rs1137101
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Moreover, there were significant association between the Gln223Arg genotype and breast cancer risk; homozygotes for AA and heterozygotes for AG,AG + GG genotypes had been proved to increase the risk of b</span>reast cancer, and their corresponding odds ratio were 7.14 (95% confidence interval [CI] = 1.92-25.64), 1.33(95% CI = 1.03-2.70), and 2.04 (95% CI = 1.09-3.82).
|
18668212 |
2008 |
rs1137101
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We utilized a polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) assay to evaluate the association between the Gln223Arg polymorphism of the leptin receptor gene and breast risk in Nigeria in a case control study involving 209 women with breast cancer and 209 controls without the disease.
|
19017403 |
2008 |
rs1137101
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Overall, the results showed null significant association between LEP G2548A, LEPR Q223R, LEPR Lys109Arg, or PON1 Q192R polymorphism and breast cancer risk; however, PON1 L55M was significantly associated with breast cancer risk overall (MM vs. LL: OR = 2.16; 95% CI, 1.76-2.66).
|
21887553 |
2011 |
rs1137101
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This meta-analysis enrolled eight studies to estimate the overall risk of LEPR Gln223Arg polymorphism associated with breast cancer.
|
21698367 |
2012 |
rs1137101
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This pooled analysis suggested that rs1137101 and rs1137100 polymorphisms were significantly correlated with breast cancer risk and the A allele of LEPR rs1137101 variant and the G allele of LEPR rs1137100 variant were low-penetrant risk factors for developing breast cancer.
|
22983835 |
2012 |
rs1137101
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In the stratified analysis, there was no significant association of LEPR Q223R variant with breast cancer, colorectal cancer and non-Hodgkin's lymphoma (NHL) under any models.
|
25261679 |
2014 |
rs1137101
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This article suggests that the A allele of LEPR gene rs1137101 variant was low-penetrant risk factor for developing breast cancer.The result is encouraging.
|
25863476 |
2015 |
rs1137101
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In conclusion, LEP G2548A polymorphism has no relationship with BC susceptibility, while LEPR Q223R polymorphism could decrease BC risk in Asians, but not in overall individuals and Caucasians.
|
28938640 |
2017 |