|
rs58262369
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10(-8); PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10(-10); ESR2).
|
26443449 |
2015 |
|
rs58262369
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10(-8); PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10(-10); ESR2).
|
26443449 |
2015 |
|
rs1256049
|
|
|
0.030 |
GeneticVariation |
BEFREE |
When patients were grouped according to smoking status, the ESR2 rs1256049 AA genotype (OR = 0.48, 95 % CI 0.25-0.95, P < 0.05) and ESR2 rs4986938 AG + AA genotype (OR = 0.64, 95 % CI 0.41-1.00, P < 0.05) showed significantly decreased PCa risk in the ever-smoker group.
|
26251204 |
2015 |
|
rs4986938
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ESR2 rs4986938 AG and AG + AA genotypes were associated with significantly decreased risk of PCa (AG: OR = 0.68, 95 % CI 0.47-0.97, P < 0.05 and AG + AA: OR = 0.67, 95 % CI 0.47-0.94, P < 0.05).
|
26251204 |
2015 |
|
rs1256049
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis indicated that ESR1 rs9340799 polymorphism was associated with prostate cancer risk in overall populations, Caucasians and Africans, while ESR2 rs1256049 polymorphism was associated with prostate cancer risk in Caucasians.
|
24859835 |
2014 |
|
rs1256049
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Estrogen receptors alpha (rs2234693 and rs9340799), and beta (rs4986938 and rs1256049) genes polymorphism in prostate cancer: evidence for association with risk and histopathological tumor characteristics in Iranian men.
|
22228197 |
2012 |
|
rs4986938
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Estrogen receptors alpha (rs2234693 and rs9340799), and beta (rs4986938 and rs1256049) genes polymorphism in prostate cancer: evidence for association with risk and histopathological tumor characteristics in Iranian men.
|
22228197 |
2012 |
|
rs4986938
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, an interactive association with BMI was observed in the relationship between prostate cancer risk and genotypes of ESR2 38 bp 3' of STP G>A (rs4986938) (p = 0.031).
|
19654868 |
2009 |
|
rs8018687
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from this study showed that six single base-pair polymorphisms (SNPs) of ESR1 (rs1801132, rs2077647, rs746432, rs2273206, rs851982, rs2228480) and four SNPs of ESR2 (rs4986938, rs928554, rs8018687, rs number not available for ESR2 5696 bp 3' of STP A>G) were not significantly associated with prostate cancer risk, either by allelic or genotypic frequencies.
|
19654868 |
2009 |
|
rs928554
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from this study showed that six single base-pair polymorphisms (SNPs) of ESR1 (rs1801132, rs2077647, rs746432, rs2273206, rs851982, rs2228480) and four SNPs of ESR2 (rs4986938, rs928554, rs8018687, rs number not available for ESR2 5696 bp 3' of STP A>G) were not significantly associated with prostate cancer risk, either by allelic or genotypic frequencies.
|
19654868 |
2009 |