|
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In Asian populations, there were significant associations of rs3803662</span> and rs8051542 with breast cancer risk.
|
26239137 |
2015 |
|
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, we show that there is little overlap between the breast cancer risk single nucleotide polymorphisms (SNPs) identified so far and the SNPs associated with breast cancer prognosis, with the possible exceptions of LSP1-rs3817198 and TNRC9-rs3803662.
|
25611573 |
2015 |
|
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results indicated that both polymorphisms were significantly associated with the risk of breast cancer, with per allele OR = 1.35, (95%CI = 1.17-1.57) for rs2046210 and per allele OR = 1.24 (95%CI = 1.06-1.45) for rs4784227.
|
25531440 |
2014 |
|
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results indicate an additive effect of the TOX3 rs3803662 and 2q35 rs13387042 alleles for BC risk.
|
24532140 |
2014 |
|
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We conclude that SNP rs3803662 is a putative risk factor for breast cancer in Chinese Han women.
|
24446301 |
2014 |
|
rs17879961
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In total, 26,336 cases and 44,219 controls from 18 case-control studies were used in this meta-analysis, and significant associations of the CHEK2 I157T variant with cancer susceptibility were found (OR, 1.39; 95% CI, 1.19-1.63; p<0.0001), breast cancer (OR=1.58, 95% CI=1.42-1.75, p<0.00001) and colorectal cancer (OR=1.67, 95% CI=1.24-2.26, p=0.0008).
|
23713947 |
2013 |
|
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Despite some limitations, this meta-analysis demonstrates that the rs2046210 polymorphism may be a risk factor associated with increased breast cancer risk.
|
23609471 |
2013 |
|
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests the participation of rs2046210 at 6q25.1 in the susceptibility for BC, especially in Europeans and Asians.
|
23888322 |
2013 |
|
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In joint analyses that included both SNPs, the rs2046210-A allele was associated with increased risk of breast cancer [odds ratio (OR) = 1.14; 95% confidence interval (CI) = 1.02-1.28], and the rs2046211-G allele was associated with reduced risk (OR = 0.80; 95% CI = 0.67-0.95).
|
23104177 |
2013 |
|
rs2046210
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The present meta-analysis demonstrated that the rs2046210 polymorphism may be associated with increased BC susceptibility, but this association varies in different ethnicities.
|
23785413 |
2013 |
|
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women.
|
24289300 |
2013 |
|
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings emphasized the proof of principle that multiple interactions of genetic variants, including rs3757318, rs2046210, and rs4973768 may play important roles in the susceptibility of BC though the biological mechanisms underlying the observed associations need to be elucidated.
|
24265035 |
2013 |
|
rs2046210
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
23544013 |
2013 |
|
rs2046210
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
23544013 |
2013 |
|
rs3803662
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer.
|
24069142 |
2013 |
|
rs3803662
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
rs3803662
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk.
|
23544012 |
2013 |
|
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer.
|
23893088 |
2013 |
|
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Ten of the 11 breast cancer susceptibility loci reported by consortia also showed associations in our predominantly Caucasian study population, and the associations were independent of BMI; four FGFR2 SNPs and TNRC9-rs3803662 were among the most notable associations.
|
23717390 |
2013 |
|
rs3803662
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of breast cancer in the Japanese population.
|
24143190 |
2013 |
|
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Three SNPs were significantly associated with a breast cancer risk in multivariate analysis: rs2046210 (per allele OR=1.37 [95% CI: 1.11-1.70]), rs3757318 (OR=1.33[1.05-1.69]), and rs3803662 (OR=1.28 [1.07-1.55]).
|
24289300 |
2013 |
|
rs17879961
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our research indicates that the CHEK2 I157T variant may be another important genetic mutation which increases risk of breast cancer, especially the lobular type.
|
22799331 |
2012 |
|
rs17879961
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Comparing the prevalence of CHEK2 mutations in BC with controls revealed that carriers of an I157T variant had OR of 1.80 for luminal A subtype and carriers of truncating mutations had OR of 6.26 for luminal B subtype of BC.
|
21701879 |
2012 |