|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer.
|
31467295 |
2019 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data showed a protective effect for CC genotype of rs1045485 variant and C-C haplotype of rs10931936-rs104548 in CASP8 in association with the decrease risk of breast cancer whereas rs10931936 showed no significant association.
|
31362911 |
2019 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.
|
27507139 |
2016 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CASP8 D302H was found to be only associated with breast cancer risk.
|
25553350 |
2014 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CASP8 D302H was associated with reduced breast cancer risk (for H carriers: pooled OR = 0.874, 95% CI: 0.834-0.917).
|
19629679 |
2010 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the CASP8 D302H positive females showed a 50% probability of being free of BC by the age of 78 versus the 2% of the CASP8 negative ones.
|
19214744 |
2010 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The minor allele of CASP8 D302H was significantly associated with a reduced risk of breast cancer (per-allele HR, 0.85; 95% CI, 0.76-0.97; P(trend) = 0.011) and ovarian cancer (per-allele HR, 0.69; 95% CI, 0.53-0.89; P(trend) = 0.004) for BRCA1 but not for BRCA2 mutation carriers.
|
20978178 |
2010 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent work in breast carcinoma has implicated the histidine variant of CASP8 D302H (rs1045485) as a protective risk allele.
|
20033885 |
2010 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer.
|
18823701 |
2009 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both approaches showed statistically significant decreased breast cancer risks for CASP8 D302H.
|
19367188 |
2009 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One such variant in the caspase-8 (CASP8) gene, D302H (rs1045485), has been confirmed to be associated with breast cancer risk, although the functional effect of this polymorphism (if any) is not yet clear.
|
19318553 |
2009 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in CASP8 at 2q33.1 have been associated with the risk of developing cancer, specifically, the D302H variant (rs1045485) with breast cancer in the European population and the -652 6N ins/del promoter variant (rs3834129) with multiple tumours including colorectal cancer (CRC) in the Chinese population.
|
18362937 |
2008 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.
|
17293864 |
2007 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In multivariate analyses, we observed a significantly decreased risk of breast cancer associated with the homozygous minor allele of CASP8 D302H [rs1045485, odds ratio (OR), 0.3; 95% confidence interval (95% CI), 0.1-0.8].
|
17932347 |
2007 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As CASP10 and CASP8 functionally co-operate during apoptosis, we analysed the mutual effect of both CASP10 V410I and CASP8 D302H, resulting in a significant association between the number of the variant alleles I410 and H302 and a highly decreased familial BC risk (OR = 0.35, P(trend) = 0.007), pointing to the interaction between the CASP10 and CASP8 polymorphisms in breast carcinogenesis.
|
16251207 |
2006 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For five SNPs--CASP8 D302H, IGFBP3 -202 c>a, PGR V660L, SOD2 V16A, and TGFB1 L10P--the associations with breast cancer were of borderline statistical significance (P = .016, .060, .047, .056, and .0088 respectively).
|
17018785 |
2006 |
|
rs1045485
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The reproducible, dose-dependent association of CASP8 D302H with breast cancer indicates the potential importance of inherited variation in the apoptosis pathway in breast cancer susceptibility.
|
15601643 |
2004 |