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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-UTR, MTR A2756G and cSHMT C1420T and also the folate carrier (RFC1 G80A) and breast cancer risk in a northeastern Brazilian population.
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22134752 |
2012 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
This study points out the importance of the interactions between the MTHFR C677T, MTHFR A1298C and MTR A2756G polymorphisms, and also highlights the relevance of the MTR A2756G polymorphism and age in breast cancer risk.
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23155246 |
2012 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
The aim of the present study was to search for an association of the protease activated receptor (PAR)1 gene -506 insertion/deletion (I/D), factor V Leiden (FVL), prothrombin (PT) G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms with disease-free survival (DFS) in breast cancer.
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21822552 |
2012 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Low dietary folate intake (P < 0.001), RFC1 G80A (OR: 1.38, 95% CI 1.06-1.81) and MTHFR C677T (OR: 1.74 (1.11-2.73) were independently associated with the breast cancer risk whereas cSHMT C1420T conferred protection (OR: 0.72, 95% CI 0.55-0.94).
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21161404 |
2011 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We investigated the independent and the combined effects of two commonly occurring polymorphisms, MTHFR 677C>T (rs1801133) and MTHFR 1298A>C (rs1801131), as well as their interaction with the use of hormone replacement therapy (HRT), to determine their potential contribution to breast cancer risk.
|
21461582 |
2011 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Increased breast cancer risk has been observed with both low folate status and a functional polymorphism in methylenetetrahydrofolate reductase (MTHFR 677C --> T).
|
19707223 |
2010 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
It can be concluded that potentially functional MTHFR C677T polymorphism may play a low penetrance role in the development of breast cancer.
|
20135343 |
2010 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Although the authors first determined whether genotypes of drug-metabolizing enzymes and transporters--glutathione S-transferase (GST) genes, GSTM1 positive/null, GSTT1 positive/null and GSTP1 A313G, methylenetetrahydrofolate reductase (MTHFR) C677T, reduced folate carrier 1 (RFC1) G80A, and breast cancer resistant protein (BCRP) C421A--were associated with hepatotoxicity for 24 patients, no significant difference was detected for genotype and allelic frequencies between the patients with and those without severe treatment-related hepatotoxicity.
|
20670164 |
2010 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Crude ORs with 95% CIs were used to assess the strength of association between the MTHFR C677T polymorphism and breast cancer risk.
|
20143151 |
2010 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Results of this study suggest that theMTHFR C677T polymorphism may modify the association between dietary intake and breast cancer risk.
|
20417243 |
2010 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study.
|
20030812 |
2009 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
However, among postmenopausal women, there was an increase in breast cancer risk for women who were homozygote TT for MTHFR C677T and had high lifetime alcohol intake (>or=1,161.84 oz; OR, 1.92; 95% CI, 1.13-3.28) and for those who had a high number of drinks per drinking day (>1.91 drinks/day; OR, 1.80; 95% CI, 1.03-3.28) compared with nondrinkers who were homozygote CC.
|
19706843 |
2009 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Our data demonstrate for the first time a functional consequence of changes in intracellular folate cofactors resulting from the MTHFR 677T mutation in cells derived from the target organs of interest, thus providing a plausible cellular mechanism that may partly explain the site-specific modification of colon and breast cancer risks associated with the MTHFR C677T mutation.
|
19123462 |
2009 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We investigated the association of TSER, MTHFR C677T, p53 codon 72 and MDR1 C3435T gene polymorphisms with breast carcinoma in women from Canary Islands (Spain).
|
19885596 |
2009 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs1801131) SNPs and if the polymorphisms per se were associated with breast cancer.
|
19336565 |
2009 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
The presence of MTR A2756G mutant allele and MTHFR C677T mutant allele in carriers was associated with increased breast cancer risk [odds ration, 3.2 (P=0.16; 95% confidence interval, 0.76-13.9) and 3.9 (P=0.09; 95% confidence interval, 0.93-16.3), respectively].
|
18842997 |
2008 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Encouraged by recent studies on the MTHFR 677C>T polymorphism and breast cancer risk that suggested an association of the 677 TT genotype with increased breast cancer susceptibility in premenopausal women, we performed an analysis of the relationship between breast cancer risk and the MTHFR 677C>T polymorphism in 210 premenopausal breast cancer patients and sex- and agematched healthy control subjects.
|
17453338 |
2008 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
In a nested case-control study of 380 women with incident breast cancer and 662 controls within the Singapore Chinese Health Study, we found no association between either green tea intake or gene polymorphisms of MTHFR (C677T and A1298C) and TYMS (1494 ins/del) and breast cancer risk.
|
18669903 |
2008 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A2756G) and 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) are associated with breast cancer, we performed a multigenic case-control study of the effects to breast cancer risk of four polymorphisms of folate-metabolizing genes against duration of estrogen exposure.
|
17896178 |
2008 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Our data fail to support a relationship between MTHFR C677T and the risk for breast cancer.
|
16134079 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
A reduced activity of methylenetetrahydrofolate reductase (MTHFR) due to frequent C677T polymorphism affects DNA synthesis, repair and methylation and may be implicated in breast cancer risk.
|
17260091 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing.
|
17180579 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
We found that the MTHFR SNPs, C677T and A1298C, were associated with breast cancer survival.
|
17069650 |
2006 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
|
16777985 |
2006 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Seventeen studies were included in the meta-analysis of MTHFR C677T genotype and breast cancer risk.
|
17105984 |
2006 |