|
rs7975232
|
|
|
0.030 |
GeneticVariation |
BEFREE |
SNP 4 had a significant protective effect (β=-0.6, p<0.05); whereas, SNP 7 (rs7975232) showed an increase association with prostate cancer risk and high Gleason score (β=0.32, p<0.05).
|
31243105 |
2019 |
|
rs731236
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results Our findings suggest a significant association between rs731236 and prostate cancer risk in Asians and African Americans, but rs1544410 was not associated with prostate cancer under three genetic models.
|
28222630 |
2017 |
|
rs731236
|
|
|
0.030 |
GeneticVariation |
BEFREE |
rs731236 and rs7975232 were significantly associated with PCa risk (p<0.05).
|
25750310 |
2015 |
|
rs7975232
|
|
|
0.030 |
GeneticVariation |
BEFREE |
rs731236 and rs7975232 were significantly associated with PCa risk (p<0.05).
|
25750310 |
2015 |
|
rs731236
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We also examined vitamin D related genes, VDR and CYP27B1, and found a significant association of PCa with the TaqI polymorphism (rs731236) in the former.
|
21358824 |
2011 |
|
rs7975232
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our findings suggest that the VDR ApaI (rs7975232) polymorphism may play a role in the development of sporadic PCa.
|
18849534 |
2008 |
|
rs1544410
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between vitamin D receptor gene <i>Bsm I</i> (rs1544410) polymorphism and prostate cancer (PCa) risk has been investigated by numerous previous studies, which yielded inconsistent results.
|
30122987 |
2018 |
|
rs1544410
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results Our findings suggest a significant association between rs731236 and prostate cancer risk in Asians and African Americans, but rs1544410 was not associated with prostate cancer under three genetic models.
|
28222630 |
2017 |
|
rs2239182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The statistical analysis suggested that two VDR sequence variants (rs2408876 and rs2239182) had a significant association with prostate cancer risk (odds ratio [OR].
|
24120391 |
2014 |
|
rs2408876
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The statistical analysis suggested that two VDR sequence variants (rs2408876 and rs2239182) had a significant association with prostate cancer risk (odds ratio [OR].
|
24120391 |
2014 |
|
rs11168314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three VDR tagSNPs (rs3782905, rs7299460, and rs11168314), one CYP27B1 tagSNP (rs3782130), and five CYP24A1 tagSNPs (rs3787557, rs4809960, rs2296241, rs2585428, and rs6022999) significantly altered risks of PCa death.
|
20687218 |
2010 |
|
rs7299460
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three VDR tagSNPs (rs3782905, rs7299460, and rs11168314), one CYP27B1 tagSNP (rs3782130), and five CYP24A1 tagSNPs (rs3787557, rs4809960, rs2296241, rs2585428, and rs6022999) significantly altered risks of PCa death.
|
20687218 |
2010 |
|
rs11574143
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among men in the lowest tertile of serum 25(OH)D (<48.9 nmol/l), however, prostate cancer risk was related to tag SNPS in or near the 3' untranslated region (UTR) of VDR, with the strongest association for rs11574143 [odds ratio (95% confidence interval) for risk allele carriers versus wild-type: 2.49 (1.51-4.11), P = 0.0007]; the genotype associations were null among men in tertile 2 and tertile 3.
|
19255064 |
2009 |
|
rs2107301
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genotype analysis, homozygotes at two VDR loci (rs2107301 and rs2238135) were associated with a 2- to 2.5-fold higher risk of prostate cancer compared with the homozygote common allele [odds ratio, 2.47 (95% confidence interval, 1.52-4.00; P = 0.002) and 1.95 (95% confidence interval, 1.17-3.26; P = 0.007), respectively; P value corrected for multiple comparisons for VDR = 0.002].
|
17932346 |
2007 |
|
rs2238135
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genotype analysis, homozygotes at two VDR loci (rs2107301 and rs2238135) were associated with a 2- to 2.5-fold higher risk of prostate cancer compared with the homozygote common allele [odds ratio, 2.47 (95% confidence interval, 1.52-4.00; P = 0.002) and 1.95 (95% confidence interval, 1.17-3.26; P = 0.007), respectively; P value corrected for multiple comparisons for VDR = 0.002].
|
17932346 |
2007 |