Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104895033
rs104895033
NBN
0.010 GeneticVariation BEFREE The initial two stages, which involved up to 797 high-risk BC patients, 1504 consecutive BC cases, and 1081 healthy women, indicated a potentially BC-predisposing role for 6 candidates, i.e., USP39 c.*208G > C, PZP p.Arg680Ter, LEPREL1 p.Pro636Ser, SLIT3 p.Arg154Cys, CREB3 p.Lys157Glu, and ING1 p.Pro319Leu. 31754952

2020

dbSNP: rs1333049
rs1333049
0.010 GeneticVariation BEFREE In the current study, we studied the association of a genetic variant in CDKN2A/B, rs1333049, with the risk of developing breast cancer. 31721206

2020

dbSNP: rs1334767632
rs1334767632
0.010 GeneticVariation BEFREE The initial two stages, which involved up to 797 high-risk BC patients, 1504 consecutive BC cases, and 1081 healthy women, indicated a potentially BC-predisposing role for 6 candidates, i.e., USP39 c.*208G > C, PZP p.Arg680Ter, LEPREL1 p.Pro636Ser, SLIT3 p.Arg154Cys, CREB3 p.Lys157Glu, and ING1 p.Pro319Leu. 31754952

2020

dbSNP: rs140897205
rs140897205
0.010 GeneticVariation BEFREE The initial two stages, which involved up to 797 high-risk BC patients, 1504 consecutive BC cases, and 1081 healthy women, indicated a potentially BC-predisposing role for 6 candidates, i.e., USP39 c.*208G > C, PZP p.Arg680Ter, LEPREL1 p.Pro636Ser, SLIT3 p.Arg154Cys, CREB3 p.Lys157Glu, and ING1 p.Pro319Leu. 31754952

2020

dbSNP: rs1429142
rs1429142
0.010 GeneticVariation BEFREE We previously identified a novel breast cancer susceptibility variant on chromosome 4q31.22 locus (r</span>s1429142) conferring risk among women of European ancestry. 31087647

2020

dbSNP: rs145240281
rs145240281
0.010 GeneticVariation BEFREE The initial two stages, which involved up to 797 high-risk BC patients, 1504 consecutive BC cases, and 1081 healthy women, indicated a potentially BC-predisposing role for 6 candidates, i.e., USP39 c.*208G > C, PZP p.Arg680Ter, LEPREL1 p.Pro636Ser, SLIT3 p.Arg154Cys, CREB3 p.Lys157Glu, and ING1 p.Pro319Leu. 31754952

2020

dbSNP: rs1485746664
rs1485746664
0.010 GeneticVariation BEFREE The initial two stages, which involved up to 797 high-risk BC patients, 1504 consecutive BC cases, and 1081 healthy women, indicated a potentially BC-predisposing role for 6 candidates, i.e., USP39 c.*208G > C, PZP p.Arg680Ter, LEPREL1 p.Pro636Ser, SLIT3 p.Arg154Cys, CREB3 p.Lys157Glu, and ING1 p.Pro319Leu. 31754952

2020

dbSNP: rs2585428
rs2585428
0.010 GeneticVariation BEFREE The results showed that rs2585428 was associated with cancer risk in Caucasian population, rs4809960 was associated with breast cancer risk in Caucasian population, and rs6022999 was associated with cancer risk in Asian population. 31740231

2020

dbSNP: rs28897743
rs28897743
0.010 GeneticVariation BEFREE We have successfully identified a novel, germline heterozygous, missense mutation of the gene BRCA2: c.7007G>T, p.R2336L, which is likely to be pathogenic in the proband and her elder sister who both had breast cancer. 31782247

2020

dbSNP: rs3740753
rs3740753
0.010 GeneticVariation BEFREE Patients carrying rs1042838 G/T, rs590688 C/C, and rs10895068 G/A genotypes had higher risk of breast cancer, while carriage of rs3740753 G/G genotype was associated with marginal reduction in breast cancer risk. 29302853

2020

dbSNP: rs376066276
rs376066276
0.010 GeneticVariation BEFREE R64Q, a breast cancer-associated TRIM21 mutation, abolishes the interaction between TRIM21 and Snail, and the TRIM21-mediated ubiquitination and degradation of Snail. 31622717

2020

dbSNP: rs6022999
rs6022999
0.010 GeneticVariation BEFREE The results showed that rs2585428 was associated with cancer risk in Caucasian population, rs4809960 was associated with breast cancer risk in Caucasian population, and rs6022999 was associated with cancer risk in Asian population. 31740231

2020

dbSNP: rs63749795
rs63749795
0.010 GeneticVariation BEFREE Genotyping illustrated that MLH1 polymorphisms (rs63749795 and rs63749820) were significantly associated (P ≤ 0.05) with risk of developing BC. 31701475

2020

dbSNP: rs63749820
rs63749820
0.010 GeneticVariation BEFREE Genotyping illustrated that MLH1 polymorphisms (rs63749795 and rs63749820) were significantly associated (P ≤ 0.05) with risk of developing BC. 31701475

2020

dbSNP: rs751877902
rs751877902
0.010 GeneticVariation BEFREE The initial two stages, which involved up to 797 high-risk BC patients, 1504 consecutive BC cases, and 1081 healthy women, indicated a potentially BC-predisposing role for 6 candidates, i.e., USP39 c.*208G > C, PZP p.Arg680Ter, LEPREL1 p.Pro636Ser, SLIT3 p.Arg154Cys, CREB3 p.Lys157Glu, and ING1 p.Pro319Leu. 31754952

2020

dbSNP: rs766794072
rs766794072
0.010 GeneticVariation BEFREE The initial two stages, which involved up to 797 high-risk BC patients, 1504 consecutive BC cases, and 1081 healthy women, indicated a potentially BC-predisposing role for 6 candidates, i.e., USP39 c.*208G > C, PZP p.Arg680Ter, LEPREL1 p.Pro636Ser, SLIT3 p.Arg154Cys, CREB3 p.Lys157Glu, and ING1 p.Pro319Leu. 31754952

2020

dbSNP: rs912505
rs912505
0.010 GeneticVariation BEFREE We studied the relationships between CYP24A1 gene SNPs (rs2209314, rs2585428, rs2762941, rs3787555, rs4809959, rs73913757, rs912505, and rs927a650), adult weight change and BC risk. 31696340

2020

dbSNP: rs10043985
rs10043985
0.010 GeneticVariation BEFREE In addition, the AC and AC + CC genotypes of TSLP rs10043985 were confirmed to be associated with an increased risk of BC risk in women aged above 48 years, compared with the AA genotype (AC and AC + CC vs. AA: OR = 9.468, CI = 0.493-181.768, p = 0.04537). 31210014

2019

dbSNP: rs1017105
rs1017105
0.010 GeneticVariation BEFREE For rs1017105, which is located in the 3'-UTR of CLDN12, significant differences were observed in the recessive model between the pCR and non-pCR patients with luminal-type BC. 31157259

2019

dbSNP: rs1059122
rs1059122
0.010 GeneticVariation BEFREE Our results suggested that rs1059122 (FAM13A), rs17748 (PHLDB1), and rs4809957 (CYP24A1) might contribute to breast cancer susceptibility in the Chinese Han population. 31215377

2019

dbSNP: rs1063320
rs1063320
0.010 GeneticVariation BEFREE The main objective of the study is to evaluate the impact of three <i>HLA-G</i> 3'UTR potential polymorphisms: +3187 A > G (rs9380142), +3142 G > C (rs1063320), +2960 14-base pair (bp) Insertion/Deletion (Ins/Del) (rs66554220), and the HLA-E*01:01/01:03 A > G (rs1264457) polymorphism in Tunisian breast cancer population. 30945586

2019

dbSNP: rs10838524
rs10838524
0.010 GeneticVariation BEFREE The study showed a relationship between an increased BC risk under the dominant genetic model of <i>CRY2</i> rs10838524, <i>PER2</i> rs934945, and recessive genetic model of <i>PER1</i> rs2735611. 31739444

2019

dbSNP: rs10841753
rs10841753
0.010 GeneticVariation BEFREE <b>Patients & methods:</b> Postmenopausal women with hormone-receptor positive breast cancer were genotyped for <i>SLCO1B1*5</i> (rs4149056) and rs10841753. 31190621

2019

dbSNP: rs10877887
rs10877887
0.010 GeneticVariation BEFREE We examined two SNPs rs10877887 and rs13293512 in the promoters of let-7 family to determine if the two SNPs were related to the occurrence of breast cancer (BC). 31028134

2019

dbSNP: rs1111875
rs1111875
0.010 GeneticVariation BEFREE Six SNPs were associated with all-cause (CDKAL1-rs981042, P = 0.0032; HHEX-rs1111875, P = 0.0361; and INSR-rs919275, P = 0.0488) or BC-specific (CDKN2A/CDKN2B-rs3218020, P = 0.0225; CDKAL1-rs981042, P = 0.0246; and TCF2/HNF1B-rs3094508, P = 0.0344) mortality in additive genotype models, at α = 0.05. 30457165

2019