancer (PCa), although the mechanisms underlying such linkage remain elusive.
|
30560549 |
2019 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A rare mutation G84E in HOXB13 was recently identified to be associated with prostate cancer (PCa) in Caucasians.
|
22718278 |
2013 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Interplay of <i>HOXB13</i> (G84E) and <i>CIP2A</i> (R229Q) variants results in highest observed inherited prostate cancer risk (OR, 21.1; <i>P</i> = 0.000024).
|
30181389 |
2018 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study confirms the association between the HOXB13 G84E variant and prostate cancer and suggests a novel association between G84E and leukemia and a suggestive association with bladder cancer.
|
26108461 |
2015 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The germline mutation G84E of HOXB13 is a rare but recurrent mutation associated with elevated risk of prostate cancer in men of European descent, with an effect size that is greater than observed for previously validated risk variants of genome wide association studies.
|
22714738 |
2012 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Then, 25 studies including 51,390 cases and 93,867 controls were included, and there was significant association between HOXB13 p.Gly84Glu mutation and overall cancer risk (OR = 2.872, 95% CI = 2.121-3.888, P < 0.001), particularly in prostate cancer (OR = 3.248, 95% CI = 2.313-4.560, P < 0.001), while no association was found in breast (OR = 1.424, 95% CI = 0.776-2.613, P = 0.253) and colorectal cancers (OR = 2.070, 95% CI = 0.485-8.841, P = 0.326).
|
26517352 |
2015 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer.
|
24722062 |
2014 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the G84E mutation of HOXB13, a relatively recent mutation that likely occurred in Northern Europe, significantly increases risk for PCa.
|
23393222 |
2013 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This study confirms the overall importance of the HOXB13 G84E mutation in prostate cancer susceptibility.
|
23292082 |
2013 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The G84E mutation predisposes to prostate cancer in Poland, but accounts for only a small proportion of cases.
|
23334858 |
2013 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The absolute PCa risk by age 85 for a male HOXB13 G84E carrier varied from 60% for those with no PCa family history to 98% for those with two relatives diagnosed at young ages, compared with an average risk of 15% for noncarriers.
|
30527799 |
2019 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We identified 101 heterozygous carriers of G84E who underwent radical prostatectomy for prostate cancer between 1985 and 2011 and matched these men by race, age and tumor grade to 99 HOXB13 wild-type controls.
|
28186998 |
2017 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In the present study, carriers of the rare G84E variant in HOXB13 were both younger at the time of diagnosis and more likely to have a family history of prostate cancer compared with homozygotes for the wild-type allele.
|
24148311 |
2014 |
rs138213197
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The HOXB13 G84E variant is associated with risk of prostate cancer (PCa), however the role this variant plays in P</span>Ca development is unknown.
|
29259341 |
2017 |