|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no association between rs4680 and rs1056836 genotypes and adduct ratios or breast cancer status.
|
30525503 |
2019 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CYP1B1 polymorphism Val432Leu was not associated with breast cancer in Egypt, but may provide clues for future studies into early detection of the disease.
|
27356703 |
2016 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Neither CYP1B1 Leu432Val polymorphisms nor adipose tissue PCBs were independently associated with breast cancer risk.
|
23869875 |
2014 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms CYP1A1 rs1048943, CYP1B1 rs1056836, COMT rs4680, GSTP1 rs1695, GSTT1 null and GSTM1 null which are involved in estrogen metabolism pathway.
|
23000097 |
2013 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, no significant associations between CYP1B1 Val432Leu polymorphism and b</span>reast cancer susceptibility were found for Val/Val versus Leu/Leu (OR = 0.98; 95% CI: 0.90-1.06), Val/Leu versus Leu/Leu (OR = 1.01; 95% CI: 0.93-1.09), Val/Val + Val/Leu versus Leu/Leu (OR = 1.00; 95% CI: 0.93-1.08) and Val/Val versus Val/Leu + Leu/Leu (OR = 0.96; 95% CI: 0.91-1.01).
|
20033481 |
2010 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Apart from the extensively studied Val432Leu polymorphism, three single nucleotide polymorphisms in CYP1B1 have been studied concerning their potential implication in terms of breast cancer risk: Arg48Gly, Ala119Ser and Asn453Ser.
|
20054638 |
2010 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast cancer risks when analyzed individually, COMT wild type (Val(158)Val) in combination with CYP1B1 heterozygous variant (Leu(432)Val) [OR: 0.21; 95% CI (0.05-0.82), p value; 0.021] and COMT heterozygous variant (Val(158)Met) in combination with CYP1B1 wild type (Leu(432)Leu) [OR: 0.29; 95% CI (0.08-0.96), p value; 0.042] showed significant protective association with premenopausal breast cancer risk.
|
20037207 |
2009 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assuming a recessive model, the minor allele of CYP1B1 V432L significantly increased the dose-response relationship between personal diagnostic X-ray exposure and breast cancer risk, adjusted for cumulative occupational radiation dose (p (interaction) = 0.03) and had a similar joint effect for cumulative occupational radiation dose adjusted for personal diagnostic X-ray exposure (p (interaction) = 0.06).
|
19214745 |
2009 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although we found no significant association in the three populations combined, subgroup analyses revealed statistically significant associations of CYP1A2*1F in NJB, and CYP1B1 Leu(432)Val and CYP3A5*3 in JJ with breast cancer risk.
|
19229255 |
2009 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Marsh and colleagues analyzed the CYP1B1*3 (Val432Leu) polymorphism in patients with high-risk stage III and IV breast cancer, who received dose-intense paclitaxel in combination with doxorubicin and cyclophosphamide.
|
18597657 |
2008 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association between the CYP1B1 Val432Leu polymorphism and breast cancer was observed in Asians (for Val/Val and Val/Leu combined, odds ratio (OR) = 1.0, 95% confidence interval (CI): 0.8, 1.2).
|
17053044 |
2007 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the associations between two CYP1A1 polymorphisms (Ile462Val and Thr461Asn) and one CYP1B1 polymorphism (Leu432Val) and breast cancer risk.
|
17063266 |
2007 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (SNPs) in CYP1B1 (Ex2 + 143 C > G, Ex2 + 356 G > T, Ex3 + 251 G > C, Ex3 + 315 A > G) cause amino acid changes (R48G, A119S, L432V and N453S, respectively) and are associated with increased formation of catechol estrogens; however, epidemiologic evidence only weakly supports an association between these variants and breast cancer risk.
|
16847423 |
2006 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the associations between breast cancer and sequence variants in several genes in the estradiol/estrone metabolism pathway (CYP1A1*2A, CYP1A2*1F, CYP1B1 Leu432Val, CYP3A4*1B, COMT Val158Met, SULT1A1Arg213His) as well as the Arg554Lys variant in AHR (a transcription factor for CYP1A1, CYP1A2, and CYP1B1) in a case-control study of 1,339 breast cancer cases and 1,370 controls nested in the Multiethnic Cohort Study.
|
16103451 |
2005 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data shows no association between breast cancer and the Leu432Val polymorphism of the CYP1B1 gene or the tetranucleotide repeats of the CYP19 gene.
|
15072827 |
2004 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a case-only study on 282 women with breast cancer, we studied the interaction effects (ORi) between smoking habits and the gene polymorphisms of Cytochrome P450 1B1 (Val432Leu CYP1B1), Phenol-sulfotransferase 1A1 (Arg213His SULT1A1) and Catechol-O-methyltransferase (Val158Met COMT).
|
14520706 |
2003 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.
|
12618873 |
2003 |
|
rs1056836
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We sought to determine whether two common functional polymorphisms in Cytochrome P450 1B1, V432L (m1), and A453S (m2) are related to breast cancer risk.
|
12010864 |
2002 |