|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the results for 57 SNPs and 2 gene deletions, rs1056827 in CYP1B1, rs2959008 and rs7173655 in CYP11A1, the GSTT1 gene deletion, and rs1052133 in hOGG1 showed a statistically significant interaction with acrylamide intake for ER+ breast cancer risk.
|
29445914 |
2019 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast to the CC and CG genotypes, the GG genotype of rs1052133 located on theOGG1 gene appeared to be a protective factor against developing breast cancer in both Mongoloid and Caucasoid populations.
|
29662639 |
2018 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggested that the carrier of Ser326Cys polymorphism of hOGG1, Cys/Cys vs Ser/Ser, are at higher risk for breast cancer, independent of other hormonal and environmental risk factors.
|
28608470 |
2018 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk.
|
29720094 |
2018 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The hOGG1 SNP rs1052133 (Ser326Cys) minor allele T showed a significant association with breast cancer samples (OR = 1.78, χ2 = 7.86, p = 0.02024).
|
27822728 |
2017 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Similarly ~14-fold increased risk was associated with Val159Gly (p < 0.01), ~17-fold with Gly221Arg (p < 0.005), and ~18-fold with Ser326Cys (p < 0.004) in breast cancer patients compared with controls, whereas analysis of nonsense mutation showed that ~13-fold (p < 0.01) increased breast cancer risk was associated with Trp375STOP in patients compared to controls.
|
26089588 |
2015 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) of OGG1 (Ser326Cys), XRCC1 (Arg399Gln), and APE1 (Asp148Glu and -141T/G) were genotyped and analyzed for their association with breast cancer risk using multivariate logistic regression models.
|
24606430 |
2014 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that the OGG1 Ser326Cys polymorphism may be a risk factor for breast cancer in Asians and postmenopausal patients.
|
24893568 |
2014 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The APEX1 Asp148Glu carrier, in combination with OGG1 rs2072668 and OGG1 Ser326Cys, was strongly associated with an increased risk of BC.
|
24076439 |
2013 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the c.977C>G polymorphism in hOGG1 is associated with an increased risk of breast cancer in Chinese Han women who are younger than 55 years, premenopausal, triple-negative, or p53-positive subgroups.
|
23369609 |
2013 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A population-based cohort study of 470 women diagnosed with primary breast cancer and a median follow up of 52.44 months was conducted to examine the disease-free and overall survival in rs3736729, rs207454 and rs1052133 genetic variants.
|
23443115 |
2012 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotyping of polymorphisms of XRCC1 (Arg194Trp and Arg399Gln), OGG1 (Ser326Cys and Arg229Gln), ERCC2 Lys751Gln, ERCC4 Ser662Pro, and ERCC5 His1104Asp was performed and used to evaluate breast cancer susceptibility.
|
20183911 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis.
|
20058067 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, no significant associations between the hOGG1 Ser32</span>6Cys polymorphism and breast cancer risk were found for Cys/Cys versus Ser/Ser (OR = 1.07, 95% CI: 0.94-1.20), Ser/Cys versus Ser/Ser (OR = 0.99, 95% CI: 0.91-1.07), Cys/Cys + Ser/Cys versus Ser/Ser (OR = 1.00, 95% CI = 0.93-1.08), and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.07, 95% CI: 0.97-1.18).
|
20054639 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed a strong association between breast cancer occurrence and the genotypes C/C of the RAD51-135G/C polymorphism, Ser/Ser of the OGG1-Ser326Cys and Lys/Gln of the XPD-Lys751Gln, whereas the genotypes G/C of the RAD51-135G/C and Lys/Lys of the XPD-Lys751Gln exerted a protective effect against breast cancer.
|
18977234 |
2008 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between having at least one variant allele and breast cancer risk was stronger among moderate alcohol drinkers for Ser(326)Cys [odds ratio (OR), 1.82; 95% confidence interval (95% CI), 1.06-3.10] relative to nondrinkers with the wild-type genotype and among those with higher BMI for 7143A/G (OR, 1.47; 95% CI, 1.10-1.96) and for 11657A/G (OR, 1.41; 95% CI, 1.05-1.88), relative to women with BMI < 25 kg/m(2) and the wild-type genotype.
|
16614128 |
2006 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our novel findings therefore suggest that hOGG1 Ser326Cys polymorphism is unlikely to play a modifying role in individual susceptibility to breast cancer among Asian women.
|
12779082 |
2003 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nonetheless, published data were consistent with associations between: (a) the OGG1 S326C variant and increased risk of various types of cancer; (b) the XRCC1 R194W variant and reduced risk of various types of cancer; and (c) the BRCA2 N372H variant and increased risk of breast cancer.
|
12496039 |
2002 |