Gene: MSMB ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant. 19997100

2010
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation GWASCAT Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. 20676098

2010
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. 20967219

2010
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. 21085629

2010
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE In conclusion, loci associated with risk for prostate cancer, such as rs7920517 and rs10993994, might also be used to predict the recurrence of prostate-specific antigen in prostate cancer patients receiving radical prostatectomy. 19900942

2009
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE Recent functional work has shown that different alleles of the significantly associated SNP in the promoter of MSMB found to be associated with prostate cancer risk, rs10993994, can influence its expression in tumors and in vitro studies. 19644707

2009
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE For the two SNPs that had significant differences between more and less aggressive disease rs2735839 in KLK3 (P = 8.4 x 10(-7)) and rs10993994 in MSMB (P = 0.046), the alleles that are associated with increased risk for PCa were more frequent in patients with less aggressive disease. 19434657

2009
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE In conclusion, in a small case-control study of prostate cancer cases from Utah high-risk pedigrees, we have significantly replicated association of prostate cancer with rs10993994</span> (10q11) upon study-wide correction for multiple comparisons. 19336566

2009
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE Further investigation is warranted to determine whether rs10993994 alone or in combination with additional variants contributes to prostate cancer susceptibility. 19383797

2009
dbSNP: rs10993994
rs10993994
MSMB
0.800 GeneticVariation BEFREE The observations that rs10993994 is the strongest associated variant in the region and its risk allele has a major effect on the transcriptional activity of MSMB, a gene with previously described prostate cancer suppressor function, together suggest the T allele of rs10993994 as a potential causal variant at 10q11 that confers increased risk of prostate cancer. 19153072

2009
dbSNP: rs10993994
rs10993994
MSMB
T 0.800 GeneticVariation GWASCAT Multiple loci identified in a genome-wide association study of prostate cancer. 18264096

2008
dbSNP: rs10993994
rs10993994
MSMB
T 0.800 GeneticVariation GWASCAT Multiple newly identified loci associated with prostate cancer susceptibility. 18264097

2008
dbSNP: rs7904463
rs7904463
MSMB ; LOC105378287
0.010 GeneticVariation BEFREE We found nominal evidence (P < 0.05) for association between prostate cancer and three chromosome 8q24 (rs6983561, rs16901979, and rs7000448) and two 10q11 (rs7904463 and rs10740051) SNPs. 20717903

2011