|
rs1001179
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we investigated the effect of MnSOD (p.Val16Ala, rs4880) and CAT (-262C>T, rs1001179) SNPs on the association between the MD and BC risk in the case-control study of BC MASTOS in Cyprus.
|
26130326 |
2016 |
|
rs1001179
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Highly active women harboring variant alleles in CAT rs1001179 were at increased risk of breast cancer compared with women with the common CC genotype (OR = 1.61; 95 % CI, 1.06-2.45).
|
23053794 |
2012 |
|
rs10012
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggests that CYP1B1 Arg48Gly, Ala119Ser and Asn453Ser polymorphisms are not associated with breast cancer risk.
|
20054638 |
2010 |
|
rs10012
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs10012
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To examine the association between six SNPs, CYP1A1(*)2A, CYP1A1(*)2C, CYP1A2(*)1F, CYP1B1 Arg(48)Gly, CYP1B1 Leu(432)Val and CYP3A5*3 and breast cancer risk, therefore, we conducted hospital-based case-control studies in Nagano, Japan and São Paulo, Brazil including 873 pairs (403 Japanese (JJ), 81 Japanese Brazilians (JB) and 389 non-Japanese Brazilians (NJB)).
|
19229255 |
2009 |
|
rs10022462
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs1003623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the rs1003623, the T allele was associated with an increased breast cancer risk among postmenopausal women with odds ratios (ORs) of 1.4 (95% Confidence Intervals (CIs) = 1.0-1.9) for the CT and 1.6 (95% CIs = 1.0-2.4) for the TT, (P for trend = 0.03).
|
17431766 |
2007 |
|
rs10043985
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the AC and AC + CC genotypes of TSLP rs10043985 were confirmed to be associated with an increased risk of BC risk in women aged above 48 years, compared with the AA genotype (AC and AC + CC vs. AA: OR = 9.468, CI = 0.493-181.768, p = 0.04537).
|
31210014 |
2019 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We can conclude that the rs10046 polymorphism on CYP19 by itself does not constitute breast cancer risk.
|
23342035 |
2013 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No rs10046 genotypes were significantly associated with increased breast cancer risk or patient character</span>istics other than age at onset.
|
24402127 |
2014 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a case-control study nested within a breast self-examination trial conducted in China, we examined whether CYP19A1 polymorphisms (rs1870049, rs1004982, rs28566535, rs936306, rs11636639, rs767199, rs4775936, rs11575899, rs10046, and rs4646) were associated with risk of breast cancer and fibrocystic breast conditions.
|
19064562 |
2008 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
SNPs rs10046 and rs4646 may influence the HER2 status of breast cancer tumors, and rs10046 genotypes are associated with an altered DFS.
|
18049890 |
2008 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common haplotype composed of the Val(80) G allele and three haplotype-tagging single nucleotide polymorphisms (rs727479, rs10046, and rs4646) in the CYP19 coding region showed a trend to association with breast cancer risk in BRCA1 carriers ages <50 years.
|
19366906 |
2009 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association was observed between the rs10046 polymorphism of the CYP19gene and breast cancer in Iranian patients.
|
27165202 |
2016 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, breast cancer in Xinjiang Uigur women is closely connected with the age, BMI, parity, abortion, and CYP19 rs10046 polymorphisms.
|
26345775 |
2015 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study provides evidence that polymorphisms CYP17 rs743572, CYP19 rs10046 and ER-alpha rs3798577 are associated with breast cancer risk among Chinese women.
|
18629629 |
2009 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also found no evidence for a significant association of rs10046 genotypes with breast cancer prognosis.
|
29363090 |
2018 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygotes of minor alleles of CYP19 rs10046 (CC) were associated with a reduced risk of BC with OR: 0.61 (95%CI = 0.39-0.95).
|
27323034 |
2016 |
|
rs10046
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer.
|
23935996 |
2013 |
|
rs1004982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of breast cancer with (but not without) proliferative fibrocystic conditions was increased among women homozygous for the minor allele of rs1004982 (C), rs28566535 (C), rs936306 (T), and rs4775936 (C) relative to those homozygous for the major allele [age-adjusted odds ratios (95% confidence intervals), 2.19 (1.24-3.85), 2.20 (1.27-3.82), 1.94 (1.13-3.30), and 1.95 (1.07-3.58), respectively].
|
19064562 |
2008 |
|
rs10053538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical analysis showed that the expression of TIM-3 protein in the breast cancer tissues was higher in patients carrying the rs10053538 GT+TT genotype than those with GG genotype (P = 0.012).
|
27248321 |
2016 |
|
rs10057194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from the current meta-analysis suggest that the rs2075685 (G>T) and rs6869366 (G>T) polymorphisms of the XRCC4 gene might increase the risk of breast cancer, whereas rs2075685 (G>T) and rs10057194 (A>G) might be protective factors.
|
22994773 |
2012 |
|
rs10069690
|
|
T |
0.750 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs10069690
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The variants rs10069690 and rs2853676 were also described as risk factors for BC.
|
29332343 |
2019 |
|
rs10069690
|
|
T |
0.750 |
GeneticVariation |
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |