Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE The SNPs of FGFR2 rs1219648 and PI3KCA rs6443624 may contribute to the identification of breast cancer patients at risk of more aggressive disease and may be potential prognostic factors in breast cancer in a Chinese population. 29872343

2018

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE This meta-analysis of case-control studies provides strong evidence that fibroblast growth factor 2 (FGFR2; rs11200014, rs2981579, and rs1219648) polymorphisms are significantly associated with the BC risk. 29390357

2017

dbSNP: rs1219648
rs1219648
G 0.800 GeneticVariation GWASCAT Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. 27354352

2016

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women. 27572905

2016

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3). 24510657

2015

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE In a group of 31 cases diagnosed with breast cancer and 30 healthy women with matched ages, the single-nucleotide polymorphisms (SNPs) rs1219648, rs2981582 in FGFR2 gene were identified by sequence analysis and the SNPs rs10754339, rs10801935, and rs3738414 in the B7-H4 gene were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. 24125968

2014

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Our results indicated a statistically significant association (p<0.05) between rs1219648, but not rs1042522, and risk of breast cancer. 25292094

2014

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC. 23184080

2013

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE In the haplotype analysis, the FGFR2 rs2981582 T / rs2420946 T / rs1219648 G haplotype (ht2) was associated with a significantly increased BC risk compared with the rs2981582 C / rs2420946 C / rs1219648 A haplotype in familial BC and in non-familial early-onset BC (OR = 1.32, 95 % CI 1.06-1.65, P = 0.012; OR = 1.46, 95 % CI 1.11-1.91, P = 0.004, respectively). 23225170

2013

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE There was stronger evidence of an interaction between ever use of estrogen-only HT and increasing number of rs1219648 risk alleles to increase breast cancer risk (interaction P = 0.08). 23435034

2013

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2). 23593120

2013

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE To examine whether these variants contribute to risk of radiation-associated breast cancer in HL, we analyzed 2 independent case-control series, from the United Kingdom and The Netherlands, totaling 693 HL patients, 232 with breast cancer and 461 without. rs1219648, which annotates the FGFR2 gene, was associated with risk in both series (combined per-allele odds ratio = 1.59, 95% confidence interval: 1.26-2.02; P = .000111). 22144180

2012

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Only 5 out of 9 GWAS breast cancer loci were found to be significantly associated with breast cancer in Tunisians: The rs1219648 (G vs. A allele: OR = 1.36, P = 1 × 10(-3)) and rs2981582 (A vs. G allele: OR = 1.55, P = 3 × 10(-6)) of FGFR2 gene; the rs8051542 of the TNRC9 gene (T vs. C allele: OR = 1.40, P = 4 × 10(-4)); the rs889312 of the MAP3K1 gene (C vs. A allele: OR = 1.33, P = 3 × 10(-3)) and the rs13281615 located on 8q24 (G vs. A allele: OR = 1.21, P = 0.03). 22910930

2012

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Four SNPs mapped to 10q26.13/FGFR2 were associated with increased breast cancer risk via an additive model with per-allelic risks (95 % CI) of 1.26 (1.12-1.43) at rs1219648, 1.22 (1.07-1.38) at rs2981582, 1.21 (1.07-1.36) at rs2981579, and 1.18 (1.04-1.35) at rs11200014. 22965832

2012

dbSNP: rs1219648
rs1219648
G 0.800 GeneticVariation GWASCAT A combined analysis of genome-wide association studies in breast cancer. 20872241

2011

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation GWASCAT Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. 21263130

2011

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE In this study, we evaluated the association of the SNP rs1982073 (Leu10Pro) in transforming growth factor-beta 1 (TGFB1) gene and the SNP rs1219648 in fibroblast growth factor receptor 2 (FGFR2) gene with the risk and aggressiveness of breast cancer among women of Han nationality in North China. 20640597

2011

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE The FGFR2-breast cancer association was modified by smoking status, with increased risk for former and current smokers compared to never smokers; former/current smokers carrying two copies of the rs1219648 minor allele were at highest risk with a crude OR (95% confidence interval) of 2.11 (1.52-2.92) compared to never smokers with no rs1219648 variant alleles. 20853316

2011

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case-control studies. 20300826

2010

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that rs2981582, rs1219648, and rs2420946 polymorphisms in FGFR2 are associated with elevated BC risk. 20364400

2010

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE FGFR2 rs1219648 and rs2981582 genotypes were significantly associated with breast cancer in EA only in estrogen receptor-positive (ER+), progesterone receptor-positive (PR+) and HER2/Neu-negative (HER2-) tumors. 19028704

2009

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Two single-nucleotide polymorphisms, rs13387042 (2q35) and rs1219648 (FGFR2 gene), were found to be associated with breast cancer risk. 19789366

2009

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE We genotyped 13 single nucleotide polymorphisms (SNPs) densely covering a 27 kb region within intron 2 of FGFR2 including two SNPs (rs2981582 and rs1219648) significantly associated with breast cancer and a total 40 tagSNPs across 150 kb of the FGFR2 gene. 18285324

2008

dbSNP: rs1219648
rs1219648
0.800 GeneticVariation BEFREE Genetic variation in FGFR2, identified by rs1219648, may account for a substantial fraction of breast cancer in Arab (12%), Ashkenazi (15%), and Sephardi Jewish (22%) populations. 18483326

2008

dbSNP: rs1219648
rs1219648
G 0.800 GeneticVariation GWASCAT A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. 17529973

2007