|
rs633862
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Supplementary to the previous GWAS, our study provides additional evidence on the prognostic value of the 9q34.2 rs633862 variant in EOC patients, and this variant may function by regulating the <i>ABO</i> mRNA expression.
|
29109911 |
2017 |
|
rs8170
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Common variant rs8170 and rare variants in ATG2B may be associated with EOC overall survival, although further study is needed.
|
26747452 |
2016 |
|
rs8170
|
|
A |
0.720 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs633862
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs633862
|
|
A |
0.720 |
GeneticVariation |
GWASCAT |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs8170
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
|
20852633 |
2010 |
|
rs142091544
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs142091544
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs4286604
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs4286604
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs4525119
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs4525119
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs7643459
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs7643459
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs17329882
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Additionally, haplotype analyses indicated that the haplotype block that contained rs17329882 was significantly associated with epithelial ovarian cancer risk, specifically with the serous epithelial ovarian cancer subtype.
|
28231729 |
2017 |
|
rs11782652
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs1243180
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs17329882
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs757210
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs11175194
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs11175194
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs1192691
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs1192691
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs1413299
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs1413299
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |