|
rs1799945
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition, in the stratified analysis by cancer type, an increased risk was identified in hepatocellular carcinoma and breast cancer in C282Y polymorphism, as well as pancreatic cancer in H63D polymorphism, whereas a decreased risk of colorectal cancer was identified in C282Y polymorphism.
|
26107216 |
2015 |
|
rs1799945
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A number of previous studies have demonstrated that the HFE H63D polymorphism is associated with increased risk of incidence multiple types of cancer, including colorectal cancer, breast cancer, liver cancer, pancreatic cancer, and gynecological malignant tumors.
|
26535689 |
2015 |
|
rs1799945
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, we did not find any association between HFE H63D polymorphism and br</span>east cancer risk under all genetic models.
|
23681799 |
2013 |
|
rs1799945
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These changes may explain why C282Y-HFE is a risk factor for colon and breast cancer and possibly protective against Alzheimer's disease while H63D-HFE is a risk factor for neurodegenerative diseases.
|
21243428 |
2011 |
|
rs1799945
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our data suggests that the polymorphisms G388A, C677T, and H63D are not useful in breast cancer diagnosis, but they may be significant additional prognostic markers related to breast cancer survival.
|
21625954 |
2011 |
|
rs1799945
|
|
|
0.080 |
GeneticVariation |
BEFREE |
C282Y/H63D compound heterozygotes were not at increased risk for colorectal cancer (HR = 1.27; 95% CI = 0.80, 2.01), breast cancer (HR = 1.16; 95% CI = 0.74, 1.84), or prostate cancer (HR = 1.08; 95% CI = 0.68, 1.70).
|
20099304 |
2010 |
|
rs1799945
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The latter value was statistically significant (95% CI, 1.4-14.1), indicating that women bearing the H63D mutation may be at an increased breast cancer risk at an age above 57 years.
|
16216474 |
2006 |
|
rs1799945
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our results suggest that HFE H63D mutation frequencies were increased in the b</span>reast cancer patients in comparison to those in the general population.
|
16503999 |
2006 |