Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1136410
rs1136410
0.060 GeneticVariation BEFREE Using data/samples collected from the first 752 Caucasians and 141 African-Americans in an ongoing case-control study, we examined the association between breast cancer risk and 18 non-synonymous single-nucleotide polymorphisms (nsSNPs) in four DNA repair pathways-(i) base excision repair: ADPRT V762A, APE1 D148E, XRCC1 R194W/R280H/R399Q and POLD1 R119H; (ii) nucleotide excision repair: ERCC2 D312N/K751Q, ERCC4 R415Q, ERCC5 D1104H and XPC A499V/K939Q; (iii) mismatch repair: MLH1 I219V, MSH3 R940Q/T1036A and MSH6 G39E and (iv) double-strand break repair: NBS1 E185Q and XRCC3 T241M. 18701435

2008

dbSNP: rs1136410
rs1136410
0.060 GeneticVariation BEFREE This meta-analysis indicates that ADPRT Val762Ala and APE1 Asp148Glu polymorphisms are not associated with increased breast cancer risk. 23272074

2012

dbSNP: rs1136410
rs1136410
0.060 GeneticVariation BEFREE We aimed to explore the modification effects of PARP1 rs1136410 and ESR1 rs2234693 on the association between passive smoking and breast cancer risk among pre- and post-menopausal women. 23644255

2013

dbSNP: rs1136410
rs1136410
0.060 GeneticVariation BEFREE Taken together, this the first study that confirmed Val762Ala variant has functional effect and structural impact on the PARP1 and may play an important role in breast cancer progression in Saudi population. 24392019

2013

dbSNP: rs1136410
rs1136410
0.060 GeneticVariation BEFREE There was no evidence to suggest that rs25489, rs1799782, rs1130409, rs1805414 and rs1136410 were associated with breast cancer risk. 29662639

2018

dbSNP: rs1136410
rs1136410
0.060 GeneticVariation BEFREE No association was detected between rs1136410 and susceptibility to BC among studied groups. 31288058

2019