Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The results indicated that, for Latinos, the C677T polymorphism is associated with a significant risk for developing breast cancer, whereas the A1289C polymorphism does not. 30877449

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Furthermore, it has been shown in patients with breast cancer a risk of presenting with an aggressive biophenotype about twice or three times higher in the presence of the C677T and A1298C polymorphisms, respectively. 31523170

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE However, a meta-analysis of the 6 association studies carried out in Turkish populations with 707 patients and 880 controls showed a significant association between breast cancer and the MTHFR gene C677T polymorphism. 27614738

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our results indicated that MTHFR C677T is significantly associated with thyroid and breast cancer risks. 27173331

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The MTHFR C677T genotype may be associated with BC chemotherapy response, and could be of great value in guiding individualized treatment for this disease. 27706773

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The study aimed at evaluating the influence of MTHFR 677C>T and NQO1 609C>T polymorphisms in toxicity and response to chemotherapy in breast cancer patients. 26014925

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The role of folate in BC is equivocal, association studies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial. 25318348

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The association between methylenetetrahydrofolate reductase 677C>T polymorphisms and breast cancer susceptibility: A meta-analysis based on Chinese Han population. 26323926

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE 677 C>T substitution does not affect breast cancer risk in the Indo-European and Dravidian populations of India. 25803740

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE These results suggest that the 677TT genotype of the C677T polymorphism in the MTHFR gene is associated with BC susceptibility in the Mexican population. 25966173

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population. 26081619

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This article suggests that methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism was significantly associated with breast cancer risk in Chinese population.The result is encouraging. 26537580

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Genetic polymorphism of MTHFR C677T may modulate the risk of breast cancer especially in the 41-60 year age group. 26163632

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In addition, individuals with the TT genotype of MTHFR 677C/T were associated with increased risk of breast cancer by logistic regression analysis; the adjusted odds ratio (95%CI) was 3.05 (1.17-8.87). 26662439

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In summary, during this meta-analysis, we found that MTHFR C677T polymorphism was significantly associated with breast cancer risk in the Chinese population. 24078451

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The results of this meta-analysis suggest that 677 C>T polymorphism in the MTHFR gene may contribute to breast cancer development. 24945727

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This case-control study found that the MTHFR C677T and MTR A2756G polymorphisms are associated with risk of breast cancer, and folate, vitamin B6, and vitamin B12 intakes influence these associations. 25217320

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The findings suggest that the MTHFR C677T polymorphism but not A1298C, and some variants on their combined genotypes or haplotypes may be involved with the development of breast cancer. 24973876

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In addition, females carrying MTHFR C</span>677T CT or TT genotypes had a higher odds ratio of 1.21 (95% confidence interval=1.03-1.42, p=1.85E-5) for breast cancer, especially before the age of 45.4 years (odds ratio=1.51 and 95% confidence interval=1.20-1.90). 25075036

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The present meta-analysis strongly suggested a significant association between the MTHFR C677T polymorphism and risk of breast cancer in Asian populations. 25081713

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In conclusion, our study demonstrated that MTHFR C677T polymorphism and folate are associated with risk of breast cancer. 25078601

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Folate intake, vitamin B12 intake and variants of MTHFR C677T and MTHFR A1298C demonstrated no association with risk of breast cancer. 24175799

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The present data suggest that germ-line polymorphisms of C677T, C1298A for MTHFR and R2 for FV are associated in breast cancer and may be additional prognostic markers related to breast cancer survival. 23803051

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We examined the association of two common MTHFR polymorphisms (C677T and A1298C) and their haplotypes in a candidate-gene association study, involving 300 female patients with BC and 283 healthy women. 21875371

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Associations between the combined MTHFR C677T-A1298C polymorphism and breast cancer are possible from this study. 22901194

2012