|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a nested case-control study of 380 women with incident breast cancer and 662 controls within the Singapore Chinese Health Study, we found no association between either green tea intake or gene polymorphisms of MTHFR (C677T and A1298C) and TYMS (1494 ins/del) and breast cancer risk.
|
18669903 |
2008 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
|
16777985 |
2006 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A2756G) and 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) are associated with breast cancer, we performed a multigenic case-control study of the effects to breast cancer risk of four polymorphisms of folate-metabolizing genes against duration of estrogen exposure.
|
17896178 |
2008 |
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rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated independent and joint effects of B vitamin intake as well as two polymorphisms of a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C] on breast cancer risk.
|
15735051 |
2005 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the MTHFR SNPs, C677T and A1298C, were associated with breast cancer survival.
|
17069650 |
2006 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, no significant associations were found between MTHFR A1</span>298C polymorphism and breast cancer risk when all studies pooled into the meta-analysis (AC vs. AA: OR=0.99, 95% CI 0.94-1.05; CC vs. AA: OR 0.99, 95% CI 0.90-1.09; dominant model: OR=0.99, 95% CI 0.95-1.04; and recessive model: OR=0.98, 95% CI 0.90-1.08).
|
21052845 |
2011 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, it has been shown in patients with breast cancer a risk of presenting with an aggressive biophenotype about twice or three times higher in the presence of the C677T and A1298C polymorphisms, respectively.
|
31523170 |
2019 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association between the A1298C polymorphism and the risk to develop breast cancer was determined.
|
30877449 |
2019 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that there is no significant association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility for overall population.
|
27568010 |
2016 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present data suggest that germ-line polymorphisms of C677T, C1298A for MTHFR and R2 for FV are associated in breast cancer and may be additional prognostic markers related to breast cancer survival.
|
23803051 |
2013 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Viable cell growth, MDI, and polymorphism frequency in MTRR (A66G and C524T) and MTHFR (A1298C and A1793G) did not differ among the study groups; however, MDI tended to be higher in BRCA carriers with breast cancer than those without and was significantly increased in MTHFR 677T allele carriers relative to wild-type carriers (P=0.017).
|
18842997 |
2008 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR A1298C genotype was associated with a decreased risk of BC [OR=0.68; 95% CI: 0.49-0.95].
|
24023349 |
2013 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between the combined MTHFR C677T-A1298C polymorphism and breast cancer are possible from this study.
|
22901194 |
2012 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the association of two common MTHFR polymorphisms (C677T and A1298C) and their haplotypes in a candidate-gene association study, involving 300 female patients with BC and 283 healthy women.
|
21875371 |
2012 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Folate intake, vitamin B12 intake and variants of MTHFR C677T and MTHFR A1298C demonstrated no association with risk of breast cancer.
|
24175799 |
2013 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the 1298 A>C polymorphism is not significantly associated with increased risks of breast cancer.
|
24945727 |
2014 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T and A1298C polymorphisms are likely to play an important role in the susceptibility to br</span>east cancer.
|
15004488 |
2004 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of 18 case-control studies investigating the association between the C677T and the A1298C polymorphisms of the MTHFR gene and breast cancer (BC) was carried out.
|
16630166 |
2006 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conducted a hospital-based case-control study to investigate the associations of dietary intake of folate and MTHFR C677T and A1298C polymorphisms with breast cancer in a Chinese population.
|
25078601 |
2014 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk.
|
26662439 |
2015 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The role of folate in BC is equivocal, association studies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial.
|
25318348 |
2015 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the relationship between two common MTHFR polymorphisms (C677T and A1298C) and breast cancer (BC) chemotherapy response.
|
27706773 |
2016 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-UTR, MTR A2756G and cSHMT C1420T and also the folate carrier (RFC1 G80A) and breast cancer risk in a northeastern Brazilian population.
|
22134752 |
2012 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study points out the importance of the interactions between the MTHFR C677T, MTHFR A1298C and MTR A2756G polymorphisms, and also highlights the relevance of the MTR A2756G polymorphism and age in breast cancer risk.
|
23155246 |
2012 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed and their joint effects with individual age- and estrogen-related factors on breast cancer risk were discussed.
|
25075036 |
2014 |