rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A recent genome-wide association study identified a novel single nucleotide polymorphism (SNP), rs2046210, in the 6q25 region as a breast cancer susceptibility locus in Chinese and subsequently replicated in a multicenter study.
|
21528353 |
2011 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After adjusting for rs2046210, the association of rs6913578 with breast cancer risk in African Americans approached borderline significance.
|
21303983 |
2011 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Despite some limitations, this meta-analysis demonstrates that the rs2046210 polymorphism may be a risk factor associated with increased breast cancer risk.
|
23609471 |
2013 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3).
|
24510657 |
2015 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Furthermore, C6ORF97 showed significant worse prognostic values especially in luminal B subtype in the publically available data sets. rs2046210 and the upstream gene C6ORF97 might have substantial roles not only in carcinogenesis but also in progression toward a more aggressive phenotype in breast cancer patients, which suggests that functional studies of this locus are imperative.
|
25370037 |
2015 |
rs2046210
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
rs2046210
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
rs2046210
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
23544013 |
2013 |
rs2046210
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
23544013 |
2013 |
rs2046210
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
|
27354352 |
2016 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a genome-wide association study conducted among Chinese women, we identified the single nucleotide polymorphism (SNP) rs2046210 at 6q25.1 for breast cancer risk.
|
26645718 |
2016 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women.
|
24289300 |
2013 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In joint analyses that included both SNPs, the rs2046210-A allele was associated with increased risk of breast cancer [odds ratio (OR) = 1.14; 95% confidence interval (CI) = 1.02-1.28], and the rs2046211-G allele was associated with reduced risk (OR = 0.80; 95% CI = 0.67-0.95).
|
23104177 |
2013 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In summary, our findings suggested that the rs2046210 polymorphism may serve as a potential genetic biomarker of BC in both Asians and Caucasians.
|
30693664 |
2019 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests the participation of rs2046210 at 6q25.1 in the susceptibility for BC, especially in Europeans and Asians.
|
23888322 |
2013 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 × 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 × 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031).
|
21593217 |
2011 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05).
|
22452962 |
2012 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings emphasized the proof of principle that multiple interactions of genetic variants, including rs3757318, rs2046210, and rs4973768 may play important roles in the susceptibility of BC though the biological mechanisms underlying the observed associations need to be elucidated.
|
24265035 |
2013 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results provide strong evidence to support that the common polymorphism near the ESR1 gene, rs2046210, is associated with an increased risk of breast cancer in Asian and European populations but not in Africans, although the biological mechanisms need to be further investigated.
|
23272245 |
2012 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, all of the five SNPs contributed to breast cancer susceptibility in a dominant genetic model (2q35, rs13387042: adjusted OR = 1.26, P = 0.006; 3q24.1, rs2307032: adjusted OR = 1.24, P = 0.005; 6q22.33, rs2180341: adjusted OR = 1.22, P = 0.006; 6q25.1, rs2046210: adjusted OR = 1.51, P = 2.40 × 10-8; 10q26.13, rs2981582: adjusted OR = 1.31, P = 1.96 × 10-4).
|
22269215 |
2012 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs2046210 at 6q25.1, located upstream of the gene encoding estrogen receptor alpha (ESR1), showed strong and consistent association with breast cancer across all three stages.
|
19219042 |
2009 |
rs2046210
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
SNP rs2046210 at 6q25.1, located upstream of the gene encoding estrogen receptor alpha (ESR1), showed strong and consistent association with breast cancer across all three stages.
|
19219042 |
2009 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The genotype of rs2046210 (6q25.1), rs2981582 (EGFR2), rs889312 (MAP3K1), and rs3803662 (TOX3/TNRC9) has no statistical differences in different subtypes of breast cancer.
|
26803517 |
2016 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The other two SNPs (rs2046210 and rs3734805) were strongly associated with susceptibility to breast cancer.
|
27525837 |
2016 |