Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.850 | GeneticVariation | BEFREE | The C1858T polymorphism of the PTNP22 gene reduces the expression of its encoded LYP, which increases the risk of GD and HT. | 28133421 | 2017 |
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0.850 | GeneticVariation | BEFREE | (3) regarding the subtypes of AITDs, patients with Graves' disease (GD) had a significant higher degree of C1858T polymorphism (TT vs. CC, OR=2.35, 95%CI=1.36˜4.05; TC vs. CC, OR=1.46, 95%CI=1.12˜1.89; TT/TC vs. CC, OR=1.54, 95%CI=1.33˜1.80; TT vs. TC/CC, OR=2.16, 95%CI=1.25˜3.72), while no association was observed in patients with Hashimoto's thyroiditis (HT).No publication bias was observed. | 22374238 | 2012 |
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A | 0.850 | GeneticVariation | GWASCAT | Seven newly identified loci for autoimmune thyroid disease. | 22922229 | 2012 |
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0.850 | GeneticVariation | GWASDB | Seven newly identified loci for autoimmune thyroid disease. | 22922229 | 2012 |
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0.850 | GeneticVariation | BEFREE | To evaluate the prevalence of PTPN22 C1858T polymorphism in young type 1 diabetes patients with or without autoimmune thyroiditis. | 20438787 | 2010 |
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0.850 | GeneticVariation | BEFREE | Stratifying patients affected with AITDs according to their phenotype (Graves' disease and Hashimoto's thyroiditis) and RA patients according to the presence of rheumatoid factor (RF) and antibodies against cyclic citrullinated peptides (ACPA) did not show any significant association with PTPN22 R620W allele (p>0.05). | 19343596 | 2009 |
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0.850 | GeneticVariation | BEFREE | The minor allele of the R620W missense single-nucleotide polymorphism (SNP; rs2476601) in the PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been reported to be associated with multiple autoimmune diseases, including type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, autoimmune thyroiditis and vitiligo. | 16464986 | 2006 |